The Truth About Genes and Weight Loss in Men

Genes Weight Loss 1

When it comes to genes and weight loss, how much do your genes matter?

It’s a question you may ask, particularly if you’ve been struggling to lose weight.

Could your genes be working against you? And if so, what can you do about it?

What Do Genes Have to Do with Weight Loss in Men?

Just like your genes affect your eye color, hair color, height, and more, they also have a part to play in your weight and body shape.

How much impact genes have on weight depends on the individual. Harvard Health reported in 2019 that for some people, “genes account for just 25 percent of their predisposition to be overweight, while for others the genetic influence is as high as 70 percent to 80 percent.”

How can you tell which side of the spectrum you may be on? Genetic testing may help, which we’ll talk about, but there are certainly some characteristics you can look for.

People likely to be greatly influenced by genes:

  •       Struggle with weight their entire lives, even in childhood.
  •       Have close family members who are overweight or obese.
  •       Have difficulty losing weight even when sticking to a low-calorie diet with exercise for months.

People likely to be less influenced by genes:

  •       Are moderately overweight, but can lose weight when they try (with diet and exercise).
  •       Struggle to avoid eating too much of the foods they enjoy.
  •       Experience ups and downs in weight, particularly around the holiday season or after changing eating patterns.

Regardless of which group you may fall into, your weight is at least somewhat influenced by your genes. But what does that mean, exactly?

Genes Weight Loss 2

What We Know So Far About Genes and Weight Loss

So far, scientists have identified about 400 different genes that seem to be involved in overweight or obesity. These genes interact in complex ways with other genes and with neurotransmitters, hormones, and more to affect the following:

Hunger

How “accurate” is your hunger instinct? Does it signal you when you’re really hungry, or does it spur you to eat for other reasons?

Normally, your hunger response kicks in only when you need to refuel. But if you have certain gene variants, you may be more likely to experience hunger for other reasons, such as when you’re stressed out or bored.

Satiety

Can you sense when you’re full? Certain genes can tell you when you’re full, while others may not signal your brain, potentially making you overeat.

Metabolism

How efficiently does your body burn calories? Your genes can determine that. Some gene variations drive normal metabolism, whereas others may indicate less efficient metabolism.

Sweets and Snacking

How does your brain respond when you eat something sweet? Can you stop eating those brownies after consuming one? Or are you compelled to eat more?

Some genes signal an “average” response to sweet tastes, while others may encourage greater consumption. Your drive to snack, as well, is somewhat affected by your genetics.

Insulin Resistance

Insulin is the hormone that drives glucose from your bloodstream into your cells. If you have insulin resistance, it means your cells don’t respond to insulin very efficiently.

If you have genes that predispose you to insulin resistance, you may be more likely to have higher blood sugar levels, which can ultimately lead to obesity and diabetes.

Carbohydrates

You’ve heard about how some carbohydrates (simple carbs) can lead to weight gain because they break down quickly in the body and spike blood sugar levels. Others are more complex, take longer to break down, and don’t affect weight the same way.

While it’s a good idea for everyone to avoid eating too many simple carbs, your genetics can influence how well you may respond to them.

Some genetic variations, for instance, may help you lose belly fat when you make a point to avoid simple carbs and consume more complex carbs. Others, however, will inspire your body to manage both well, so you won’t notice as much difference.

Fiber

You know that fiber is good for you. It helps keep your digestion going smoothly, and can help reduce your risk of heart disease.

But how much will consuming a high-fiber diet help in your weight loss efforts? Your genes can tell you.

Some are linked with greater improvements than others, meaning that if you have certain genes, you’ll notice better results on a high-fiber diet than others without those genes.

Saturated Fat

Scientists used to believe that the low-fat diet was the best option for most people. Recent research, however, challenged that idea. A 2015 review, for instance, found that reducing saturated fat had no effect on heart attacks, strokes, or all-cause deaths.

Now, scientists are taking a second look at fats. While we know that unsaturated fats (like those in nuts and seeds) are good for you, we’re still not sure about saturated fats (like those in meat and dairy foods).

It turns out that your genetics have a lot to say about it. Depending on which genetic variations you have, you may be more or less affected by the saturated fats you eat. Some genes signal a high tolerance for saturated fats, whereas others markedly increase your risk for early cardiovascular disease or Alzheimers Disease with saturated fat intake.  Knowing where you are on the spectrum can help you determine what sort of diet may help you lose weight.

Protein

We all need protein in our diets, but depending on your genes, you may be able to lose weight more efficiently with a low or high protein intake.

If you’re considering a high-protein diet, for instance, your genetics might help you determine whether it would work for you. Some genes may show, for instance, that a lower intake of protein would be more effective, or that you should make a point to increase your protein intake.

Some Important Details on Genes and Weight Loss

While there are many genes associated with weight loss, a few have been identified as critical in recent years.

Your question might be: Do I have these genes?

FTO

One of them is called the “fat mass and obesity-associated (FTO)” gene. In 2007, researchers reviewed many studies on genes and obesity and identified this as one that could increase your risk of being obese.

Another study that same year found similar results, with the two together showing that those carrying the FTO gene had a 20-30 percent higher risk of being obese than those who did not.

And in a third study, researchers examined obese men and found that the FTO gene was strongly associated with a higher BMI, higher fat body mass index, increased abdominal fatness, increased insulin sensitivity, and decreased HDL “good” cholesterol.

MC4R

Another gene variant identified as increasing the risk of obesity is called the melanocortin-4 receptor gene (MC4R). When scientists examined genetic data from nearly 17,000 people, they found that after FTO, MC4R mutations were the leading cause of severe childhood-onset obesity. It also influenced fat mass, weight, and obesity risk.

Other research shows that MC4R is related to insulin resistance, food intake, and energy balance, and that the gene is significantly associated with higher intakes of total energy and fat.

PLIN-1

Perilipin 1 (PLIN-1) is another gene to be aware of when it comes to weight loss. This is a protein involved in fat storage and the breakdown of fats. It plays a large role in energy and glucose (blood sugar) metabolism, and over the past decade, has been repeatedly associated with body weight and obesity-related complications.

When studying children between the ages of 10 and 18, scientists found that certain PLIN variants (including PLIN-1) were significantly higher in obese participants compared to the control group. They concluded that PLIN may influence the risk of obesity in adolescence.

In another interesting study, scientists reviewed data from about 1,200 overweight and obese people who ate lunch at different times of the day. They found that those with the AA genotype at the PLIN-1 variant struggled more to lose weight when eating late than those who didn’t have this gene variant.

If you have this gene, in other words, you may want to be sure to eat on time!

APOE

The apolipoprotein E (APOE) gene seems to affect metabolism, to the point that it could increase your risk of being overweight.

APOE4, for instance, is associated with a greater risk of metabolic syndrome—a group of symptoms that increase the risk of cardiovascular disease:

  •       hypertension (high blood pressure)
  •       raised blood sugar levels
  •       high triglycerides
  •       reduced HDL “good” cholesterol
  •       a large waistline

In one animal study, researchers fed subjects a high-fat diet for 12 weeks. They found that those subjects with APOE4 were more susceptible to metabolic changes from the diet, including weight gain and high blood sugar levels, than those who did not have the APOE4 genetic variant.

Some other genes that seem to be associated with weight include:

  •   Panx-1: Pannexin-1 helps regulate the accumulation of fat. In a 2018 study, researchers found that when they deleted this gene, subjects gained more weight, and also had a higher risk of obesity later in life.
  •   IRX3: The Iroquois homeobox gene 3 can make it harder to lose weight. This may be because FTO exerts its effects on body weight by changing the expression of IRX3.
  •   Ankyrin-B: If you have this gene, your fat cells may absorb glucose at a faster rate than normal, which increases the size of the fat cell and can cause obesity.

Can You Use Genes and Weight Loss in a Personalized Plan?

The exciting part of all this research is that we’re starting to use what we know to help men more efficiently lose weight.

Wouldn’t it be helpful, for instance, to know whether a high-protein diet would be effective for you? Or how you respond to sweets? Or whether your hunger pangs are accurate or not?

Personalized weight loss plans based on genetics are the future of health, available today. Genetic tests allow you to learn more about what genes you may or may not have that are influencing your ability to lose weight.

The tests are simple—most consist of an easy cheek swab. They provide complex but applicable data on a large number of genetic variants. A genetic coach can review the results with you and help you understand how to apply them.

Genes Weight Loss Scale

Other Things to Consider In Addition to Genes and Weight Loss

It’s important to remember that genes aren’t everything when it comes to weight loss. In fact, depending on your individual makeup, your genes may have only a small effect on your ability to lose weight. This is where epigenetics comes into play – your lifestyle and environment that affect genetic expression.

Your lifestyle, exercise habits, diet, stress levels, and more all play a large role in your body composition. In one study of over 17,000 people, scientists found that those who carried the FTO gene and were active had BMIs that were no higher or lower than those without the FTO gene.

In another study of 240,000 people, those who carried the FTO gene had a 23 percent higher risk of obesity than those who didn’t, but being physically active lowered the risk. Those with the gene who exercised regularly had a 30 percent lower risk of obesity than the inactive FTO-carriers.

At the Gapin Institute, we pride ourselves on working with each individual to determine the best weight loss plan for them. While genetic testing can give us some important data to work with, we also emphasize the power of epigenetics and how your lifestyle and behavior can have a massive impact on your success. We also incorporate a total body composition scan and comprehensive health assessment, among other approaches, to help men succeed in their weight loss goals.

If you’re curious about how you may develop a personalized weight loss plan, schedule a free consultation with a men’s health advisor today.

10 Tips for Men Who Want to Lose Weight After 40

Featured Weight Loss After 40

Lose Weight After 40

If you’ve tried to lose weight after 40, you know the truth—it’s not as easy as it used to be.

Before, you could add a mile to your morning run, pump up your lifting for a few days, or cut back on dessert a night or two and your weight would come back in line.

No more. Once you reach middle age and beyond, weight loss gets a lot harder. What used to work doesn’t work anymore.

Why is that? And what can you do about it?

Why Is It Harder to Lose Weight After 40?

Hormonal Changes

Starting around the age of 40, testosterone levels tend to drop. Testosterone is responsible for regulating fat distribution, muscle strength and mass. As levels go down, the body tends to store more fat.

Men also produce less growth hormone as they age, and growth hormone also helps the body burn fat. According to one 2014 study, the production of growth hormone declines by 14 percent per decade.

Muscle Loss Makes It Harder to Lose Weight After 40

Studies indicate that after the age of 40, people typically lose about 8 percent or more of their muscle mass each decade. The process also accelerates the older you get unless you are fighting back with increased resistance training. If you’re dealing with a chronic disease like diabetes or cardiovascular disease, your rate of muscle loss could be faster.

Since muscle burns more calories than fat, the more muscle you lose, the fewer calories you will burn, sending more to be stored as fat.

Increased Stress

At midlife, we often experience more stress than we did when we were younger. You may be experiencing more work-related stress, and stress is known to contribute to weight gain. If you add on family-related stress, particularly if you have aging parents, the effects could be greater.

Changing Lifestyle

As you enter your 40s and beyond, your career is often in full swing, which can present a few challenges when it comes to weight. You may be extremely busy with work and unable to devote enough time to exercise and eating well. You may also be more sedentary than you were in your younger years, particularly if you work at an office and commute every day.

If you have young children you’re taking care of, or even teenagers that are demanding your attention, you may have little time to yourself, which can lead to dietary changes and skipped days at the gym. And though you are working hard throughout the day, you’re not working out like you may have done when you were in your 20s.

You’re Still Focusing on Aerobic Exercise

What you did in your 20s to lose weight likely won’t work after 40. That’s mainly because sticking to aerobic exercise is no longer enough. Whereas you may have been able to do a daily run or bike ride before to lose weight, doing them now may not have the same effect.

Aerobic exercise is excellent for your cardiovascular health, but it does little to build up your lean muscle mass. You need to add more strength training as well.

Your Old Dietary Changes Don’t Help You Lose Weight After 40

You cut back on calories. You limited your portion sizes. And the weight isn’t going anywhere.

That’s because after the age of 40, simply cutting back on calories is no longer enough. It becomes more about what kinds of foods you’re eating. Those that spike blood sugar levels, for instance, will contribute to weight gain after 40 even if you consume less of them.

Simply cutting calories can also slow down your metabolism as it tries to conserve energy, keeping your weight stubbornly where it is.

You’re Not Getting Enough Sleep

When you’re sleep-deprived, your body releases stress hormones that stimulate hunger—particularly for high-fat and high-sugar foods. That means if you’re regularly getting six hours or less, your body will be primed to gain, not lose, weight.

Your Gut Microbiome is Unbalanced

We all have a balance of good and bad bacteria in the gut. As long as the good guys outnumber the bad, we tend to be healthy overall. But if the bad guys start gaining a foothold, they can cause problems, including those that lead to weight gain.

Researchers found this to be true in a recent study. They analyzed stool samples taken 6-12 months after people started a commercial weight-loss coaching program. The results showed that the gut microbiome could influence the ability to lose weight.

Lose Weight Busy Lifestyle

Does a Slow Metabolism Hinder Weight Loss After 40?

It’s long been an accepted theory that as we age, our metabolism slows down, making it harder to lose weight.

A recent study seemed to negate this idea, at least somewhat.

An international team of scientists analyzed the average calories burned by more than 6,600 people as they went about their lives. The participants’ ages ranged from one week old to 95 years, and they lived in 29 different countries.

The results showed that our metabolisms don’t really start to decline until after the age of 60. Then, a person’s cells do start to slow down. By the age of 90, the scientists estimated that people would need about 26 percent fewer calories each day than someone in midlife.

The scientists concluded that midlife weight gain may have more to do with age-related changes in lifestyle and body composition than it does metabolism.

10 Tips to Help You Lose Weight After 40

It’s more challenging to lose weight after the age of 40. But that doesn’t mean you can’t do it. You simply need to change your approach. We have ten tips to help you do that.

1. One-size-fits-all does NOT work.

One of the biggest mistakes I see men making is following the crowd. If the trend is the keto diet, they try that. If it’s running marathons, they get into that.

Sometimes these approaches work, but often they don’t, and that can leave you feeling discouraged.

The problem is that what works for one person may not work for another. You need to find out what’s making it hard for you to lose weight before you can create a weight-loss plan that will be successful for you.

Your metabolism, hormone balance, microbiome, genetic makeup, and micronutrient status all affect whether or not you can lose weight.

I recommend that men talk to their doctors and get tested to find out what may be going on. In my office, we create personalized weight loss plans that circumvent the frustration and get right to the source of the problem. These may include medical interventions and prescriptions, peptide and supplement management, lifestyle changes, nutrition, and support from certified health coaches.

Once you find out what your body is doing, you can address any problem areas and increase your odds of being able to shed the pounds.

2. Balance your hormones.

As noted above, hormonal changes that you experience as you age can make it harder for you to lose weight.

Balancing your testosterone levels may help. In a 2014 study, researchers found that long-term testosterone therapy in men who tested low for testosterone produced “significant and sustained weight loss, marked reduction in waist circumference and BMI, and improvement in body composition.”

In a later review, researchers found the same results: men with low testosterone who were obese experienced better results when they included testosterone therapy.

How can you tell if you’re low on testosterone? Get tested! According to a 2006 study, 38.7 percent of men tested were deficient in testosterone. The odds were higher in men with high blood pressure, high blood sugar, diabetes, and obesity than men without these conditions.

Obesity and low testosterone levels are also interrelated, according to the research, and “strongly influenced by dietary factors.” More about that below!

Remember that testosterone isn’t the only hormone you want to check. Growth hormone is the other important one. We can treat that with diet and supplements, which can help you lose weight.

In one study of obese adults, researchers found that those treated with growth hormone had a 1.6-fold increase in body weight loss as fat and a greater loss of visceral fat than those who received a placebo.

Weight Loss Diet

3. Determine your best weight-loss diet.

Simply picking a diet out of the air is unlikely to lead you to successful weight loss. You may think that you can increase your exercise and make it work, but that usually fails too.

Instead, after you find out what’s going on in your body, you can formulate a diet that will work for you. If you’re low on testosterone, for instance, cutting back on desserts and pastries may be particularly important.

In a 2018 study, those who had a pattern of eating more bread and pastries, dairy products, desserts, and restaurant foods were more likely to have low testosterone levels. These men also had a pattern of consuming too few homemade foods and dark green vegetables.

In general, the following tips are critical when you’re trying to lose weight after 40:

  • Return to real foods—fruits, vegetables, whole grains, lean proteins, and nuts and seeds.
  • Limit or avoid refined sugars—it promotes weight gain as well as diabetes and heart disease.
  • Cut back on all processed foods—anything that comes in a bag or box and is likely high in sugar, fat, and sodium.
  • Make plant-based proteins a cornerstone of your diet. When choosing animal-based proteins, focus on lean meats and fish.
  • Limit dairy intake. When you do consume it, choose organic and grass-fed.

Beyond these basics, I also recommend bumping up your protein intake. Studies show it helps encourage weight loss, plus it will support your efforts to build more muscle. In a 2017 study, researchers found that those on a high protein diet lost significantly more weight than those in a standard protein diet.

4. Consider fasting to lose weight after 40.

There are a variety of different ways to try fasting. What they all have in common is that they allow your body to go for extended periods without food. This is helpful for a few reasons.

First, fasting forces your body’s cells to resort to other ways to produce energy. That means they are more likely to use fat for energy rather than glucose, which can help you lose weight.

Second, fasting helps bring your attention more fully to what you usually eat. It reminds you that you don’t need to be consistently consuming, and can help you to approach your diet more mindfully.

Finally, fasting can be just what your body needs to jumpstart your weight loss. It pulls it out of its habitual way of burning calories and forces it to regroup.

Most of us fast when we sleep. You can easily extend that time by choosing to stop eating after 8:00 at night and not to eat again until 8:00 the next morning. That simple 12-hour fast can help increase bodily repair and make it easier for you to lose weight.

In a recent review of 27 trials, researchers found that intermittent fasting resulted in weight loss of 0.8 percent to 13 percent with no serious adverse events.

Stress Management

5. Develop stress-management tools.

You may not realize it, but stress could be a tall barrier between you and your efforts to lose weight.

Particularly if your stress is ongoing—or chronic—it could be having a large effect on your ability to reach your health goals.

In a 2017 study comparing stress levels and body weight, researchers found that levels of the stress hormone cortisol in the participants’ hair were significantly correlated to larger waist circumference and higher body mass index (BMI).

In a later study, researchers again found that higher cortisol levels and chronic stress were predictive of greater future weight gain.

The problem is that cortisol is a strong appetite stimulant, meaning that you will be more inclined to eat when you’re stressed out. You know how it goes—you’re having a rough day, so you reach for comfort food. And usually, that food is not good for you.

Worse, any excess calories you consume because of high cortisol are more likely to be deposited in your belly. Hello, belly fat!

We can’t eliminate stress in our lives. But we can incorporate regular activities that will help reduce it. We all know this. The problem is we’re not doing it often enough. Schedule it into your day. Relieving stress is just as important as exercising and eating a healthy diet.

Good stress-relieving activities include:

  • Daily exercise
  • Time outdoors in nature
  • A healthy diet
  • Social support
  • Yoga and tai chi
  • Meditation
  • Journaling
  • Pet therapy
  • Music
  • Crafts
  • Deep breathing
  • Anything that helps you feel calm and centered

6. Check your drinking habits.

Though moderate drinking levels aren’t likely to hurt your weight-loss efforts, if you drink more than 1-2 drinks a day, it may be time to re-examine that habit.

Alcoholic drinks contain extra calories that can contribute to weight gain if you’re not careful. In one study of over 7,600 men, researchers found that heavy drinkers (over 30 grams a day) showed the greatest weight gain and had the highest rates of high BMIs over a five-year period. It didn’t matter what type of alcohol they drank.

In another study of nearly 5,000 participants, men who consumed more than 60 grams per day of alcohol were more frequently obese compared with non-drinkers. They were also more likely to have larger waistlines.

Simply drinking alcoholic beverages may also encourage you to eat too much or eat unhealthy foods. In a 2017 study, researchers found that alcohol consumption could lead to “overeating episodes.” Reducing alcohol could help increase willpower when it comes to diet.

How much alcohol can you drink and still lose weight? Scientists attempted to answer that question in a recent 2021 review. They found that beer seemed to have a direct effect on weight gain, particularly waist circumference in men. According to their results, about 16.9 ounces of beer per day could hinder your ability to lose weight.

Lose Weight Sleep

7. Get 7-8 hours of sleep per night to lose weight after 40.

When you don’t get enough sleep, you’re more likely to gain weight. It’s that simple.

There are a lot of reasons for this, mainly because of the way sleep deprivation affects your hormones. But the bottom line is that every time you fail to get 7-8 hours of sleep per night, you’re making it much harder for your body to lose weight.

In a 2017 comprehensive review of the literature, scientists found that individuals who regularly slept less than 7 hours per night were more likely to have higher BMIs and to develop obesity than those who slept more.

Lack of sleep stimulates stress hormones, which as noted above, can lead to weight gain. It also increases hormones related to hunger, making you want to eat more foods high in carbohydrates. Finally, it leads to fatigue, which usually leads to less physical activity.

How do you know how much sleep you’re getting? You can check when you go to sleep and get up, but that’s not always accurate. It doesn’t tell you, for instance, about the quality of your sleep.

I recommend you go a step further and track your sleep. We have technology now that allows you to track not only how long you sleep but helps analyze your sleep patterns so you can improve your sleep schedule and environment.

Check out these tools for comprehensive sleep tracking, then choose one that will work for you and get serious about your sleep!

8. Get stronger.

We talked about muscle loss above, and how it’s related to weight gain.

The good news is that the opposite is often true—gaining muscle loss correlates with losing weight.

Several studies show this to be true. It works because building up your muscles through resistance training changes the way fat cells operate. As your muscles are stressed through lifting, pushing, or pulling, cells release a substance that instructs fat cells to start the fat-burning process.

This change affects the muscles, for sure, but it can also set off a fat-burning response throughout the body. The more resistance training you do, the more you can change your body to support long-term weight loss.

In a study by the Harvard T.H. Chan School of Public health, researchers found that men who performed 20 minutes of weight training each day showed a smaller age-related increase in abdominal fat, compared to men who spent those 20 minutes doing aerobic activities.

Resistance training also helps lower the risk of developing type 2 diabetes. But even if you have diabetes, strength training can help. In one study of older men who had already been diagnosed with type 2 diabetes, two sessions per week of resistance training significantly improved insulin sensitivity and fasting glycemia, and decreased abdominal fat.

Lose Weight Movement

9. Incorporate more daily movement into your life.

Yes, your daily workout is important. But as you age, moving more throughout the day is even more important.

That’s because overall, we are more sedentary than we used to be. In a study comparing 19th– and 21st-century Americans, researchers found a half-hour decline in daily physical activity. They also found that Americans’ resting metabolic rate—the total number of calories burned when the body is completely at rest—has fallen by about 6 percent since 1820.

This, despite our devotion to daily workouts.

In another study published in the American Journal of Epidemiology, researchers found that replacing just 30 minutes of sitting with any kind of movement, every day, could help you live longer. And in a 2018 study, scientists found that standing instead of sitting for six hours a day could prevent weight gain and help people to lose weight.

It can help to keep track of how much time you spend sitting each day, and how much time you spend moving. You may be surprised.

The key to losing weight after 40 is to move more throughout the day. The more you sit, the more your large muscles are not using glucose, which can cause blood sugar levels to rise. Prolonged sitting can also change the activity of genes in such a way that they promote more fat storage.

Try these tips:

  • Set a timer that reminds you to get up and move around at least once every 30 minutes.
  • Incorporate walking into your meetings and outings with friends.
  • Park far away and take the stairs.
  • Adopt a dog.
  • Keep a jump rope in your office.
  • Turn on the tunes and dance.
  • Make it a habit to head out for a walk or play a quick game of catch when you get home from work.
  • Keep exercise equipment available.

10. To lose weight after 40: focus on establishing new daily habits.

If you want one tip to lose weight after 40, this is it: change it up!

What you did a decade or two decades ago is no longer going to work. You have to try something new.

After you talk to your doctor and get tested, sit down with your planner and create a new schedule. When can you cook a homemade meal? Add more resistance training to your schedule? Move more?

On what days will you take a walk or get back to your woodworking to reduce stress? When will you get that new sleep tracker? On what days will you fast for 12 hours or more?

You get the idea. Make some real changes in your life, and you’re likely to be more successful.

Remember—you can contact us for a personalized consultation. We can help you create that weight-loss plan that will be much more likely to work for you.

Men’s Health: How BPC 157 Could Supercharge Your Body’s Healing and Health

How BPC-157 could supercharge your body's healing and health
BPC-157 helps repair tissues and helps your body recover.

I’m getting really excited about peptides.

It’s not just me: the general medical community is coming to understand—if slowly— what a small group of dedicated researchers have known for decades: peptides may be the key to aging gracefully. 

They’re promising for a few reasons. 

The first—and most important—is that they actually seem to work. Unlike many fads in the men’s health and precision medicine space, peptides are walking the talk.

The second is that they work by using your body’s own biology. Rather than introducing a harsh chemical to your system and hoping for the best, peptides are already used by your body to regulate itself. So they fit well in our body’s complex machinery.

And the third reason is that there are so many. There are thousands of peptides known to science, and only a handful have been truly and properly studied. Different peptides have very different effects. There’s a ton of promise. 

This article is about one peptide in particular that is widely used in athletics and by biohackers. It’s called “gastric pentadecapeptide body protection compound” but is more commonly known as BPC-157—“body protection compound”. 

While we’re still learning more about it, the evidence indicates it could be used to greatly boost recovery from injuries, help heal stomach ulcers, and have a number of other protective effects. 

What is BPC-157?

BPC is a peptide, which means it’s a short chain of amino acids—the substances that make up proteins. It’s a pentadecapeptide, which means that it’s made up of 15 amino acids held together by peptide bonds.

BPC is considered a “synthetic” peptide because this particular substance is created synthetically in a lab. But it was derived from a protein that is found in the human body. BPC, chemically, looks like a smaller part of that natural protein.

Peptides are often used by our bodies as chemical messengers. They help regulate a number of different functions and get the body performing at its best. 

Because they’re naturally used by our body, supplementing peptides has become an effective therapeutic technique. The peptide therapies that exist can be used for a number of beneficial uses including to boost the immune system, to help with weight loss and burning fat, and even to reduce inflammation.

What does BPC-157 do?

Well, it appears that it has a number of potential benefits, especially when it comes to helping your body heal and repair after an injury.

BPC-157 speeds up tissue repair

BPC-157 has been found to speed up the healing of lean body tissues like muscle, ligaments, and tendons.

Some of the promising studies on BPC-157 have found that they may be effective in speeding up the repair of ligaments, tendons, muscle tissue, and even the skin. 

For example, in one study, BPC-157 consistently healed damaged ligaments in rats much quicker than if it was not present. The healing was effective, too: it preserved the function and biomechanics of the joint. In another study, BPC-157 was found to kickstart the production of collagen. Collagen helps skin look elastic, and is also essential to joint health, as well as hair and nails. In a further study, BPC sped up bone repair. 

Those results seem to hold across studies. In a 2019 review, researchers found that BPC-157 was consistently able to repair soft tissue injuries across all the research that they reviewed. They noted,

“All of the studies to date that have tested BPC 157 as a treatment therapy have demonstrated extremely positive healing effects for various injury types in a number of soft tissues.”

I should note an important caveat to this research: most of the studies that have been done on this peptide have been done on animals—usually rats. That’s normal:  animal studies are used to get a sense of what a compound does and to get a sense of its safety. That’s partly so that humans are not put at risk, but it’s also because research on animals is much less expensive to do. Then researchers move to humans so they are confident that it could work and when they are willing to invest in much more expensive research.

Since rats have a lot in common with humans, including how our muscles and lean tissues work, the research results for BPC-157 are quite promising. 

But of course, since most of the research hasn’t been conducted on humans, we need to be cautious about making too much of these findings.

BPC-157 helps heal your gut

One of the focuses of BPC-157 research is on its role in contributing to gut health. This is the focus mostly because BPC-157 was originally derived from a protein that is found in the gut. 

Research now suggests that it can have a powerful effect on protecting and healing damaged digestive tissue: it’s been found to inhibit the formation of lesions in the esophagus, stomach, and duodenum. This is especially true of the oral form of BPC-157, which is especially good for the gut. 

BPC-157 route of administration

BPC-157 can be taken orally or it can be injected subcutaneously (just beneath the skin).  It appears to have the most powerful effect on gut health when taken orally, whereas subcutaneous injections are better for reducing systemic inflammation and aiding with tissue repair. BPC-157 can be injected subcutaneously in the lower abdomen, or for better effect in specific joints or muscles, can be injected near the site of concern (for example, you might inject it near the elbow if you wanted to heal an elbow injury). 

BPC-157 reduces harmful side effects of other medications

It can also help protect the gut from other chemicals.

The magic of modern medicine has given us a number of important pharmacological interventions (medications) for a wide range of diseases and medical issues. These are often essential.

But they also may have some harmful side effects. 

For example, haloperidol is a commonly used medication for treating the symptoms of some psychological illnesses like mania and schizophrenia. It’s a very useful drug, but it can also be quite rough on the body. One side effect of haloperidol is that it causes stomach lesions. Stomach lesions are also a side effect of some chemotherapy medications that are used to treat cancer.  

BPC-157 seems to be able to counteract these in many cases, preventing these lesions. That suggests it could be useful as a complementary therapy when these other medications are prescribed.

BCP-157 enhances blood flow

Doctors and scientists suspect that one of the ways BPC works to repair tissue is by increasing blood flow to injuries. After all, blood brings the body what it needs to repair itself: oxygen, nutrients, antibodies, and so on. 

And BPC-157 seems to increase blood flow. There appear to be two ways that it does so. 

The first is by upregulating the expression of growth factor early growth response gene-1 (also called EGR-1). This gene is involved in increasing the amount of blood that flows to wounds.

The second way it does this is by actually increasing the number of blood vessels. The fancy medical terms are angiogenesis (the creation of arteries) and vasculogenesis (the creation of veins). BPC-157 seems to activate vascular endothelial growth factor receptors, which are involved in increasing the number of blood vessels and repairing them. 

This insight comes from in vitro studies, which means studies done on cells isolated outside of the body (imagine scientists looking under a microscope at a petri dish). So, again, we have to be careful not to make too much of these results, since we’re investigating the effects of BPC-157 outside the body.

Still, these results are exciting because they provide a possible explanation for why we consistently see BPC-157 improving the healing and repair of tissues. 

BPC-157 has anti-inflammatory properties

Some studies have found the BPC-157 is an anti-inflammatory. It was found to significantly decrease inflammation in patients with ulcerative colitis, which is a kind of bowel disease. 

Researchers were especially optimistic about the use of BPC-157 as a treatment for inflammation because it didn’t show the same kind of side effects that other commonly prescribed anti-inflammatories have. 

What’s more, BPC-157 seems to be useful in treating both acute and chronic inflammation

BPC-157 seems to be neuroprotective

plastic brain and central nervous system model
BPC may help fight against diseases of the central nervous system and brain.

If that’s not enough, BPC could be a salve for various kinds of traumatic brain injuries. Researchers found that it has neuroprotective effects: it protects somatosensory neurons, it appears to promote peripheral nerve regeneration, and it seems to slow or even reverse the course of traumatic brain injuries from progressing. 

All those effects have led researchers to conclude that BPC 157 could serve as a new soldier in the battle against disorders of the nervous system. 

What about BPC side effects?

It’s important to make it clear that the research on BPC in humans is limited. 

BPC has been found to be safe in clinical trials conducted in several countries, with no toxicity reported. Those results are consistent with the results from the animal studies conducted to date: there haven’t been any instances of toxicity reported. 

But because of the lack of research on side effects, there is still much that we don’t know. That’s why all peptides should be carefully administered under the guidance of a clinical research trial or a qualified physician. Ideally, you’ll want to ensure that you have a doctor who understands the promise and any risks associated with peptide therapy so that you can get well-informed advice. 

Peptides can be part of a systems health approach

Our bodies are complex and massively interrelated. 

How you eat, how you sleep, whether you’re stressed, and your sexual health all are influenced by, and in turn influence, each other. You need all those things to be in place to thrive. You can’t just take a peptide and suddenly feel young and energetic again. 

But peptides can be a part of a systems-based approach to health, just like hormone therapy, a weight loss program, and other forms of lifestyle medicine. BPC-157, in particular, is promising as a way to help repair injured tissues, reduce inflammation, and generally help your body heal itself. It may be a form of peptide therapy that’s appropriate for you.

Remember, always consult a qualified physician before starting a peptide regimen. Most physicians aren’t well-versed in the promising effects of peptide therapies, but some are. Look for a doctor you can trust that understands the complexity of the body and can help you optimize your health and your life. 

BPS-157 might just be a crucial part of that.

 man looking at sunset on mountain, BPC-157 peptide therapy for health
Peptide therapy could be a useful addition to your health regimen. Ask about whether it’s right for you.

Schedule a consultation to learn how peptides can help YOU.

Ready to take the next steps?

Download the Blueprint

Schedule a Call

**************************

In Male 2.0™, Dr. Tracy Gapin has turned everything we once thought we knew about men’s health and performance upside down. The old model of how to be “a man” is broken. A man who works himself to death.  Unfortunately, a man who tries to NOT get sick but isn’t really healthy either.  And a man who takes a pill for every ill but is never really cured. That was Male 1.0. Now, imagine being THE MAN ─ owning your performance in the bedroom, the weight room, and the boardroom. Living a fully optimized life. Becoming limitless. This is Male 2.0!

Tracy Gapin, MD, FACS  is a board-certified Urologist,  world renowned Men’s Health & Performance Expert, Author, and Professional Speaker. Using state-of-the-art biometric monitoring, nutrition and lifestyle intervention, Dr. Gapin coaches Fortune 500 executives and evolutionary leaders of business, sports medicine, and high performance. He specializes in cutting-edge precision medicine with an emphasis on epigenetics, providing men with a personalized path to optimizing health & performance. www.GapinInstitute.com

Want more tips to optimize your health?  Listen to the latest podcasts. Click HERE

References

Cerovecki, T., Bojanic, I., Brcic, L., Radic, B., Vukoja, I., Seiwerth, S., & Sikiric, P. (2010). Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat. Journal of orthopaedic research, 28(9), 1155-1161.

Gwyer, D., Wragg, N. M., & Wilson, S. L. (2019). Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell and tissue research, 377(2), 153-159.

Sikiric, P. S., Seiwerth, S., Rucman, R., Turkovic, B., Rokotov, D. S., Brcic, L., … & Sebecic, B. (2012). Effect of Pentadecapeptide BPC 157 on Gastrointestinal Tract. In Filaretova L. P., &  Takeuchi, K. (Eds.), Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract (Vol. 30, pp. 191-201). Karger Publishers.

Inflammation Makes You Gain Weight. Peptide Therapy Can Help You Lose Weight.

Weight loss is one of the most common health concerns among my clients.

Men struggle with weight loss even though they do all the right things: they go to the gym regularly, they eat a clean diet, they take what they think are the right supplements… but something just isn’t right. 

Losing weight seems like it should be easy if you’ve straightened out your diet and exercise… So, why is it so hard to lose that stubborn fat?

First off, the body is complex.There are a ton of factors beyond diet and exercise that matter for losing weight. Of course, sleep is really important, your hormones and testosterone matter, and stress plays a huge factor. Your microbiome and gut health almost certainly play a role, too. 

And, of course, your genes matter. Not just your actual genetic makeup, but also epigeneticswhich genes are turned on or off at a given time. 

In order to understand weight loss, and men’s health in general, we have to think about the body as a sophisticated system. If you want to lose weight, get more energy, and feel younger, there’s a constellation of factors that matter.

And here’s a big one that people often miss: inflammation. 

In this article, I want to explain the connection between your body’s inflammatory response and the difficulty you may have shedding those extra pounds. And then I’ll tell you how you can address your inflammation with targeted peptides to help you finally lose weight. 

What is inflammation?

Inflammation is your body’s general immune response. There are two main types that we’re concerned with:

  • Acute inflammation is a localized response. It’s what you get when you sprain your ankle and it swells up, gets red, and gets warm. Or when you get an infected cut. Acute inflammation is your body sending in the “good guys” to repair tissue or get rid of toxins. 
  • Chronic inflammation is a longer term, generalized response. It happens when your body’s own white blood cells stick around longer than they need to and start attacking your own body. It’s a deep-rooted, systemic problem. 

Chronic inflammation can have serious health consequences, including increased risk of cardiovascular diseases, cancer, Alzheimer’s, prostate disorders, and more.

But in addition to all those severe health issues, inflammation can also just affect how we feel day to day. It could be what’s sapping your energy and making you feel lethargic.

And, most central to this article, chronic inflammation can make it hard for you to lose weight. 

What are the signs and symptoms of chronic inflammation?

How do you know if you have chronic inflammation? It can be difficult to know, but some of the symptoms include:

  • Being overweight or obese
  • Heartburn, nausea, gas, and other gut problems
  • Fatigue and chronic feelings of being tired
  • Difficulty sleeping
  • Prostate problems
  • Stress
  • Mental fog or emotional instability
  • High cholesterol or blood pressure
  • Pains or weakness in the muscles that don’t have a clear cause

Chronic inflammation often simply looks like a general feeling of being unwell without a clear cause. 

What causes inflammation?

Chronic inflammation is caused by the regular suspects that are related to poor health: a poor diet that’s high in sugars, saturated fats, and trans fats; obesity; stress; and smoking. It can also be caused by periodontal disease, an imbalance of hormones, and inadequate sleep. 

How does inflammation contribute to weight gain?

Inflammation and weight gain go together. 

First, the research suggests that fatty tissue can trigger inflammation. One study found that adipose tissue actually stimulates your body to release inflammatory mediators like interleukin 6 and tumor necrosis factor α. Other research has suggested that overeating can lead to inflammation. So being overweight can contribute to inflammation.

But it works the other way, too: inflammation can cause you to gain weight—and keep it. One way inflammation does that is by changing how we absorb and use the food we eat. Inflammation can actually affect our gut health: it can influence the bacteria that make up our microbiome and even affect how nutrients and energy are extracted from the food we eat. 

For another thing, inflammation may cause us to feel more hungry and to choose to eat foods that are worse for us. And to make matters worse, it also may be one cause of insulin resistance, which makes it more difficult to turn blood glucose into energy.

So being overweight can contribute to chronic inflammation. And inflammation contributes to weight gain. It can turn into a vicious cycle. 

The good news is that you can reverse it: losing weight helps reduce inflammation… and reducing inflammation will help you lose weight. 

How to reduce inflammation

Adopting a generally healthy lifestyle can help reduce inflammation. That means eating a balanced, nutrient-rich diet; avoiding processed foods, sugary, and fried foods; exercising enough; managing your stress; sleeping enough; and quitting smoking. Those are the basics. 

But even after doing all those things, you may find that you need a bit of a boost to lower your inflammation. 

That’s where the strategic use of peptide therapies comes in. 

Peptides can help disrupt chronic inflammation and help you lose weight

The scientific and medical community is only really just becoming aware of how important peptides can be in helping people age well.

Peptides are small chains of amino acids—like proteins, but shorter. 

What do peptides do? Well, there are now thousands of different peptides known to scientists, and there’s a huge variety in the effect that they have. But they often work as chemical signals, helping our body to regulate itself. 

For instance, some boost your immune system; others, like BPC-157, help your body repair tissues; others, like tesamorelin, stimulate growth hormone and help you put on muscle; and yet others, like amlexanox, can reduce inflammation and help burn fat. 

If peptides are made naturally, how does peptide therapy help?

Our body naturally makes peptides, but production of these essential chemical regulators tend to decrease with age. That’s one of the reasons that our body stops functioning properly as we get older.

Peptide therapies and supplements help restore key peptides back to the level you had in your early 20s. And they can bring back the benefits of a younger body: faster healing, faster metabolism, and improved weight loss, among others. 

Amlexanox and weight loss

Amlexanox is one peptide that plays a role in reducing inflammation. That’s why it’s one of the best peptides for weight loss and fat loss

Amlexanox has a powerful anti-inflammatory effect. Traditionally, it’s actually been used to treat stomach ulcers because it reduces healing time and pain. It works in several ways, including by inhibiting the release of histamine and leukotrienes.

But it also has been found to promote weight loss. 

Some research has found that Amlexanox inhibits the TBK1 enzyme, which may enhance the body’s ability to burn fat. It also seems to inhibit IKK-ε, which is an inflammatory mediator. By inhibiting it, Amlexanox improves the metabolism of glucose and improves energy. 

Finally—and this brings us back to epigenetics—Amlexanox seems to “turn off” the expression of “fat genes”

While the research on Amlexanox is still in its infancy, the existing literature does suggest that Amlexanox can have some powerful effects: fighting weight loss and reducing inflammation so you feel your best.

Amlexanox plus TTA give fat a one-two punch

When Amlexanox is used to combat weight gain, it’s usually combined with Tetradecylthioacetic Acid, or TTA. 

TTA is a fatty acid that’s given as a nutritional supplement. When you hear “fatty acid”, you might think that’s a bad thing. But don’t worry—it doesn’t get used by the body for fuel. Instead, it actually helps regulate how the body stores fat.

TTA helps decrease hunger and upregulate metabolism of fat. That means it helps you burn through fat quicker. 

Together, Amlexanox and TTA are an effective fat-fighting duo. 

The men’s health takeaway: Target inflammation to lose weight

The body works together in one big system. That’s why it’s not enough for many people to use a simple equation like, “calories in, calories out”. If it were, weight-loss diets would work and it would be easier to slim down.

To really lose weight and feel healthy, you need a systems approach.

It turns out that a very significant contributor to gaining weight from fat is inflammation. That means that if you’re trying to lose weight, you want to do what you can to minimize inflammation. Some things you can do yourself, like eating well and getting enough sleep. 

 

But you might also want to power-up your own efforts with a tailor-made plan from an expert in peptide therapies. A personalized medicine plan that includes the strategic use of peptides like Amlexanox may be exactly what you need to get your body working at its best.  

Schedule a consultation to learn how  peptides can help you lose weight. 

Ready to take the next steps?

Download the Blueprint

Schedule a Call

**************************

In Male 2.0™, Dr. Tracy Gapin has turned everything we once thought we knew about men’s health and performance upside down. The old model of how to be “a man” is broken. A man who works himself to death.  Unfortunately, a man who tries to NOT get sick but isn’t really healthy either.  And a man who takes a pill for every ill but is never really cured. That was Male 1.0. Now, imagine being THE MAN ─ owning your performance in the bedroom, the weight room, and the boardroom. Living a fully optimized life. Becoming limitless. This is Male 2.0!

Tracy Gapin, MD, FACS  is a board-certified Urologist,  world renowned Men’s Health & Performance Expert, Author, and Professional Speaker. Using state-of-the-art biometric monitoring, nutrition and lifestyle intervention, Dr. Gapin coaches Fortune 500 executives and evolutionary leaders of business, sports medicine, and high performance. He specializes in cutting-edge precision medicine with an emphasis on epigenetics, providing men with a personalized path to optimizing health & performance. www.GapinInstitute.com

Want more tips to optimize your health?  Listen to the latest podcasts. Click HERE