Men’s Health: Reverse Aging with NAD+

Aging is inevitable – but there’s a whole new frontier for optimizing our health through the latest genetic science and biohacking that can help you to slow down the aging process and maybe even reverse aging with NAD+.  NAD (short for nicotinamide adenine dinucleotide and also known as NAD+) has recently been getting a lot of attention as a cutting-edge tool to promote longevity.  

We’re taking it all the way down the cellular level here.

Properly functioning cellular metabolism is essential to health. The sum of every chemical reaction that happens inside the body, along with its molecular interactions, keeps the body in a state of balance. This is all made possible by coenzymes (“helper molecules”) and specific proteins acting as metabolic sensors that respond to conditions in the cells and body. NAD is a tiny coenzyme that plays an important role in this delicate dance. As you age, NAD+ decreases and with it goes cellular function that prevents disease and maintains vitality.

What is NAD+ and why is it important?

NAD+ is vital to cellular metabolism because it turns nutrients into cellular energy. It also activates a set of proteins called sirtuins that regulate cellular health. NAD+ creates the cellular energy that helps us to retain our youthful function, muscle strength, and physical stamina. When sirtuins were discovered they were quickly nicknamed “the longevity genes.” 

A fascinating aspect of NAD+ is its dual role in protecting against the factors that age us. This includes inflammation, DNA damage, and failing mitochondria (cell respiration). NAD+ promotes longevity by facilitating DNA repair and protecting mitochondria from early death. As a result, NAD lowers the risks for age-related brain diseases like Alzheimers or Parkinson’s and cardiovascular diseases (a leading cause of death for men). 

NAD is the building block for ALL of our systems such as the lymphatic, cardiovascular and nervous systems. It is responsible for our immune function, insulin regulation, and fatty acid oxidation. Without it, we would literally die!

Improving Health Through NAD+ Boosting Photo Credit: The Sinclair Lab

NAD+ and Aging

A NAD+ molecule isn’t consumed alone to create energy like fuel in a car. Instead, it works with proteins to carry out essential biological processes like cellular energy creation and maintaining healthy DNA. Sirtuins are some of the proteins that play a key role in these processes. They only function in the presence of NAD+ and this means that the body needs to constantly synthesize it to maintain cellular function. However, NAD levels markedly decline with age, creating an energy deficit that decreases the body’s ability to retain optimal health.

Sirtuins and NAD+ work together to help promote overall health.

For example, at age 50 a typical person may have only half the NAD+ they did in their younger years but by age 80, NAD+ levels drop to only 1-10 percent of the levels measured in youth. But recent studies have now shown that increasing NAD+ in the body can restore the body’s cellular function as though turning back time – actually slowing down the aging process. Essentially, men can reverse aging by restoring healthy levels of NAD+.

One study done on mice, showed an average 5 percent increase in their lifespan —even though supplementation did not begin until the mice were nearing the end of their natural lifespan of 24 months. That would be the equivalent of gaining nearly an additional four years of life to today’s average human expectancy of 79 years!

Another side effect of decreased NAD+ is that muscles begin to shrivel and grow weaker due to vascular aging (thinning and aging of blood vessels, reducing cellular health). Vascular aging is responsible for many disorders for men.  These may include cardiac and neurologic conditions, muscle loss, and impaired wound healing. The process can be slowed down with regular exercise, but gradually even exercise becomes less effective at holding off this weakening.  In further research findings, mice with NAD+ supplementation showed between 56 and 80 percent greater exercise capacity. This points to a reversal in vascular aging and an ability to maintain a youthful physical stamina. 

Furthermore, in two different animal models of neurodegenerative disease, increasing cellular NAD+ reduced the severity of the disorder, normalized neuromuscular function, and delayed memory loss.  Most studies started on mice, but more recently clinical studies have shown positive effects on humans. You can begin to see how crucial NAD+ is to a vital life – and how its depletion can rob you of this vitality as you age.

Reversing Aging with NAD+ Precursors

Most of the ways of increasing NAD+ do not include supplementing with NAD+ itself, but rather precursors to NAD+. There are 5 precursors to NAD+:

  • tryptophan
  • nicotinic acid (pyridine-3-carboxylic acid)
  • nicotinamide (nicotinic acid amide)
  • nicotinamide mononucleotide (NMN)
  • and nicotinamide riboside (NR).

We can get NAD+ in our bodies through diet.  This is done by consuming foods with NAD+ precursors in them – like fish, crimini mushrooms, and raw green vegetables. However, you can’t really eat enough of anything to significantly boost NAD+ levels. Taking a NAD+ precursor supplement can help mitigate the decline, improve cellular health, and even mitigate loss of telomeres.

NMN and NR are the most popular precursors found in the latest anti-aging supplements. However, NR (a unique member of the vitamin B3 family) has been found to be the most efficient. If you’re a wine fan, you may be familiar with another famous anti-aging compound: resveratrol. NR is 4x more bioavailable than resveratrol, quickly kicking the red-wine derivative to the curb.

It has a positive impact on Metabolism

NR doesn’t just have anti-aging effects, it has a positive impact on metabolism. Mice on high-fat diets with NR supplementation gained 60 percent less weight than they did on the same diet without NR. In addition, none of the mice on NR showed signs of diabetes. Instead, their energy levels improved. 

Nicotinamide adenine dinucleotide (NAD+) is an important target to extend lifespan and health span.

NAD+ Supplements

Renowned Harvard University geneticist David Sinclair is the pioneer in the supplementation business of NAD+ with Elysium Health. Although his anti-aging claims were first met with controversy because most studies had been done on mice (https://khn.org/news/a-fountain-of-youth-pill-sure-if-youre-a-mouse/), the study arena has since been expanded to human trials done at the Mayo Clinic and the University of Washington.  Gaining support of researchers at the top of their field, these human studies point to the same benefits found in our small furry friends.

Dr. Sinclair has conducted a study to show the effectiveness of his supported supplement, Basis.  Previous studies had shown an increase in NAD+ over a 24 hour period. His study sought to determine whether cellular NAD+ levels could be sustained over the entire study period of eight weeks, and it did.

In a placebo-controlled trial of 120 healthy adults between the ages of 60-80, participants taking the recommended dose of Basis saw cellular NAD+ levels increase by an average of 40 percent over baseline after 30 days, sustained at this number to 60 days. Participants taking twice the recommended dose saw those levels increase by 90 percent after 30 days and 55 percent at 60 days. 

ChromaDex, another leading anti-aging company has taken the running lead in scientific support for their supplement TruNiagen. With over 100 preclinical trials, 5 published studies and 3 FDA safety reviews, the evidence surrounding NAD+ supplementation is overwhelming.

It was previously thought that NAD+ could not be given in oral form and only intravenously due to poor bioavailability and low intestinal absorption.  Newer research shows that oral forms of NAD+ supplementation do have positive effects.  NADOVIM is one of the first and earliest supplements on the market to contain actual NAD+ instead of NAD+ precursors in its formulation. https://nadovim.com/top-5-reasons-to-take-nadovim-a-doctors-perspective/

Researchers are still willing to explore the value of IV infusions of NAD+. This is a new area for further, detailed study and could potentially be an effective delivery method in some ways. Preliminary animal study evidence suggests that intravenously administered NAD+ may hold some interesting promise. Currently, there are no pre-clinical or clinical human studies, but this is a fast-moving advancement in what we are learning about the way NAD+ and NAD+ precursors are processed in tissues and across the blood-brain barrier. Stay tuned.

How to Increase NAD+ Levels Naturally

Before you go out and buy a Vitamin B3 or NR supplement, remember that reversing aging requires a systems-based, holistic approach. There is no such thing as a magic anti-aging pill. NAD+ treatment in addition to other lifestyle changes and structures is what ultimately adds more years to your life. It is important to take a high quality NAD+ supplement.  Also, here are additional recommendations to ensure you increase NAD+ and its anti-aging effects.

Fasting

Fasting, or reducing your calorie intake for extended periods, is an excellent method for indirectly boosting the body’s NAD+ levels. It has been shown that, fasting is effective in increasing NAD+ levels.  However, a drastic reduction in calorie intake or fasting long term can have a counterproductive effect. Consider intermittent fasting or adopting a low carb-ketogenic diet to provide similar positive results.

Exercise

Exercise is one of the easiest and most cost-effective methods for boosting NAD+ levels. In a nutshell, exercise forces our body muscles to produce more mitochondria. The increased production of mitochondria results in a natural boost in NAD+ levels in the body.

Sunscreen

Research has shown that too much direct sunlight exposure can deplete the body of NAD+ because our body uses NAD+ to repair sun damaged cells from over exposure to UV rays. Reduce exposure to strong sunlight and wear sunscreen.

Healthy Diet

Eating a well balanced whole foods diet full of NAD+ precursor rich foods is a one-way ticket to reversing aging. Be sure to add more of the following into your diet: 

  • Fish – Varieties of fish like tuna, salmon and sardines are rich sources of NAD+ for the body. Be sure to source your fish from sustainable, wild-caught sources.
  • Green Vegetables – green vegetables contain all sorts of nutrients in them which are beneficial in a variety of ways including NAD+ precursors. Of these vegetables peas and asparagus have the highest amount.
  • Whole Grains – high in Vitamin B3 which also contains RN. Remember that vegetables and grains that are cooked or processed lose their nutrition as well as the vitamin source. Therefore, it is recommended that you should also eat raw vegetables and choose whole grains (rice, quinoa, etc) over processed foods such as chips and cereals.
Reduce Alcohol Intake

Alcohol interferes with healthy cellular processes and reduces the efficacy of NAD+. In fact, alcohol consumption has been shown to directly reduce levels of NAD+ (and testosterone) in the body. 

NAD+ precursors, exercise and caloric restriction can increase NAD+ levels.
NAD+ helps you get energy out of the food you eat, it protects cells from stress, it maintains healthy sleep cycles and it helps your cells repair damaged DNA.

Conclusion 

If you are looking for supplements that reverse aging, the NAD+ research is very promising.  It should be considered as a part of a holistic health plan for every aging male.  Without exercise and a whole foods diet, NAD+ supplementation will have minimal effects. For men who are looking to take their performance and health to the next level, NAD+ can give you that extra edge.

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COMING SOON TO AMAZON

In Male 2.0™, Dr. Tracy Gapin has turned everything we once thought we knew about men’s health and performance upside down. The old model of how to be “a man” is broken. A man who works himself to death. A man who tries to NOT get sick but isn’t really healthy either. A man who takes a pill for every ill but is never really cured. That was Male 1.0. Now, imagine being THE MAN ─ owning your performance in the bedroom, the weight room, and the boardroom. Living a fully optimized life. Becoming limitless. This is Male 2.0!

Tracy Gapin, MD, FACS  is a board-certified Urologist, Men’s Health Expert, Author, and Professional Speaker. Using state-of-the-art biometric monitoring, nutrition and lifestyle intervention, Dr. Gapin coaches Fortune 500 executives and evolutionary leaders of business, sports medicine, and high performance. He specializes in cutting-edge precision medicine with an emphasis on epigenetics, providing men with a personalized path to optimizing health & performance. www.SmartMensHealth.com 

Transform Your Body In 24 Hours With Intermittent Fasting


Intermittent fasting (IF) has become a craze in the health and nutrition world in recent months… and I’m thrilled to see it’s finally becoming more widespread! Short-term fasting has proven beneficial for years, and IF diet-supplementation is finally getting the props it deserves.

So what is intermittent fasting? What are the benefits?

And how can you implement intermittent fasting to start seeing benefits instantly?

What is intermittent fasting?

What you put into your body isn’t the whole story. Your body responds to more than just calories. When you eat, how often you eat, and how you consume your food also plays a significant role in how your body responds to and uses your food-based nutrients. This is where the idea of intermittent fasting comes in.

Intermittent fasting is a dietary practice that limits the number of calories you consume in a daily or weekly period. While other dieting practices focus on what you eat, IF focuses on how you eat.

IF is not the same as starving yourself. Rather, it restricts your food consumption to a specific window of time. This “feeding” period ensures you still receive the proper daily nutrients your body needs for healthy functioning. Then the “fasting” period—the time in between meals—helps your body use those nutrients to reset and rejuvenate for optimal health.

There are a number of forms of intermittent fasting, which we’ll discuss below in our IF diet plans. But first… why should you even hop onboard the IF train?

What are the benefits of intermittent fasting?

1. Boosts weight loss

Maintaining a healthy weight is crucial to overall health. Obesity is linked to a number of serious and chronic diseases like cardiovascular disease, diabetes, high blood pressure, gallbladder disease, arthritis, gout, and even cancers. Maintaining a healthy weight is also crucial to hormone regulation and a functioning endocrine system. This is especially important for men who are suffering from symptoms of low testosterone or erectile dysfunction.

Intermittent fasting can help improve your weight loss efforts in two key ways.

Firstly, your body uses food as its energy source. When fasting, your body still needs energy in order to function. When you’re not consuming energy through food, your body has to tap into its energy storage—aka your fat reserves.

Basically, your body has to burn fat in order to stay functioning while fasting. This can help you shed those extra few pounds that seem to be hanging on for dear life.

Secondly, fasting helps to limit the number of calories you consume. Your body physically can only eat so much in a period of time. This means that if you take away hours of the day where you could be consuming food, you naturally drop your caloric intake.

For example, say your body could consume 1,000 calories per meal. That’s 3,000 calories per day. If you fasted for one of those meals, you’re down to only 2,000 calories. Fast for two meals and you’re at a third of your caloric intake for that day.

This is especially useful for people who are overweight and have a tendency to eat a lot at one sitting. Cutting back on the meals you eat in one day can help you drastically cut your number of calories. Over time, your stomach will start to shrink and your body will crave fewer calories.

You’ll be eating less and burning more!

Note that too much fasting can actually have a negative effect on weight loss. Fasting too frequently or too long can actually put your body into “starvation mode.” Your body then thinks it’s starving, so it will actually hold on to your fat as a way of protection. This is why the practice is called intermittent fasting.

2. Improves workouts

Intermittent fasting can actually improve the efficacy of your workouts, which can then lead to increased weight loss and healthier functioning.

Working out in a fasted state can help build muscle during resistance training. Furthermore, eating post-workout after fasting promotes a faster absorption of nutrients. Two-for-one benefits just by fasting before a workout and eating after!

One study found that when weightlifters underwent 16 hours of fasting, their fat mass decreased significantly… but their muscle mass stayed the same. This means that fasting doesn’t “kill your muscles” as some Negative Nancies would have you believe.

Although the benefits of intermittent fasting are most pronounced for resistance training, IF also has benefits for aerobics and endurance as well. One study found that fasting can even improve training performance while running.

3. Gets rid of toxins


Intermittent fasting helps boost the body’s natural cell death process, which kills off toxic cells and promotes the rebirth of healthy ones.

This is the process of autophagy, which is when unhealthy cells devour themselves. This helps rid the body of toxicity, which can help reverse the aging process and prevent certain diseases. If this process isn’t activated, then damaged cells will hang around and harm the healthy cells. This can lead to cancers (like prostate cancer), growths, inflammation, and other diseases. Autophagy basically cleans out the bad cells, so fresh, healthy cells have room to be born.  

Intermittent fasting can initiate this autophagy process.

In fact, there have been several preliminary studies on the effects of intermittent fasting on cancer patients. A 2009 study found that fasting could help reduce the side effects from toxic chemotherapy. Patients also reported a higher quality of life post-treatment. This response is likely because fasting can help preserve lean body mass while promoting the death of toxic cells (aka those cells that are damaged by chemo).   

Another study concluded that “calorie restriction or fasting demonstrates a wide range of beneficial effects able to help prevent malignancies and increase the efficacy of cancer therapies.”

This research insinuates that intermittent fasting may be able to help protect the body from toxicity.

Those are three pretty consequential benefits of intermittent fasting. Lose weight, have more productive workouts, and get rid of toxins. Plus, these effects then lead to enhanced energy, mental clarity, concentration, hormonal balance, and more. Think of IF as the ultimate “reset” for your body when it’s feeling sluggish.

So how can you implement intermittent fasting in your life so you can reap these awesome rewards?

What are the types of fasting?

There are a number of fasting approaches. I recommend starting with the first approach and working your way up to the last to avoid “shocking” your body. Keep in mind that IF works differently for each person, so you’ll want to find the approach that best fits with your body’s rhythm.

1. Skipped meals

Start by skipping one meal. This will help your body fast for an extra period of time in an easy, convenient way.  

The best meal to skip is breakfast. This means you’ll have fasted for the entire nighttime and morning, which can be a fast of up to 12 hours. In fact, look at the word breakfast: it’s literally the meal that breaks your fast from a night of not eating. If you skip breakfast, you can hold off on breaking that fast just a little bit longer.

You can skip meals once a day, once every other day, or once a week. For this approach, the more frequent the fasting, the more you’ll see the effects.

2. Eating windows

This type of fast lengthens the number of hours you go without food, while still allowing for 1-2 meals during fast days. This type of intermittent fasting condenses your caloric intake to a window between 4 and 7 hours. The rest of the day (and night), you’ll be fasting. It’s most common to fast between 5pm and 11am or 6pm and 12am. This means basically skipping two meals—dinner and breakfast—and eating a heartier lunch.


3. Warrior fast

A similar fast is the “warrior” approach by Ori Hofmekler. This condenses the eating window to four hours at dinnertime, when you’re encouraged to “feast.” The rest of the day you should be fasting or only eating raw fruits and veggies.

This is my favorite type of intermittent fasting for big events (like Thanksgiving). Fast all morning, and then you can indulge in a delicious Thanksgiving dinner without too much guilt. (But this isn’t an excuse to eat 10,000 calories in mashed potatoes. Sorry!)   

4. 24/48 hour fast


These are the most common type of fasts for consistent fasters. The 24/48 hour fast is when you avoid eating food for a full day or two.

While fasting for a full day, you are usually permitted to have light liquids, raw veggies, and a small piece of protein like chicken. This usually allows for about 500-600 calories per day. Avoid caffeine, alcohol, refined sugars, and processed foods.

This can be a challenge for the inexperienced faster. Start with shorter periods of fasting, like 18 hours, and work your way up to a full 24 or 48 hours.

5. 5:2 fast

This is then related to the 5:2 fast, where you eat regularly for 5 days and fast for 2 days. The two fasting days can be consecutive—one 48 hour fast—or on opposite sides of the week—two 24 hour fasts. Follow the same rules as the 24/48 hour fast above.

6. Alternating fasts

An Obesity Reviews study looked at participants who alternated fasting for 24 hours and eating regularly for 24 hours. This was a consistent, consecutive alteration for 12 weeks. They found that these participants preserved more muscle mass than their dieting counterparts (those participating in a low-calorie diet). They also ate fewer calories, lost more weight, and saw improved energy.

If you’re comfortable with intermittent fasting, you can consider trying out an alternating schedule. This means that you have one day of eating as usual, followed by 24 hours of fasting. Then eating as usual, and then 24 hours of fasting.

7. Extended fasts

Some people will also do extended fasts a few times per year. These can be 3-5 days, eating less than 600 calories per day. This can be used in conjunction with other intermittent fasting approaches or on its own. However, this brings with it worries of “refeeding syndrome” for inexperienced fasters, which we’ll discuss below.

Determining the type of fast and the frequency of fasting is entirely up to you. Listen to your body. Try out different forms. When you feel the best, you’ve found your intermittent fasting schedule!

Need an intermittent fasting calculator?  Click here

What are the concerns with intermittent fasting?

Many critics of IF claim refeeding syndrome as a serious complication for fasters. Refeeding is when your body goes from 0 to 60—fasting to feeding—too quickly. Basically, it causes electrolytes and blood sugar levels to spike, which can cause serious sickness. However, refeeding syndrome is rare for any fasting length under 3 days and highly uncommon under 5 days.

Avoid any problems by just taking it slowly. If you’re new to fasting, don’t start with a 3-day cleanse. Take it slow and work up to larger fasts. Also, don’t guzzle food after an extended fast. Start with a small, healthy meal of salad and cold water fish. This will help break your fast and give your body the nutrients it needs without causing any unhealthy spikes.

Another “concern” is simply the mental roadblock that comes with not eating. When you first start fasting, your body will be begging for food. Your brain will try to trick you into thinking it’s starving… simply because it likes food! Our brains are conditioned to crave food to keep us alive.

But you can go for days without food and not harm your body. Mahatma Gandhi survived for 21 days without food. One monk even went for 36 days. You can handle 24 hours, trust me.

When you first start fasting, you’ll be thinking about food a lot. So do something to take your mind off of it. Have fun with your friends and family. Watch a movie. De-stress.

Go for a walk. In fact, walking actually helps boost the benefits of intermittent fasting, because it helps you use up additional energy to burn fat and kill toxic cells.

Enjoy the fast.

Once your body adjusts to fasting, you won’t be as hungry as you used to be. You’ll be more energized, healthy, happy, and ready to take on the world around you!

Psst… Don’t forget to drink a lot of water while you’re fasting! Water can help curb appetite and keep you energized.

The Bottom Line

Intermittent fasting is a healthy way to rejuvenate your body instantly. IF can help you lose weight, improve your workouts, and detox your cells for a better functioning brain, endocrine system, autonomic nervous system, immune system, and more. Your body will thank you.

Intermittent fasting is just one step of the Gapin Institute full-body transformation. If you want to start living your best life now, you need to sign up for our Male 90X program. I guarantee you’ll be thrilled you did!