Men’s Health Expert Dr. Tracy Gapin: Testosterone, ED, & How They Affect Everyone​


Dr. Tracy Gapin is a renowned urologist and male health specialist who has dedicated his career to helping men optimize their health and performance. In a recent conversation, Dr. Gapin and his interviewer discussed the culprits of declining or poor health, including erectile dysfunction. They emphasized that many of the same factors that impact men’s libido and ability to perform also impact most people’s health. Therefore, Dr. Gapin’s approach to health and healthcare is beneficial for all humans.

During the conversation with Gabby Reece, Dr. Gapin shared insights on a range of topics, including how a simple mouth swab can help individuals determine the best diet based on their genetics. He also discussed ways to turn back the aging clock, navigate hormone supplementation, and which types of blood workups to ask your physician about.

The conversation also touched upon the impact of watching too much pornography and how it can destroy real-life sex life. Dr. Gapin provided tips on how to pull back and maintain a healthy balance.

At the end of the show, Dr. Gapin generously invited listeners to access his book and other valuable resources. His personalized approach to health and healthcare has helped countless men achieve optimal health and performance.

Overall, Dr. Gapin’s insights and recommendations are invaluable for anyone looking to optimize their health and well-being. His expertise in male health and urology make him a leading authority in the field, and his compassionate approach to patient care sets him apart from other healthcare providers.

ED Myths and Facts: What you need to know

ED Myths and Facts Blog | Gapin Institute

I’m a urologist. That means that I was specially trained in the management of men’s health issues, including low testosterone, prostate health, and erectile dysfunction. This is my passion. 

In my 25+ year career, I have found that among all the men’s health issues I manage, erectile dysfunction is one of the most common complaints that brings men to see me. 

It’s the bread and butter of my work. 

Unfortunately, there’s a ton of misinformation around both what causes ED and how to treat it. Sometimes, that misinformation cause guys to needlessly suffer and avoid seeking guidance and support. 

So I want to take this opportunity to dispel some of the most common erectile dysfunction myths and give you the facts. And then I’ll tell you how to get treatment.

Myth #1. “ED isn’t a real health problem.”

Fact: ED can be a sign of much more significant health problems. 

Men tend to think of sexual issues as performance issues and not necessarily true health issues. But problems with sexual function are potentially a sign of much bigger issues. 

ED is often the initial symptom of vascular disease. The blood supply to the penis is quite small, so any atherosclerosis, or plaque in your arteries, can quickly affect normal blood flow and thus cause issues with normal erectile function. 

Erectile dysfunction can be a sign of underlying diabetes, high blood pressure, or other health problems. So think of ED as a “canary in the coal mine” for other potentially serious health conditions. ED can in fact also be associated with early mortality.

I consider ED to be a wake-up call. It should prompt a full evaluation to identify undetected cardiovascular disease or other health issues that need to be addressed.  

Myth #2. Erectile dysfunction only happens in older men

Fact: Erectile dysfunction is more common in older men, but it can happen at any age. 

Yes, ED is more commonly associated with older men. But younger men can absolutely experience erectile dysfunction, as well. In fact, about 25% of guys under 40 experience ED. 

In younger men, ED tends to be more often related to psychological issues or low testosterone, whereas ED in older men is more commonly associated with underlying medical issues such as cardiovascular disease or diabetes.

Myth #3. ED is a normal part of the aging process, so I shouldn’t worry about it

Fact: No one should “settle” for ED.

older man ED blog photo | Gapin Institute

While ED may be common,  we shouldn’t see it as a “normal” part of aging. 

It can be caused by a number of underlying health issues – poor blood flow, hormone imbalance, or nerve damage. But these are issues that can be prevented by prioritizing an optimal lifestyle.  It’s a health issue. And it can be treated. 

There’s no reason you can’t enjoy an active and satisfying sex life as you age. ED may affect lots of men, but that doesn’t mean we should consider it a normal part of the aging process.

Myth #4. ED means you’re not attracted to your partner

Fact: Some people experience ED even when they are very attracted to their partner. 

Erectile dysfunction is complex and can be caused by a number of factors. In addition to medical issues such as peripheral vascular disease and low testosterone, it can also be a result of psychological issues like stress and anxiety. Even lifestyle factors and some medications you’re taking can kill your sex life

So it’s important to realize that ED is not the same as sexual desire. ED doesn’t necessarily cause low libido and vice versa.

Myth #5. ED is caused by tight underwear

Fact: There is no evidence for a connection between your underwear and sexual function. 

It’s true that there is a link between tight underwear and infertility. This is because the testicles regulate their temperature by getting closer to, or further from, the body. Tight underwear can keep the testicles to close the body, which can increase their temperatures enough to reduce sperm production. 

But infertility is a separate issue from ED. There’s currently no evidence for a link between ED and your underwear. 

Myth #6. Any difficulty getting an erection means you have ED

Fact: It’s normal to occasionally have difficulty getting an erection. 

There’s a kind of social pressure to be “ready” all the time… but that’s not always how our body works. 

Sexuality is complicated and impacted by a lot of factors. Men who are sleep deprived, particularly stressed, or just “not in the mood” may not be able to get an erection on command. That’s actually normal—it doesn’t necessarily mean that they have ED.  

ED is diagnosed when a man consistently has difficulty getting or maintaining an erection satisfactory for intercourse. 

Myth #7. ED means you have problems in your relationship

Fact: While relationship issues can impact your sexual performance, there are many other potential causes as well.

ED Myths and Facts | Gapin Institute

Most cases of ED have physiologic causes, not psychological ones.

Sure, relationship issues can cause stress, anxiety, which could lead to ED. But relationship issues are usually not the cause of most men’s ED. 

Myth #8. ED can’t be fixed

Fact: We have very effective treatment options for ED. 

It’s fairly common that men feel like their ED is hopeless and will never get better. The fact is there are many highly effective treatment options available for ED, and almost all cases of ED can be treated. And not just with Viagra!

Myth #9. The only treatment for ED is Viagra or Cialis

Fact: There are many options for treating ED. 

Viagra, Cialis, and the other oral medications completely shifted ED treatment by increasing awareness and providing an easily accessible solution. But there are many other treatment options as well. This includes vacuum device, intracavernosal injections, peptide therapy, GAINSWave, PRP (Platelet-rich plasma, or ‘P-shot’), and Testosterone or hormone replacement therapy for men with low testosterone.

It’s also important to realize that lifestyle changes can dramatically improve your sexual function. Focusing on proper nutrition, good sleep quality and duration, exercising, and effectively managing your stress are part of a systems-based approach to health that has been proven to improve erectile function.

Myth #10. ED is too embarrassing to talk about with my doctor

Fact: ED is a very common issue with men today, even in younger men, and you should feel comfortable discussing it with your doctor.

One of the biggest issues with ED and other sexual health issues is that guys don’t like talking about it.  It can be awkward. But ED doesn’t mean you’re weak. It doesn’t make you less of a man. It just means you need a little help. 

Fact: You can overcome ED

Erectile dysfunction is a real medical condition and it can be serious. If you’re struggling with ED, seek treatment.

But don’t wait for your appointment to make some lifestyle changes that we know help improve erectile function:

  • Quit smoking
  • Eat a balanced, nutrient-rich diet
  • Cut out trans fats, saturated fats, and excessive sugar
  • Exercise regularly
  • Get enough sleep

If you do those things, you’ll set yourself up for success.  If you need help with ED, reach out to me.  

Schedule a consultation to discuss ED treatment.

Take the next steps

Schedule a Call


In Male 2.0™, Dr. Tracy Gapin has turned everything we once thought we knew about men’s health and performance upside down. The old model of how to be “a man” is broken. A man who works himself to death.  Unfortunately, a man who tries to NOT get sick but isn’t really healthy either.  And a man who takes a pill for every ill but is never really cured. That was Male 1.0. Now, imagine being THE MAN ─ owning your performance in the bedroom, the weight room, and the boardroom. Living a fully optimized life. Becoming limitless. This is Male 2.0!

Tracy Gapin, MD, FACS  is a board-certified Urologist,  world renowned Men’s Health & Performance Expert, Author, and Professional Speaker. Using state-of-the-art biometric monitoring, nutrition and lifestyle intervention, Dr. Gapin coaches Fortune 500 executives and evolutionary leaders of business, sports medicine, and high performance. He specializes in cutting-edge precision medicine with an emphasis on epigenetics, providing men with a personalized path to optimizing health & performance.

Want more tips to optimize your health?  Listen to the latest podcasts. Click HERE


Fung, M. M., Bettencourt, R., & Barrett-Connor, E. (2004). Heart disease risk factors predict erectile dysfunction 25 years later: the Rancho Bernardo Study. Journal of the American College of Cardiology, 43(8), 1405-1411.

Shamloul, R., & Ghanem, H. (2013). Erectile dysfunction. The Lancet, 381(9861), 153-165.

Yafi, F. A., Jenkins, L., Albersen, M., Corona, G., Isidori, A. M., Goldfarb, S., … & Hellstrom, W. J. (2016). Erectile dysfunction. Nature Reviews Disease Primers, 2(1), 1-20.

Capogrosso, P. M.D., Colicchia, M. M.D., Ventimiglia, E. M.D., Castagna, G. M.D., Clementi, M.C. M.D., Suardi, N. M.D., Castiglione, F. M.D., Briganti, A. M.D., Cantiello, F. M.D., Damiano, R. M.D., Montorsi, F. M.D., Salonia, A. M.D. (2013). One Patient Out of Four with Newly Diagnosed Erectile Dysfunction Is a Young Man—Worrisome Picture from the Everyday Clinical Practice. The Journal of Sexual Medicine, 10(7), 1833-1841.

Parazzini, F., Marchini, M., Luchini, L., Tozzi, L., Mezzopane, R., Fedele, L. (1995). Tight underpants and trousers and risk of dyspermia. Internaitonal Journal of Andrology, 18(3), 137-140.

How Environmental Toxins Can Crush Your Testosterone

Environmental toxins to testosterone blog photo | Gapin Institute

Testosterone Crushing Environmental Toxins and What You Can Do About It Blog | Gapin Institute

Let me tell you about a patient of mine—Joe—a 49-year-old executive who came to me for low testosterone

He wanted testosterone replacement therapy because he was suffering. 

He’d been happily married for 10 years. But over that time, he noticed declining energy, trouble focusing at work, and fatigue. His personality and mood had changed, and he had diminished sex drive so wasn’t interested in being intimate with his partner. 

And when they were intimate, things didn’t work as they should…

Joe just wasn’t the man that he used to be. 

Eventually, his marriage failed and he struggled at work. Joe’s lack of energy and inability to focus meant that he made mistakes. He performed poorly and he actually lost his job. 

After I checked some basic labs, I found his testosterone levels were markedly lower than they should be, which explained a lot of his issues.

This is very common in men like Joe, and even guys in their 20s, 30s, and 40s. They present with the same symptoms: lack of energy, low libido, fatigue, weight gain, and inability to focus. 

It’s important to point out that the problem with low T isn’t just related to normal sex drive and performance or building muscle. Healthy testosterone levels are necessary for cognitive function and mental focus. Testosterone is needed for optimal cardiovascular health, bone density, and even longevity. It is essential for quality of life.

The consequences of low testosterone are massive. 

And it turns out that it’s not just Joe who’s experiencing it. Testosterone is decreasing at a population level. This article will explain why we’re losing our testosterone and what we—as individual guys—can do about it. 

The Problem: Population-Level Changes in Hormones and Fertility

I’m not kidding when I say that men are under attack. We are experiencing a testosterone and fertility pandemic. As I declare in my book Male 2.0, at the current rate, in twenty years the entire male population will be sterile and impotent.

A Testosterone Pandemic

We started to clearly see the problem in the 1990s.

One of the watershed studies on the subject was the Massachusetts Male Aging Study. The study looked at the hormone levels of several large cohorts of men and looked at how they changed over time. 

The study found that men had decreasing levels of testosterone as they age. That wasn’t a surprise—we already knew that testosterone tends to decrease as we get older. 

But the real finding was that testosterone levels were decreasing in age-matched cohorts, too. In other words, a 55-year-old man in 2004 had 17 percent less testosterone than a 55-year-old man in 1987. And free testosterone, which is much more significant and impactful, dropped by over 45%! 

So it’s not just age: we’re seeing testosterone in age-matched men declining. 

These results have been consistent across research studies, and not just in the US.

Decreased Testosterone Isn’t Only Due to Lifestyle Changes

Now, we know that lifestyle factors affect the endocrine system and testosterone levels. Poor diets, low exercise, obesity, smoking—these are all known to reduce testosterone. 

And people are increasingly obese. As a population, we’re not exercising nearly as much as we should. Could that be the reason for the decreases in Testosterone?

Those factors almost certainly have an effect, but the studies mentioned above actually accounted for these differences, and can’t explain the entire effect. So something else must be going on. 

Declining Fertility

It’s not just testosterone, either. Research has consistently found that sperm counts and fertility in men are steadily declining, at least in the Western world. 

In her book, Count Down: How Our Modern World Is Threatening Sperm Counts, Epidemiologist Dr. Shanna Swan meticulously details the research and evidence for declining fertility. Her team finds that in the past 40 years, sperm levels in Western countries have plummeted by 50%. She’s also documented changes in the sexual development of men and women. 

And the culprit? Endocrine Disruptors.

The Root Cause: Endocrine Disruptors

First, what are endocrine disruptors? They are toxins, toxicants, and chemicals in our environment that interfere with hormone activity. 

They’re everywhere. Used in food production, in food containers, plastics, in agriculture, in our personal care products, and even in our drinking water! Endocrine disruptors are literally everywhere, and it’s getting worse. Here are a few of the main ones that we know about and how they affect testosterone. 


Atrazine is a weed killer that’s used on our food crops like wheat and corn. It’s one of the most widely used herbicides in the US.

And it’s also one of the commonly detected pesticides in US drinking water.

In one well-cited study, researchers at the University of California, Berkeley found that exposure to Atrazine—even at very low levels—causes masculinization and even feminization of male fish, amphibians, and reptiles. In one case, it caused the complete feminization of adult male frogs

Meaning male frogs became female frogs that actually laid eggs and reproduced! This is powerful evidence that Atrazine is a powerful endocrine disruptor and could easily contribute to hormonal abnormalities in men.

BPA (Bisphenol A)

BPA is a synthetic compound commonly used to create plastics. It’s found in a variety of consumer goods including plastic water bottles, food packaging containers, baby bottles, sports equipment, and even CDs. 

BPA turns out to be a xenoestrogen, mimicking estrogen in the body. It’s a carcinogen, having been linked to breast cancer and it appears to lead to changes in brain development among other health risks

BPA has also been shown to dramatically lower testosterone production.

While the FDA maintains that it’s safe at low levels, the problem is that we don’t really know what effect it has on our bodies or hormones. And it’s everywhere. While efforts to remove it from many products have been successful, the result may not have been better chemicals—just different ones.

Birth Control

How Environmental Toxins Can Crush Your Testosterone

Isn’t birth control just for women?

Well, yes, it is intended for women. But it turns out that the molecule in birth control pills—estradiol—doesn’t break down very easily. It’s excreted out of women’s bodies via urine, where it enters our water supply. 

And while our water treatment systems are very good at getting rid of the bacteria and other harmful things in the drinking water, they aren’t good at removing this particular endocrine disruptor. It’s detectable in the water supply in many cities. 

What effect does it have? It’s clear that it’s disrupting our hormone levels. And we know that it can have impacts on fertility that don’t just affect one generation. In one animal study, it affected fertility for up to three generations

(As an aside, never throw old prescription medications—birth control or otherwise—down the drain or in the toilet. Throw them in the trash).


Phthalates are chemicals that are used to make plastics soft and flexible. They are present in everything from perfumes and colognes to soaps, shampoos, and deodorants, vinyl flooring, and raincoats, to your garden hose to lipstick.

The problem with phthalates is that they get into the water we drink. And when they’re in skin creams or plastics, we can absorb them through our skin. 

And they have a dramatic effect on testosterone. Several research studies have found evidence that phthalate exposure can reduce testosterone and interfere with testicular function

Not good. 

What You Can Do

These are just a few of the chemicals and toxicants that we’re exposed to on a daily basis. We are literally bathing in a soup of endocrine disruption!

And it’s contributing to the testosterone pandemic we’re experiencing. I’m not exaggerating when I say that this is a public health crisis. 

So what can we do?

It’s easy to say, “Well, plastic is everywhere, so there’s nothing I can do.”

But actually, there is quite a bit you can do to minimize your exposure. There are choices you can make. And when you make the choice to minimize your risk, you’re also making the choice to give yourself a much better shot at healthy testosterone levels. 

Here are the steps everyone can take to mitigate their exposure to these environmental toxins.

Be Careful What You Eat

man eating healthy | Gapin Institute

Because endocrine disruptors are often used in pesticides, herbicides, and fungicides, they are used heavily in agriculture and can make their way into your food. To avoid them, try to:

  • Eat grass-fed meats
  • Eat organic foods when possible
  • Avoid milk, if possible. If you must have milk, choose only organic. Try almond milk instead!
  • Avoid soy, which is highly processed here in the US, and loaded with phytoestrogens
  • Eliminate highly processed foods
  • Cook at home when possible so you know exactly what’s being used

Eating a clean diet doesn’t have to be complicated. Choose real foods: fruits, vegetables, and clean meats. Avoid eating highly processed foods or food with ingredients that you can’t pronounce. 

Be Careful What You Drink

Water is essential for health. But even though the US has relatively good water systems endocrine disruptors can make it into your tap water and they’re also often found in bottled water.

I recommend:

  • Avoiding plastic water bottles 
  • Opting for glass or stainless steel drinking containers
  • Getting a charcoal water filter (charcoal helps remove these chemicals)

When it comes to coffee:

  • Avoiding plastic coffee cups
  • Avoiding single-use coffees like K cups and Nespresso pods

Be Careful with Food Packaging

Avoiding environmental toxins | Gapin Institute

There’s often a ton of plastic in food packaging. 

  • Avoid buying foods wrapped or packaged in plastic
  • Avoid using plastic wrap or plastic Tupperware to store food
  • Never heat up your food in a plastic food container. Heat dramatically increases the release of chemicals from plastics into your food
  • Store food in glass or metal containers

Be Careful What You Put on Your Body

Unfortunately, endocrine-disrupting chemicals are in lots of the cosmetics and personal care items that we use. It’s hard to avoid them if you don’t know what to look for. But there are some ways to make better choices. 

I recommend three apps that I use to find products that are less hormonally risky:

To use them, just scan the barcode of the product you’re considering and it will tell you if there are any serious concerns. 

Understand Your Genes

Above are strategies that everyone can use, regardless of your own personal genetic make-up. 

But precision medicine allows us to understand how our body responds to toxicity and exposure to these chemicals. We’re able to figure out how well we detox, whether we’re at risk for inflammation, and more. 

Understanding exactly how our genes work helps to protect us at an epigenetic level.

So working with a precision medicine expert can help you understand your genetic blueprint and understand exactly what steps you can take to optimize your detoxification and overall health.

Joe Raised His Testosterone Naturally, and so Can You

Fortunately, Joe’s story ended well. 

After a thorough analysis of his lifestyle and habits, we created a personalized health plan that helped him increase his testosterone levels and optimize all of his other hormones as well, including thyroid, DHEA, Vitamin D, and melatonin.

Leveraging his genetics helped him know what to eat, what not to eat, what micronutrient support he needed, and how to upregulate his detox pathways so he could get rid of toxins more quickly. 

We reduced his exposure to endocrine disruptors, made sure that he was eating well, and got him a good water filter. We helped him choose personal care products that were toxin-free.

And we covered the basics – we focused on optimizing his sleep, managing his stress, and developing a fitness program that worked with his lifestyle..

In the end, Joe’s performance improved and he saw a huge enhancement in his quality of life.

Don’t Settle for Something That’s Not Working

Joe was in a bad place. But he got help, he put in the work, and he got better. 

I’m passionate about men’s health because I know how it ultimately affects mens’ lives. I see how often guys struggle with a poor quality of life. Whether it’s weight gain, erectile dysfunction, poor energy, fatigue, guys simply put up with problems.

And our environment contributes to these problems. 

But we can still solve them. 

If you think you might have low testosterone, book a call with me today. I can help you boost your testosterone and live a healthy, fulfilling life. 

Schedule a consultation to take control of your testosterone!

In Male 2.0™, Dr. Tracy Gapin has turned everything we once thought we knew about men’s health and performance upside down. The old model of how to be “a man” is broken. A man who works himself to death.  Unfortunately, a man who tries to NOT get sick but isn’t really healthy either.  And a man who takes a pill for every ill but is never really cured. That was Male 1.0. Now, imagine being THE MAN ─ owning your performance in the bedroom, the weight room, and the boardroom. Living a fully optimized life. Becoming limitless. This is Male 2.0!

Tracy Gapin, MD, FACS  is a board-certified Urologist,  world-renowned Men’s Health & Performance Expert, Author, and Professional Speaker. Using state-of-the-art biometric monitoring, nutrition, and lifestyle intervention, Dr. Gapin coaches Fortune 500 executives and evolutionary leaders of business, sports medicine, and high performance. He specializes in cutting-edge precision medicine with an emphasis on epigenetics, providing men with a personalized path to optimizing health & performance.

Want more tips to optimize your health?  Listen to the latest podcasts. Click HERE



Hayes, T. B., Anderson, L. L., Beasley, V. R., De Solla, S. R., Iguchi, T., Ingraham, H., … & Willingham, E. (2011). Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes. The Journal of Steroid Biochemistry and Molecular Biology, 127(1-2), 64-73.

Hayes, T. B., Khoury, V., Narayan, A., Nazir, M., Park, A., Brown, T., … & Gallipeau, S. (2010). Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis). Proceedings of the National Academy of Sciences, 107(10), 4612-4617.

Travison, T. G., Araujo, A. B., O’Donnell, A. B., Kupelian, V., & McKinlay, J. B. (2007). A population-level decline in serum testosterone levels in American men. The Journal of Clinical Endocrinology & Metabolism, 92(1), 196-202.

Men’s Health: How BPC 157 Could Supercharge Your Body’s Healing and Health

How BPC-157 could supercharge your body's healing and health
BPC-157 helps repair tissues and helps your body recover.

I’m getting really excited about peptides.

It’s not just me: the general medical community is coming to understand—if slowly— what a small group of dedicated researchers have known for decades: peptides may be the key to aging gracefully. 

They’re promising for a few reasons. 

The first—and most important—is that they actually seem to work. Unlike many fads in the men’s health and precision medicine space, peptides are walking the talk.

The second is that they work by using your body’s own biology. Rather than introducing a harsh chemical to your system and hoping for the best, peptides are already used by your body to regulate itself. So they fit well in our body’s complex machinery.

And the third reason is that there are so many. There are thousands of peptides known to science, and only a handful have been truly and properly studied. Different peptides have very different effects. There’s a ton of promise. 

This article is about one peptide in particular that is widely used in athletics and by biohackers. It’s called “gastric pentadecapeptide body protection compound” but is more commonly known as BPC-157—“body protection compound”. 

While we’re still learning more about it, the evidence indicates it could be used to greatly boost recovery from injuries, help heal stomach ulcers, and have a number of other protective effects. 

What is BPC-157?

BPC is a peptide, which means it’s a short chain of amino acids—the substances that make up proteins. It’s a pentadecapeptide, which means that it’s made up of 15 amino acids held together by peptide bonds.

BPC is considered a “synthetic” peptide because this particular substance is created synthetically in a lab. But it was derived from a protein that is found in the human body. BPC, chemically, looks like a smaller part of that natural protein.

Peptides are often used by our bodies as chemical messengers. They help regulate a number of different functions and get the body performing at its best. 

Because they’re naturally used by our body, supplementing peptides has become an effective therapeutic technique. The peptide therapies that exist can be used for a number of beneficial uses including to boost the immune system, to help with weight loss and burning fat, and even to reduce inflammation.

What does BPC-157 do?

Well, it appears that it has a number of potential benefits, especially when it comes to helping your body heal and repair after an injury.

BPC-157 speeds up tissue repair

BPC-157 has been found to speed up the healing of lean body tissues like muscle, ligaments, and tendons.

Some of the promising studies on BPC-157 have found that they may be effective in speeding up the repair of ligaments, tendons, muscle tissue, and even the skin. 

For example, in one study, BPC-157 consistently healed damaged ligaments in rats much quicker than if it was not present. The healing was effective, too: it preserved the function and biomechanics of the joint. In another study, BPC-157 was found to kickstart the production of collagen. Collagen helps skin look elastic, and is also essential to joint health, as well as hair and nails. In a further study, BPC sped up bone repair. 

Those results seem to hold across studies. In a 2019 review, researchers found that BPC-157 was consistently able to repair soft tissue injuries across all the research that they reviewed. They noted,

“All of the studies to date that have tested BPC 157 as a treatment therapy have demonstrated extremely positive healing effects for various injury types in a number of soft tissues.”

I should note an important caveat to this research: most of the studies that have been done on this peptide have been done on animals—usually rats. That’s normal:  animal studies are used to get a sense of what a compound does and to get a sense of its safety. That’s partly so that humans are not put at risk, but it’s also because research on animals is much less expensive to do. Then researchers move to humans so they are confident that it could work and when they are willing to invest in much more expensive research.

Since rats have a lot in common with humans, including how our muscles and lean tissues work, the research results for BPC-157 are quite promising. 

But of course, since most of the research hasn’t been conducted on humans, we need to be cautious about making too much of these findings.

BPC-157 helps heal your gut

One of the focuses of BPC-157 research is on its role in contributing to gut health. This is the focus mostly because BPC-157 was originally derived from a protein that is found in the gut. 

Research now suggests that it can have a powerful effect on protecting and healing damaged digestive tissue: it’s been found to inhibit the formation of lesions in the esophagus, stomach, and duodenum. This is especially true of the oral form of BPC-157, which is especially good for the gut. 

BPC-157 route of administration

BPC-157 can be taken orally or it can be injected subcutaneously (just beneath the skin).  It appears to have the most powerful effect on gut health when taken orally, whereas subcutaneous injections are better for reducing systemic inflammation and aiding with tissue repair. BPC-157 can be injected subcutaneously in the lower abdomen, or for better effect in specific joints or muscles, can be injected near the site of concern (for example, you might inject it near the elbow if you wanted to heal an elbow injury). 

BPC-157 reduces harmful side effects of other medications

It can also help protect the gut from other chemicals.

The magic of modern medicine has given us a number of important pharmacological interventions (medications) for a wide range of diseases and medical issues. These are often essential.

But they also may have some harmful side effects. 

For example, haloperidol is a commonly used medication for treating the symptoms of some psychological illnesses like mania and schizophrenia. It’s a very useful drug, but it can also be quite rough on the body. One side effect of haloperidol is that it causes stomach lesions. Stomach lesions are also a side effect of some chemotherapy medications that are used to treat cancer.  

BPC-157 seems to be able to counteract these in many cases, preventing these lesions. That suggests it could be useful as a complementary therapy when these other medications are prescribed.

BCP-157 enhances blood flow

Doctors and scientists suspect that one of the ways BPC works to repair tissue is by increasing blood flow to injuries. After all, blood brings the body what it needs to repair itself: oxygen, nutrients, antibodies, and so on. 

And BPC-157 seems to increase blood flow. There appear to be two ways that it does so. 

The first is by upregulating the expression of growth factor early growth response gene-1 (also called EGR-1). This gene is involved in increasing the amount of blood that flows to wounds.

The second way it does this is by actually increasing the number of blood vessels. The fancy medical terms are angiogenesis (the creation of arteries) and vasculogenesis (the creation of veins). BPC-157 seems to activate vascular endothelial growth factor receptors, which are involved in increasing the number of blood vessels and repairing them. 

This insight comes from in vitro studies, which means studies done on cells isolated outside of the body (imagine scientists looking under a microscope at a petri dish). So, again, we have to be careful not to make too much of these results, since we’re investigating the effects of BPC-157 outside the body.

Still, these results are exciting because they provide a possible explanation for why we consistently see BPC-157 improving the healing and repair of tissues. 

BPC-157 has anti-inflammatory properties

Some studies have found the BPC-157 is an anti-inflammatory. It was found to significantly decrease inflammation in patients with ulcerative colitis, which is a kind of bowel disease. 

Researchers were especially optimistic about the use of BPC-157 as a treatment for inflammation because it didn’t show the same kind of side effects that other commonly prescribed anti-inflammatories have. 

What’s more, BPC-157 seems to be useful in treating both acute and chronic inflammation

BPC-157 seems to be neuroprotective

plastic brain and central nervous system model
BPC may help fight against diseases of the central nervous system and brain.

If that’s not enough, BPC could be a salve for various kinds of traumatic brain injuries. Researchers found that it has neuroprotective effects: it protects somatosensory neurons, it appears to promote peripheral nerve regeneration, and it seems to slow or even reverse the course of traumatic brain injuries from progressing. 

All those effects have led researchers to conclude that BPC 157 could serve as a new soldier in the battle against disorders of the nervous system. 

What about BPC side effects?

It’s important to make it clear that the research on BPC in humans is limited. 

BPC has been found to be safe in clinical trials conducted in several countries, with no toxicity reported. Those results are consistent with the results from the animal studies conducted to date: there haven’t been any instances of toxicity reported. 

But because of the lack of research on side effects, there is still much that we don’t know. That’s why all peptides should be carefully administered under the guidance of a clinical research trial or a qualified physician. Ideally, you’ll want to ensure that you have a doctor who understands the promise and any risks associated with peptide therapy so that you can get well-informed advice. 

Peptides can be part of a systems health approach

Our bodies are complex and massively interrelated. 

How you eat, how you sleep, whether you’re stressed, and your sexual health all are influenced by, and in turn influence, each other. You need all those things to be in place to thrive. You can’t just take a peptide and suddenly feel young and energetic again. 

But peptides can be a part of a systems-based approach to health, just like hormone therapy, a weight loss program, and other forms of lifestyle medicine. BPC-157, in particular, is promising as a way to help repair injured tissues, reduce inflammation, and generally help your body heal itself. It may be a form of peptide therapy that’s appropriate for you.

Remember, always consult a qualified physician before starting a peptide regimen. Most physicians aren’t well-versed in the promising effects of peptide therapies, but some are. Look for a doctor you can trust that understands the complexity of the body and can help you optimize your health and your life. 

BPS-157 might just be a crucial part of that.

 man looking at sunset on mountain, BPC-157 peptide therapy for health
Peptide therapy could be a useful addition to your health regimen. Ask about whether it’s right for you.

Schedule a consultation to learn how peptides can help YOU.

Ready to take the next steps?

Download the Blueprint

Schedule a Call


In Male 2.0™, Dr. Tracy Gapin has turned everything we once thought we knew about men’s health and performance upside down. The old model of how to be “a man” is broken. A man who works himself to death.  Unfortunately, a man who tries to NOT get sick but isn’t really healthy either.  And a man who takes a pill for every ill but is never really cured. That was Male 1.0. Now, imagine being THE MAN ─ owning your performance in the bedroom, the weight room, and the boardroom. Living a fully optimized life. Becoming limitless. This is Male 2.0!

Tracy Gapin, MD, FACS  is a board-certified Urologist,  world renowned Men’s Health & Performance Expert, Author, and Professional Speaker. Using state-of-the-art biometric monitoring, nutrition and lifestyle intervention, Dr. Gapin coaches Fortune 500 executives and evolutionary leaders of business, sports medicine, and high performance. He specializes in cutting-edge precision medicine with an emphasis on epigenetics, providing men with a personalized path to optimizing health & performance.

Want more tips to optimize your health?  Listen to the latest podcasts. Click HERE


Cerovecki, T., Bojanic, I., Brcic, L., Radic, B., Vukoja, I., Seiwerth, S., & Sikiric, P. (2010). Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat. Journal of orthopaedic research, 28(9), 1155-1161.

Gwyer, D., Wragg, N. M., & Wilson, S. L. (2019). Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell and tissue research, 377(2), 153-159.

Sikiric, P. S., Seiwerth, S., Rucman, R., Turkovic, B., Rokotov, D. S., Brcic, L., … & Sebecic, B. (2012). Effect of Pentadecapeptide BPC 157 on Gastrointestinal Tract. In Filaretova L. P., &  Takeuchi, K. (Eds.), Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract (Vol. 30, pp. 191-201). Karger Publishers.

Inflammation Makes You Gain Weight. Peptide Therapy Can Help You Lose Weight.

Weight loss is one of the most common health concerns among my clients.

Men struggle with weight loss even though they do all the right things: they go to the gym regularly, they eat a clean diet, they take what they think are the right supplements… but something just isn’t right. 

Losing weight seems like it should be easy if you’ve straightened out your diet and exercise… So, why is it so hard to lose that stubborn fat?

First off, the body is complex.There are a ton of factors beyond diet and exercise that matter for losing weight. Of course, sleep is really important, your hormones and testosterone matter, and stress plays a huge factor. Your microbiome and gut health almost certainly play a role, too. 

And, of course, your genes matter. Not just your actual genetic makeup, but also epigeneticswhich genes are turned on or off at a given time. 

In order to understand weight loss, and men’s health in general, we have to think about the body as a sophisticated system. If you want to lose weight, get more energy, and feel younger, there’s a constellation of factors that matter.

And here’s a big one that people often miss: inflammation. 

In this article, I want to explain the connection between your body’s inflammatory response and the difficulty you may have shedding those extra pounds. And then I’ll tell you how you can address your inflammation with targeted peptides to help you finally lose weight. 

What is inflammation?

Inflammation is your body’s general immune response. There are two main types that we’re concerned with:

  • Acute inflammation is a localized response. It’s what you get when you sprain your ankle and it swells up, gets red, and gets warm. Or when you get an infected cut. Acute inflammation is your body sending in the “good guys” to repair tissue or get rid of toxins. 
  • Chronic inflammation is a longer term, generalized response. It happens when your body’s own white blood cells stick around longer than they need to and start attacking your own body. It’s a deep-rooted, systemic problem. 

Chronic inflammation can have serious health consequences, including increased risk of cardiovascular diseases, cancer, Alzheimer’s, prostate disorders, and more.

But in addition to all those severe health issues, inflammation can also just affect how we feel day to day. It could be what’s sapping your energy and making you feel lethargic.

And, most central to this article, chronic inflammation can make it hard for you to lose weight. 

What are the signs and symptoms of chronic inflammation?

How do you know if you have chronic inflammation? It can be difficult to know, but some of the symptoms include:

  • Being overweight or obese
  • Heartburn, nausea, gas, and other gut problems
  • Fatigue and chronic feelings of being tired
  • Difficulty sleeping
  • Prostate problems
  • Stress
  • Mental fog or emotional instability
  • High cholesterol or blood pressure
  • Pains or weakness in the muscles that don’t have a clear cause

Chronic inflammation often simply looks like a general feeling of being unwell without a clear cause. 

What causes inflammation?

Chronic inflammation is caused by the regular suspects that are related to poor health: a poor diet that’s high in sugars, saturated fats, and trans fats; obesity; stress; and smoking. It can also be caused by periodontal disease, an imbalance of hormones, and inadequate sleep. 

How does inflammation contribute to weight gain?

Inflammation and weight gain go together. 

First, the research suggests that fatty tissue can trigger inflammation. One study found that adipose tissue actually stimulates your body to release inflammatory mediators like interleukin 6 and tumor necrosis factor α. Other research has suggested that overeating can lead to inflammation. So being overweight can contribute to inflammation.

But it works the other way, too: inflammation can cause you to gain weight—and keep it. One way inflammation does that is by changing how we absorb and use the food we eat. Inflammation can actually affect our gut health: it can influence the bacteria that make up our microbiome and even affect how nutrients and energy are extracted from the food we eat. 

For another thing, inflammation may cause us to feel more hungry and to choose to eat foods that are worse for us. And to make matters worse, it also may be one cause of insulin resistance, which makes it more difficult to turn blood glucose into energy.

So being overweight can contribute to chronic inflammation. And inflammation contributes to weight gain. It can turn into a vicious cycle. 

The good news is that you can reverse it: losing weight helps reduce inflammation… and reducing inflammation will help you lose weight. 

How to reduce inflammation

Adopting a generally healthy lifestyle can help reduce inflammation. That means eating a balanced, nutrient-rich diet; avoiding processed foods, sugary, and fried foods; exercising enough; managing your stress; sleeping enough; and quitting smoking. Those are the basics. 

But even after doing all those things, you may find that you need a bit of a boost to lower your inflammation. 

That’s where the strategic use of peptide therapies comes in. 

Peptides can help disrupt chronic inflammation and help you lose weight

The scientific and medical community is only really just becoming aware of how important peptides can be in helping people age well.

Peptides are small chains of amino acids—like proteins, but shorter. 

What do peptides do? Well, there are now thousands of different peptides known to scientists, and there’s a huge variety in the effect that they have. But they often work as chemical signals, helping our body to regulate itself. 

For instance, some boost your immune system; others, like BPC-157, help your body repair tissues; others, like tesamorelin, stimulate growth hormone and help you put on muscle; and yet others, like amlexanox, can reduce inflammation and help burn fat. 

If peptides are made naturally, how does peptide therapy help?

Our body naturally makes peptides, but production of these essential chemical regulators tend to decrease with age. That’s one of the reasons that our body stops functioning properly as we get older.

Peptide therapies and supplements help restore key peptides back to the level you had in your early 20s. And they can bring back the benefits of a younger body: faster healing, faster metabolism, and improved weight loss, among others. 

Amlexanox and weight loss

Amlexanox is one peptide that plays a role in reducing inflammation. That’s why it’s one of the best peptides for weight loss and fat loss

Amlexanox has a powerful anti-inflammatory effect. Traditionally, it’s actually been used to treat stomach ulcers because it reduces healing time and pain. It works in several ways, including by inhibiting the release of histamine and leukotrienes.

But it also has been found to promote weight loss. 

Some research has found that Amlexanox inhibits the TBK1 enzyme, which may enhance the body’s ability to burn fat. It also seems to inhibit IKK-ε, which is an inflammatory mediator. By inhibiting it, Amlexanox improves the metabolism of glucose and improves energy. 

Finally—and this brings us back to epigenetics—Amlexanox seems to “turn off” the expression of “fat genes”

While the research on Amlexanox is still in its infancy, the existing literature does suggest that Amlexanox can have some powerful effects: fighting weight loss and reducing inflammation so you feel your best.

Amlexanox plus TTA give fat a one-two punch

When Amlexanox is used to combat weight gain, it’s usually combined with Tetradecylthioacetic Acid, or TTA. 

TTA is a fatty acid that’s given as a nutritional supplement. When you hear “fatty acid”, you might think that’s a bad thing. But don’t worry—it doesn’t get used by the body for fuel. Instead, it actually helps regulate how the body stores fat.

TTA helps decrease hunger and upregulate metabolism of fat. That means it helps you burn through fat quicker. 

Together, Amlexanox and TTA are an effective fat-fighting duo. 

The men’s health takeaway: Target inflammation to lose weight

The body works together in one big system. That’s why it’s not enough for many people to use a simple equation like, “calories in, calories out”. If it were, weight-loss diets would work and it would be easier to slim down.

To really lose weight and feel healthy, you need a systems approach.

It turns out that a very significant contributor to gaining weight from fat is inflammation. That means that if you’re trying to lose weight, you want to do what you can to minimize inflammation. Some things you can do yourself, like eating well and getting enough sleep. 


But you might also want to power-up your own efforts with a tailor-made plan from an expert in peptide therapies. A personalized medicine plan that includes the strategic use of peptides like Amlexanox may be exactly what you need to get your body working at its best.  

Schedule a consultation to learn how  peptides can help you lose weight. 

Ready to take the next steps?

Download the Blueprint

Schedule a Call


In Male 2.0™, Dr. Tracy Gapin has turned everything we once thought we knew about men’s health and performance upside down. The old model of how to be “a man” is broken. A man who works himself to death.  Unfortunately, a man who tries to NOT get sick but isn’t really healthy either.  And a man who takes a pill for every ill but is never really cured. That was Male 1.0. Now, imagine being THE MAN ─ owning your performance in the bedroom, the weight room, and the boardroom. Living a fully optimized life. Becoming limitless. This is Male 2.0!

Tracy Gapin, MD, FACS  is a board-certified Urologist,  world renowned Men’s Health & Performance Expert, Author, and Professional Speaker. Using state-of-the-art biometric monitoring, nutrition and lifestyle intervention, Dr. Gapin coaches Fortune 500 executives and evolutionary leaders of business, sports medicine, and high performance. He specializes in cutting-edge precision medicine with an emphasis on epigenetics, providing men with a personalized path to optimizing health & performance.

Want more tips to optimize your health?  Listen to the latest podcasts. Click HERE

What is Nrf2? Here’s Everything You Need to Know About the Secret to Aging Well

What is Nrf2? Healthy man photo | Gapin Institute


Feel like you’re just not operating at the level you used to?

People tell us that that happens with age—that our bodies start to break down.

But the most recent science is actually calling into question the inevitability of the symptoms of aging. New research in microbiology, chemistry, and genomics is showing us that those uncomfortable symptoms of aging might not be locked in.

This is where “biohacking” comes from: it’s the idea that you can give your body exactly what it needs to properly repair and rejuvenate itself. The result? Optimized health and performance.

Nrf2 is one of the most exciting discoveries in this area and holds some real promise as an anti-aging agent and as a support for your long-term health. In this article, I’ll explain what it is, what it does, and why it matters for your aging. 

What is Nrf2?

Nrf2, short for “nuclear factor erythroid 2-related factor 2”, is a protein that is found in your cells. It is a type of protein called a “transcription factor”, which means that it is involved in gene expression—activating and deactivating parts of a genetic sequence. 

Which genes does Nrf2 affect? It regulates the expression of antioxidant proteins and enzymes, increasing their production to help your body fight off molecules that attack your cells. 

Nrf2 has been found to be an important part of your body’s system of regulating metabolism, inflammation, and immune responses

What’s special about Nrf2?

 Nrf2 is a big deal because it could be the key to aging gracefully and healthily.

When you’re young, your body is good at balancing all the needs of your body at the cellular level. But as you age, these important chemical signallers decline. You begin to produce less of the substances that you need to properly regulate your body.

That means that there are fewer of the peptides, proteins, hormones, and enzymes that help your body repair and rejuvenate. Things start to break down.

The result is that your body gets slower at repairing itself. That’s why you feel tired more often, your body takes longer to recover from exercise, and your skin begins to see signs of aging. You might also notice issues with your sleep or even erectile dysfunction

Oxidative stress contributes to symptoms of aging

At the cellular level, what’s happening is that free radicals are constantly bombarding your cells. The damage caused by these attacks causes your cells to go into a state called oxidative stress, and stop functioning properly. 

When you’re young, your body can easily fight free radicals back. But as you get older, your body can’t do this as effectively. That’s when symptoms of aging start getting worse.

Antioxidants fight free radicals and reduce oxidative stress

You’ve probably heard of the health benefits of antioxidants. Some foods are high in antioxidants and that’s why health professionals sometimes encourage you to include them in your diet. 

Antioxidants  help neutralize free radicals and minimize the damage that they cause. That helps reduce the symptoms of aging. 

But antioxidants aren’t very efficient. One antioxidant molecule neutralizes only one free radical. With more and more free radicals, we need more and more antioxidants. At some point, the antioxidants can’t keep up. 

What does Nrf2 do?

Nrf2 provides a powerful solution to overcome free radicals. It’s known as the “master regulator” of our body’s antioxidant response.

When Nrf2 is activated, it enters the nucleus and turns on several hundred genes, known collectively as “survival genes.” This, in turn, initiates the production of several of your body’s own powerful enzymes that fight free radicals. These enzymes include catalase, glutathione, and superoxide dismutase (SOD)

These enzymes are much more effective than antioxidants at getting rid of free radicals—they can neutralize over 1 million free radicals a second. What that means is that your body can clean itself out quickly and fewer of your cells get into a state of oxidative stress. 

Ultimately, that means you feel fewer symptoms of aging: better energy, better sleep, and even a better sex life

How do I get Nrf2?

Great, Nrf2 can support my health. How do I get it?

You actually don’t need to get Nrf2—it’s already right there in your cells. It comes pre-installed.

The problem is that it’s not activated. It’s a bit like an engine: it just sits in your cells not doing anything until it’s turned on. That’s what Nrf2 activation therapies do: they get into your cells to turn on Nrf2 so that it can enter the nucleus and work its magic. 

Some foods have been shown to activate Nrf2 and the Nrf2 pathway. These have been supported by studies in nutrigenomics—the study of how food influences gene expression and cellular function. 

Some Nrf2-activating foods include:

  • Dark chocolate 

  • Legumes, like lentils, beans, and peas

  • Vegetables, especially dark leafy greens like spinach and cruciferous vegetables like broccoli, cauliflower, and bok choy

  • Spices, especially ginger, turmeric, cinnamon, cloves, and yellow mustard

  • Herbs, like oregano

  • Red wine

  • Tea, especially green and white teas

What about Nrf2 supplements? Do they work?

In addition to activating Nrf2 through the diet, there are now supplements that activate Nrf2 and significantly reduce oxidative stress. 

These have been extremely well-researched by the scientific community and some of the supplements have very strong evidence supporting their use. 

Protandim®, for example, is a supplement designed to activate Nrf2. There have been numerous studies that demonstrate that it improves your body’s antioxidant response capacity. Peer-reviewed, human clinical studies show that it reduces cellular stress in humans by an average of 40 percent in 30 days. Research even suggests that it could be effective in preventing age-related diseases like:

The takeaway for your health: Nrf2 activators could help you feel younger. A men’s health secret.

We often think that there isn’t much we can do about the declines in our bodies that come with age. But science is showing us that that’s not necessarily the case. 

There actually may be ways that we can give our body what it needs to better regulate, repair, and rejuvenate itself.

Nrf2 appears to be one of those ways. Activating the Nrf2 pathway could be a relatively simple—but powerful—way to help you feel younger again. 

It might be as easy as making good diet choices or taking a supplement. 

Schedule a consultation to learn how to personalized health advice so you can live your life to the fullest. 

Ready to take the next steps?

Download the Blueprint

Schedule a Call


In Male 2.0™, Dr. Tracy Gapin has turned everything we once thought we knew about men’s health and performance upside down. The old model of how to be “a man” is broken. A man who works himself to death.  Unfortunately, a man who tries to NOT get sick but isn’t really healthy either.  And a man who takes a pill for every ill but is never really cured. That was Male 1.0. Now, imagine being THE MAN ─ owning your performance in the bedroom, the weight room, and the boardroom. Living a fully optimized life. Becoming limitless. This is Male 2.0!

Tracy Gapin, MD, FACS  is a board-certified Urologist,  world renowned Men’s Health & Performance Expert, Author, and Professional Speaker. Using state-of-the-art biometric monitoring, nutrition and lifestyle intervention, Dr. Gapin coaches Fortune 500 executives and evolutionary leaders of business, sports medicine, and high performance. He specializes in cutting-edge precision medicine with an emphasis on epigenetics, providing men with a personalized path to optimizing health & performance.

Want more tips to optimize your health?  Listen to the latest podcasts. Click HERE


Houghton, C. A., Fassett, R. G., & Coombes, J. S. (2016). Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician’s expectation be matched by the reality?. Oxidative Medicine and Cellular Longevity, 2016.

Hybertson, B. M., Gao, B., Bose, S. K., & McCord, J. M. (2011). Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Molecular Aspects of Medicine, 32(4-6), 234-246.

Lim, J. L., der Pol, V., Susanne, M. A., Baron, W., McCord, J. M., De Vries, H. E., & Van Horssen, J. (2016). Protandim protects oligodendrocytes against an oxidative insult. Antioxidants, 5(3), 30.

50 Leaders Transforming Health & The Future of Medicine

Finding the best resources for upgrading your health can be a difficult task.  My goal is to help every man on the planet optimize his performance, testosterone, health, and life.   My passion is to help men thrive so they can be better fathers, husbands, leaders, and role models for future generations. 

To that end, I’ve launched the Male 2.0 Movement to tackle the testosterone epidemic and men’s health crisis we are experiencing. My goal is to help men overcome issues such as obesity, cognitive decline, metabolic syndrome, hormone imbalance, and aging. I’ve joined forces with other experts in the field to transform men’s lives and create long-term positive change for generations to come.

I want you to have access to everything you need to be the best man you can be, so I’ve gathered a list of the top 50 influencers who are optimizing men’s health.  These are thought leaders in the human optimization arena focused on transforming men’s lives. Listed alphabetically but not in any other order, each person addresses different challenges and has unique methodologies based in the latest research and science.  For those of you new to my blog, I’m also including how I’m contributing to this movement through my practice and unique Male 2.0 Method. 

About Tracy Gapin, MD

Dr. Tracy Gapin

Tracy Gapin, MD is a medical doctor and practicing surgeon tackling the Men’s health crisis and Testosterone epidemic. He is focused on helping men not just improve testosterone levels, but also upgrade energy level, focus, vitality, and performance, and actually reverse aging. In fact, he clearly believes men’s health is not just about testosterone optimization, but human optimization. 

His Male 2.0 method approaches health using epigenetic science and four key factors:  Mindset, Aging, Lifestyle, and Environment. Many men are challenged by symptoms caused from low testosterone.  However, you’ll have limited results if you are addressing testosterone without taking a more comprehensive approach, integrating solutions for other aspects of health as well, including sleep, mindset, nutrition, fitness, and detoxification. 

Using cutting-edge age management protocols, Dr. Gapin coaches Fortune 500 executives, entrepreneurs, and evolutionary leaders of business and high performance. He incorporates epigenetic coaching, hormone optimization, peptide therapy, state-of-the-art biometric monitoring, and nutrition and lifestyle intervention to provide men a personalized path to optimizing health & performance.

Hear more on Dr. Gapin’s men’s health podcast coming soon — Beyond Testosterone.

50 Health Optimization Leaders Transforming Men’s Health

Boomer Anderson is the founder of Decoding SuperHuman and a leader in genetic technology.  He thought he was in good health at 30— already using biohacking, working out and eating clean.  But then he was diagnosed with heart disease.  He decided to use his genetic code and data to optimize his health and performance— and now helps others achieve superhuman results.  The Decoding Superhuman methodology provides an individualized approach to performance backed by science and data. It utilizes behavior change, performance analysis, and data technology to help clients achieve and sustain a high-performance life.  You can also check out his podcast in which he discusses a variety of topics such as sleep, environment, nutrition and behavior.

Dr. Peter Attia

Dr. Peter Attia is the founder of Attia Medical, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity. He applies nutritional biochemistry, exercise & sleep physiology, pharmacology, and four-system endocrinology to delay the onset of chronic disease, while simultaneously improving quality of life.   A trained physician whose career started in general and oncological surgery, he has shifted his focus to the applied science of longevity, the extension of human life and well-being. Peter is the co-founder and Chief Medical Officer of the fasting app Zero and hosts a popular weekly podcast, The Drive, with topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.

Dave Asprey

Dave Asprey is Bulletproof founder, CEO and Father of Biohacking whose “aha moment” happened on a trek in Tibet when he experienced the rejuvenation of yak butter tea.  Bulletproof is built on the science that helped Dave lose 100 pounds and hack his own biology to become a stronger, healthier person. Bulletproof products are backed by the ancient knowledge from Ayurvedic and Chinese medicine that transformed Dave’s life.  The Bulletproof line started with a focus on coffee but now offers a wide range of research-backed supplements and nutrition.

Dr. Axe

Dr. Axe is a certified doctor of natural medicine, doctor of chiropractic and clinical nutritionist with a passion to help people with their health. He operates one of the world’s largest natural health websites,  Dr. Axe is the best-selling author of the groundbreaking heath book Eat Dirt and Keto Diet. His latest book, The Collagen Diet, is now available in stores. He worked with U.S. athletes at the 2012 Olympic games and has been featured on The Dr. Oz Show and Today Show

Dr. Jeffrey S. Bland

Dr. Jeffrey S. Bland is known as the “father of functional medicine.” Over the past thirty-five years, Dr. Bland has traveled more than six million miles, teaching more than a hundred thousand health-care practitioners in the United States, Canada, and more than forty other countries about functional medicine. He has been a university biochemistry professor, a research director at the Linus Pauling Institute of Science and Medicine, the co-founder of the Institute for Functional Medicine in 1991, and the founder/president of the Personalized Lifestyle Medicine Institute. He has authored more than one hundred scientific publications and ten books for health professionals and consumers.

Ben Brown

Ben Brown, is the owner of BSL Nutrition, an online nutrition & fitness consulting business specializing in individualized nutrition, lifestyle, and strength training programs for highly driven busy men. He has masters degrees in Clinical Nutrition and Exercise physiology, but it was his own personal journey with chronic fatigue and Epstein-Barr Virus that inspired him to support others in removing common immune suppressing habits.  He works with both individuals and businesses, as well as consulting professional sports teams, including the Arizona Diamondbacks and Golden State Warriors. Although these are cool opportunities, he finds it more rewarding to work with regular day “Joes”: those who are struggling to find the balance between business and family to optimize their health.

Jay Campbell

Jay Campbell is the founder of the TOT Revolution site and podcast, a leading resource in men’s health with a focus on hormones and optimizing health.  When Jay was 29, he was kicked in the testicles and has been receiving therapeutic testosterone since. Jay’s ultimate mission is to create resources for men to get the real and honest truth about using therapeutic testosterone.  He also founded as the premier online destination for patients to find the best vetted physicians in the USA. Jay has experience working with thousands of men in optimizing their nutrition and fitness.

Dr. Michael A. Dempsy

Dr. Michael A. Dempsy, is a seasoned physician with a busy general endocrinology practice, with a special emphasis on diabetes.  He has been actively involved in more than 150 diabetes related clinical trials since 2000 with research focusing on rapid and long acting insulin analogues as well as new oral or injectable glucose lowering therapies.  As your go-to resource for research and education on diabetes, he provides a unique perspective on the underlying causes, prevention, and treatment.

Dr. Geo Espinosa

Dr. Geo Espinosa is a naturopathic doctor, acupuncturist and functional medicine practitioner recognized as an authority in holistic urology and men’s health. His thriving clinical practice focuses on conditions such as prostate cancer, pelvic pain, and sexual dysfunction.  Dr. Geo is the author of the best selling prostate cancer book: Thrive, Don’t Only Survive.  Dr. Geo created XY Wellness ( as a resource offering integrative programs, supplements, and education for men living with prostate cancer.

William (Bill) Faloon

William (Bill) Faloon has been researching anti-aging since the 1960’s and compiled the 1,500 page medical reference book Disease Prevention and Treatment and his latest book is Pharmocracy.   He argues that aging is the greatest affliction of humanity and that if people had the opportunity to live longer, many of society’s problems would disappear.  Holding a controversial stand, the federal government raided his facilities twice, initiated an 11-year criminal investigation, and threw him in jail in 1991! After several lawsuits, all claims and charges were revoked.  However, with more media coverage, he has been able to spread his scientifically- supported message of optimal health to hundreds of thousands of members and subscribers of Life Extension Magazine.

Tim Ferriss

Tim Ferriss is someone most of us have heard of, but we couldn’t leave him off the list.  Tim Ferriss has been listed as one of Fast Company’s “Most Innovative Business People” and one of Fortune’s “40 under 40.” His mission is to help people hack their lives for optimal performance and health.  An author, speaker, and podcast host, Tim tests and experiments with ways to become superhuman and accelerate results in the least amount of time.  Known best for his first book, The 4-Hour Workweek, he has gone on to apply this 4 hour technology to fitness and cooking in additional books.  If you no longer want to be ruled by the belief that having a life you love requires a lot of time and effort, follow Tim Ferriss!

Dr. Tracy Gapin

Dr. Tracy Gapin is a world renowned men’s health & performance expert, professional speaker, entrepreneur, and author of Male 2.0: Cracking the Code to Limitless Health and Vitality. He has over 20 years of experience focused on providing Fortune 500 executives, business leaders, entrepreneurs, and athletes a personalized path to optimizing their health and performance. Dr. Gapin incorporates precision hormone optimization, peptide therapy, state-of-the-art biometric tracking, epigenetic coaching, and cutting-edge age management protocols to help men not just optimize their testosterone levels but transform their health and vitality and reverse aging so they can be the most amazing version of themselves. As a renowned speaker, Dr. Gapin shares his signature talk with medical audiences and men’s health organizations: A Data-Driven Personalized Approach to Optimizing Men’s Health. Founder of the Gapin Institute for Men’s Health and the Male 2.0 Method, he is creating a meaningful impact for men’s health.

Ben Greenfield

Ben Greenfield has been named one of the world’s top 100 most influential people in health and fitness, coaching the world’s top CEO’s and athletes.  A self-proclaimed science nerd, he built a brick-and-mortar fitness empire, wrote a bestselling book “Beyond Training” and now has an online blog and podcast that is top rated for his resources around biohacking, health, and fitness. As founder and CEO of Kion, Ben now creates step-by-step solutions for the world’s active, high-achievers to live a full life with optimized minds and bodies.

Dr. Jeffrey Gladden

Dr. Jeffrey Gladden is a board certified interventional cardiologist and founder of Apex Health, Human Performance & Longevity Optimization. Though interventional cardiology had been his calling and livelihood for the 25 years, Dr. Gladden knew he needed a change for the sake of his own health and that of his family when, in his mid-fifties, his health took a turn for the worse. When modern medicine couldn’t help him, he threw himself into learning everything he could about functional medicine, bio-identical hormone replacement and age management medicine. This led to diagnosing his own subclinical hypothyroidism.  With changes in diet based on genetics and gut biome data, he began to feel more youthful again. He is now committed to sharing his knowledge with others through consulting and as co-host of the podcast, “Living Beyond 120”.

David Goggins

David Goggins transformed himself from a depressed, overweight young man into a U.S. Armed Forces icon and one of the world’s top endurance athletes. The only man in history to complete elite training as a Navy SEAL, Army Ranger, and Air Force Tactical Air Controller, he went on to set records in numerous endurance events, inspiring Outside Magazine to name him “The Fittest (Real) Man in America.”  But David doesn’t care about metals and accolades, rather it is about achieving his personal best and pushing himself well past his comfort zone. For him, physical and mental suffering are a journey of self-discovery and no other experience makes him feel more clear, focused, and alive. In his book Can’t Hurt Me, he shares his astonishing life story and reveals that most of us only tap into 40% of our capabilities.  He illuminates a path that anyone can follow to push past pain, demolish fear, and reach their full potential.

Aubrey de Grey

Aubrey de Grey is an English author and biomedical gerontologist.  As the Chief Science Officer of the SENS Research Foundation and VP of New Technology Discovery at AgeX Therapeutics, his mission is to reduce death from age-related causes through regenerative medicine.  Dr. Grey has identified seven types of molecular and cellular damage and provides access to therapies that can repair this damage. He has been interviewed as an expert on anti-aging in top media outlets like 60 Minutes, The New York Times, and TED

Dr. Mickra Hamilton

Dr. Mickra Hamilton is Co-Founder and CEO of Apeiron Zoh and the Apeiron Academy.  She is also a retired Colonel and Human Performance Subject Matter Expert in the United States Air Force Reserves.  As a “Human Systems Designer,” and creative disruptor in the field of Epigenetic Human Performance Coaching, she creates a new paradigm for what is possible for human flourishing through a personalized systems-based precision approach.  Dr. Hamiltons speaks internationally on topics such as epigenetics of the human environment, performance breathing, conscious leadership, peak psychophysiological performance and stress optimization. In Apeiron’s R & D division, her current developments focus on 3-D soundscape/naturescape virtual reality programming and breath/heart/brain entrainment to  create beneficial shifts in states of consciousness.

Bill Hanks

Bill Hanks left his career in engineering to open Cryo Recovery (now Huemn) in Houston,Texas after a personal health transformation using cryotherapy to reduce an inflammatory disease.  Cryotherapy works with the body’s natural systems to reduce inflammation and increase metabolism. An avid learner and researcher, he gathers the latest science from doctors, therapists, and scientists from around the world to find the best ways to address the human system from an engineering perspective.  His team now offers a variety of services to support the human body in healing without surgery or medication, but modalities such as light therapy and lymphatic drainage, in addition to whole and local cryotherapy.

Dr. Bob Harding

Dr. Bob Harding is an innovative physician who believes food is the best medicine and that optimizing your lifestyle for your genetic blueprint can create a healthy vibrant life.  In his medical practice, he saw chronic illness in the lives of people his own age and recognized a major contributing factor not addressed in conventional medicine:  lifestyle. Once working long stressful shifts as an ER doctor, he transformed his body from one struggling with obesity, relentless heartburn and pre-diabetes, to a slim (losing 40 pounds) physique with no more symptoms.  Not only did Dr. Harding use low-carb eating, specific supplements, stress reduction, and hormone optimization to create these drastic shifts, he also addressed another missing component: mindset. Shifting the narrative of how he sees his own life has been key to success on his journey.  He now helps his clients reach their human potential by working with them to develop Personalized Human Optimization Programs to fit their goals.

Sam Harris

Sam Harris is the author of five New York Times best sellers and has published work in top outlets like The New York Times, Time, Scientific American and The Economist. His writing and public lectures cover a wide range of topics—neuroscience, moral philosophy, religion, meditation practice, and human violence,—but generally focus on how a growing understanding of ourselves and the world is changing our sense of how we should live. He also hosts the Making Sense Podcast, in which he explores the most important questions about the human mind, society and current events.  As an avid meditation advocate, Sam has created the Waking Up Course for anyone who wants to learn to meditate in a modern, scientific context.

Dr. Mark Hoch

Dr. Mark Hoch has a background in biological sciences, neurobiology and behavior. He instinctively knew that so much was missing in healthcare education and his mission has been to discover and master diagnosis and health optimization on all levels of human health.  This includes the physical (biochemistry, hormones and biomechanics), emotional, mental, social, environmental and spiritual aspects of what it means to be fully human. He is now bringing all that experience to health programs for you through the Apeiron Center for Human Potential.  There he offers an integrated model of modern medicine and the latest cutting edge genetic science to infinitely expand human capacity.

Chad Howse

Chad Howse is the founder of Chad Howse Fitness and Average 2 Alpha with a mission to motivate and inspire men to be the best man they can be.  By incorporating what he has dubbed, “The Man Diet”, he is fighting the epidemic that leaves men impotent, unable to build muscle or burn fat, lethargic, and depressed: low testosterone.  His sites provide resources on relationships, health, and fitness addressing the common challenges the modern man faces.

Dr. Mark Hyman

Dr. Mark Hyman, believes that we all deserve a life of vitality and is dedicated to tackling the root causes of chronic disease by harnessing the power of Functional Medicine to transform healthcare. Dr. Hyman is a practicing family physician, a ten-time #1 New York Times bestselling author, and an advocate in his local communities for better nutrition and health.  “Your fork is the most powerful tool to transform your health and change the world, ” he says. He is a contributor to The Huffington Post and has been featured as an expert on many media outlets such as the Today Show, Good Morning America and The Dr. Oz Show.  His podcast, “A Doctor’s Pharmacy” provides expert interviews and education on the latest trends and research in Functional Medicine.  He also provides various weight loss programs and supplements.

Chris James

Chris James began his journey outdoors foraging medicinal and edible plants, hiking, hunting and camping in the woods as a child.  After a serious job accident that resulted in numerous traumatic injuries, he began to research ways to heal himself and make his body and mind operate at peak levels.   Soon thereafter, optimal health and performance through biohacking and ancestral health became his biggest passion and he founded PrimalHacker: a comprehensive resource for athletes, executives and entrepreneurs to perform better, feel better and live longer.  “Sitting is the new smoking,” Chris says. Since most people sit behind a desk for work, he’s helping people offset that with lifestyle changes involving technology, diet, movement and various other cutting edge therapies.

Dr. Anthony G. Jay

Dr. Anthony G. Jay, is the President and CEO of AJ Consulting Company. Dr. Jay has specialized in researching viruses and their inhibitors connected to fatal diseases such as HIV and Alzheimer’s disease. This has led him to his current work at Mayo Clinic in doing advanced research, epigenetics, and infrared light.  Dr. Jay is a bestselling author of Estrogeneration, a book that identifies specific artificial estrogens in our everyday environment and educates the reader on ways to take their health back.  His website provides resources and recommendations on how to reduce estrogenic exposure and optimize health with DNA analysis and biohacking.

Dr. David Jockers

Dr. David Jockers is a doctor of natural medicine, functional nutritionist, and corrective care chiropractor. His mission is to empower people with science based solutions to have a healthy and vibrant lifestyle.  He offers revolutionary online programs, recipe guides, meal plans and video instructions such as “The Sugar Detox,”  and “The Cancer Cleanse” to name a few.   Dr. Jockers speaks around the country on topics such as weight loss, brain health, functional exercise, natural detoxification and disease prevention.  He also sees patients from all over the world at his Georgia clinic, Exodus Health Center, where he helps customize specific lifestyle plans to improve performance and live with less pain and more energy.

Dr. Isaac Jones

Dr. Isaac Jones has been named “the doctor of the future” and is a functional health expert and chiropractor who is passionate about helping executives and entrepreneurs access high performance through human potential healthcare. He and his wife, Erica, own one of the largest virtual health consulting companies in the world. He uses cutting-edge strategies such as lifestyle genetics, cellular detoxification and advanced customized nutrition solutions to create transformational results for his clients.  His clinically proven strategies create amazing results in his 6 month programs- with an average of 3x increase in energy, 2x of productivity, and an average of an 80% reversal of common disease promoting factors.

Dr. Sandra Kaufmann

Dr. Sandra Kaufmann has been recognized as “Best in Medicine” by the American Health Council.  She has an avid interest in the science of anti-aging and utilizes her knowledge in cell biology, human pharmacology and physiology to curb the effects of time on the human body.  She knows that while aging cannot be stopped entirely, with today’s science we can vastly decelerate the process with the Kaufmann Protocol. The Protocol organizes these various theories of cellular aging into seven tenets: DNA, Cellular Energy, Cellular Pathways, Quality Control, Immune System, Individual Cells, and Waste Management.  She offers both a book and now an app that allows the user to select from several pre-made, well tested regimens scientifically designed to address specific medical concerns.

Daniel Kelly

Daniel Kelly is a writer and entrepreneur who is extremely passionate about men’s health and fitness. Daniel is a leading European authority for men under 35 on testosterone optimization therapy, fitness training, mindset and men‘s health. He believes that health is not something that‘s given to you – it’s something you have to work at.  With a shift in societal and environmental norms in the last few decades, he helps men transform their approach to health and fight against the factors that degrade their bodies. He is the author of “Optimized Under 35” and you can also find additional resources at Optimized Army

Dr. Farhan Khawaja

Dr. Farhan Khawaja aka “Doc Testosterone” is a professionally trained neuroscientist and health fitness educator. He specializes in developing state-of-the-art diet, lifestyle and fitness programs to naturally boost testosterone levels in men.  He is the creator of Aphro-D: a 100% natural formula consisting of 4 organic ingredients with scientifically-proven effects on male vitality. His Aphro D Academy provide workshops, videos, and articles to help men reclaim their masculinity and achieve peak sexual performance.

Pete Koch

Pete Koch is a fitness expert, retired NFL defensive end (Bengals, Chiefs and Raiders), Hollywood actor and Youtube host. His passion for helping people has propelled his decades long career as a fitness and motivation coach to celebrities, athletes and regular folks who want to look, move and feel their very best. Pete is expert at melding scientifically proven training methodologies with clinical experience and motivational talk to yield maximize results. He trains people of all ages and levels of physical condition to help them achieve their fitness, weight loss and overall health goals.

Dr. James Leonette

Dr. James Leonette is an award winning chiropractic physician and has been named “2018 Winner Circle Doctor of the Year” and “2017 Chiropractor of the Year” by The Masters Circle. Dr. Leonette has extensive education and training in medical and alternative medicine fields such as functional healing, epigenetics coaching, and nutritional therapies.  He is the founder of Alpha Emerged- a platform founded on providing individualized wellness solutions through 100% personalized strategies and recommendations plus in-depth coaching. From weight loss, to sex drvie, to mental clarity, Alpha Emerged addresses your most pressing concerns through advanced lab testing and genetic interpretation for maximum health results!

Dr. Jeffry Life

Dr. Jeffry Life is one of the healthiest and athletically fit 78 year olds in the world.  But it wasn’t always that way. At 59 he found himself overweight with achy joints and poor health.  After seeking expert support he became the Grand Champion in Bill Phillip’s 1998 Body-for-LIFE contest. But he started losing ground as he edged toward 63, losing muscle mass, energy, and his libido.  After applying Anti-Aging Medicine, within a couple weeks he became a vibrant, healthy and happy man. This became the catalyst that moved him from Family Medicine to healthy aging medicine.  He currently has a thriving practice in Charleston, West Virginia and has authored three books. He believes it is never too late, nor too early, to start living a healthier lifestyle and empowers his clients to achieve their fitness and health goals through his cutting-edge high touch programs.

Dr. Bruce H. Lipton

Dr. Bruce H. Lipton is an internationally recognized leader in bridging science and spirituality. Dr. Lipton began his scientific career as a cell biologist. His research on muscular dystrophy and cloning human stem cells focused upon the molecular mechanisms controlling cell behavior.  Dr. Lipton started examining the principles of quantum physics and his research revealed that the environment controlled the behavior and physiology of the cell, turning genes on and off. His discoveries were a foreshadow of the science of epigenetics. With his deepened understanding of how the mind controls bodily functions, he now educates on leading-edge science and its connection with mind-body medicine and spiritual principles.  He is the bestselling author of The Biology of Belief and a recipient of the 2009 Goi Peace Award.

Dr Ben Lynch

Dr Ben Lynch is the best-selling author of Dirty Genes and President of Seeking Health, a company that helps educate both the public and health professionals on how to overcome genetic dysfunction. As a Doctor of Naturopathic Medicine working in environmental medicine he discovered the gap that epigenetics could fill and made it his mission to bring that cutting-edge science right into the doctor’s office through education and supplementation. If you’ve gotten your genetic challenges from websites like 23andMe and are massively confused by the wildly contradictory information, his StrateGene system can help.  It zeroes in on the genetic abnormalities that pose the greatest challenges in people’s health and then provides comprehensive plans for overcoming those challenges. He has quickly become the go-to guy on treating genetic abnormalities through diet, supplements, and lifestyle.

Aubrey Marcus

Aubrey Marcus is the founder and CEO of Onnit, a lifestyle brand based on a holistic health philosophy he calls Total Human Optimization.  As an author of a New York Times bestselling book, “Own the Day, Own Your Life” and host of the Aubrey Marcus Podcast, Aubrey leads with vulnerability and honesty about several areas of life, with a focus on health, mindset, relationships (he is an open relationship with his fiance) and spirituality.  Aubrey is most passionate about the healing effects of psychedelic medicine, and speaks openly about his experiences with Ayahuasca as a pathway to personal transformation.

Mike Matthews

Mike Matthews wants to revolutionize the fitness industry by debunking myths and providing science-backed techniques to create a healthy physique.  Mike had spent years scoring fitness magazines and following ‘trends’ but it wasn’t until he researched and applied the latest science that he got the lean and strong body he wanted.  His strength skyrocketed and his energy was through the roof all by spending less time in the gym, doing less cardio, and eating foods he actually liked!  “The real science of getting into incredible shape is very simple—much simpler than the fitness industry wants us to believe,” he says.  As author of Bigger, Leaner, Stronger and founder of Legion Athletics, his mission is to fight mainstream health and fitness pseudoscience and reform the sports supplement industry.

Dr. Emeran Mayer

Dr. Emeran Mayer is a professor and director of multiple medicine departments at UCLA.  He is a world renowned gastroenterologist and neuroscientist with 35 years of experience in the study of clinical and neurobiological aspects of how the digestive system and the nervous system interact in health and disease.   His current research is on the role of the gut microbiota and brain interactions in emotion regulation, chronic pain and in obesity. His best selling book, “The Mind Gut Connection”, is a culmination of his study, sharing about the connection of the mind to mood and health.

Ben Pakulski

Ben Pakulski is an IFBB body builder and founder of the #1 Best selling muscle building program, MI40.  He also hosts the popular Muscle Intelligence Podcast and is an international speaker who educates audiences on the practical, scientific, and mental aspects of living a healthy and fit life.  In the gym, he helps his clients create a personalized approach to their goals with clear steps on how to achieve them. Ultimately, Ben wants to change the paradigm of muscle building: to encourage fitness enthusiasts of all ages and backgrounds to approach their goals with introspection, mindfulness, and strategic thinking.

Dr. Kirk Parsley

Dr. Kirk Parsley creator of Sleep Remedy is most known for his expertise in sleep medicine.  As a former Navy SEAL and Naval Medical Officer he consults and lectures worldwide on sleep, wellness, and hormonal optimization.  He has discovered that the most under-used tool in the world for enhancing performance is quality sleep. Doc Parsley’s Sleep Remedy is designed to restore commonly deficient nutrients associated with sleep through a proprietary blend that provides the body what it needs to aid the natural sleep cycle.

Sachin Patel

Sachin Patel is a father, husband, philanthropist, coach, author and speaker. He founded The Living Proof Institute as part of his own personal health transformation. Sachin’s philosophy is that “The doctor of the future is the patient.” He’s actively doing whatever it takes to keep people out of the medical system by empowering them through education, self-care, and remapping their mindset. He believes health begins at home. Sachin now coaches functional medicine practitioners around the world. Learn more at

Dr. Rhonda Patrick

Dr. Rhonda Patrick is a groundbreaking researcher and scientist who is dedicated to the pursuit of longevity and optimal health. She shares the latest research on nutrition, aging, and disease prevention with her audience. Some of her frequently used topics include micronutrient deficiencies and the diseases of ages as well as the role of genetics in a person’s health status. She advocates for the importance of mindfulness, stress reduction, and sleep. It is Dr. Patrick’s goal to challenge the status quo and encourage the wider public to think about health and longevity using a proactive, preventative approach.

Dr. Joseph Raffaele

Dr. Joseph Raffaele is a researcher and educator of Age Management Medicine which helps advance innovative, evidence-based approaches to extending “healthspan”.  This entails keeping the body young and vital whatever its chronological age. Dr. Raffaele has created software that gives an analysis of biomarkers of aging and physiological age for each organ system and the body as a whole.  He is the co-founder of PhysioAge Medical Group, a national clinical practice that uses bioidentical hormone replacement therapy, individualized nutritional supplement programs, diet, and fitness strategies targeting the aging process.  He has appeared on the Today show, National Public Radio (NPR) and several other media outlets sharing his breakthrough technology.

James Schmachtenberger

James Schmachtenberger realized early that his calling was to solve big problems.  Starting as an advocate and business owner in the medicinal cannabis industry, he got introduced to the science of ‘biohacking’ and started the Neurohacker Collective in 2015.  The idea is simple: build a global movement to upgrade human capacity and empower individuals to make good choices for their health. Neurohacker Collective offers leading information and top-of-the-line products for self-directed neurological optimization based in complex systems science.  Neurohacker Collective’s scientific approach focuses on supporting the body’s ability to self-regulate, rather than overriding regulatory systems with chemicals. The company began with a focus on psycho-affective products with the launch of their Qualia nootropic line but now offers various supplements and resources such as a podcast and blog.

Dr. David Sinclair

Dr. David Sinclair, named one of TIME magazine’s “100 most influential people in the world”, is a Harvard Medical School professor in the Department of Genetics and co-Director of their Center for the Biology of Aging.

He is best known for his work on understanding why we age and how to slow its effects through genetic, biophysical, and pharmaceutical approaches.

Dr. Sinclair is the co-founder of several biotechnology companies and his work is featured in five books, two documentary movies, and interviews like 60 Minutes. He is an inventor on 35 patents and has received more than 25 awards and honors for his cutting edge work. Check out what he is up to around genetics and anti-aging!

Dr. J. Richard Steadman

Dr. J. Richard Steadman is a retired sports medicine orthopaedic surgeon in Vail, Colorado, who specialized in knee injuries and disorders. He is the Founder of The Steadman Clinic, as well as the Founder of the Steadman Philippon Research Institute. Dr. Steadman is a renowned and award-winning innovator in the field of orthopaedic sports medicine. He is internationally known for the development of several advanced surgical procedures for the knee. His technique, the “package” is used to restore normal comfortable movement to a painful arthritic knee. He is also known for the “Microfracture” surgical procedure that can delay the need for more invasive procedures. As a result, Dr. Steadman and his clinic, have been sought out by professional athletes and public figures alike.

Dr. Daniel Stickler

Dr. Daniel Stickler is the Medical Director of Neurohacker Collective and cofounder of the Apeiron Zoh Inc. Disheartened by “sick care”, he believes the ideal solution for long term wellness is a holistic and allopathic approach.  After 10,000+ hours of research, he has found the answer to an optimal life:  the DNA code. But that doesn’t mean the solution is only genetic. Dr. Stickler says, “Only 20% of longevity is genetic. The rest is up to us. New research indicates the epigenetic clock can be impacted by what we do in our daily lives.” His latest research has informed the development of his Human Potential Medicine- an integrated, biospheric systems-approach that combines modern medicine with leading-edge genetic science.

Dr. Eric Topol

Dr. Eric Topol was voted “Most Influential Physician Executive in the US” in Modern Healthcare’s 2012 poll.  His specialty is in genomic and wireless digital innovative technologies that reshape the future of medicine. As a practicing cardiologist, he has led worldwide clinical trials to advance care for heart disease.  In the cardiac industry, his research has been the driving force behind a few discoveries. Those including how genes can increase susceptibility for heart attacks and how to use this knowledge to prevent blood clots.

Dr. Jean-François Tremblay

Dr. Jean-François Tremblay is one of the world’s leading experts on peptides. Jean-François studied Exercise Physiology, Biochemistry, and Pharmacy. Dr. Tremblay has been researching peptides and SARMS since the 90s. He is now a researcher at UQAM. His focus on peptides is on their practical applications in sports performance, anti-aging, and health in general.

Nelson Vergel

Nelson Vergel is a chemical engineer whose search for cutting-edge health resources started when he was diagnosed with HIV over 30 years ago during a time when HIV was a death sentence.  Through research, he quickly became a leading advocate in the health field as a long term survivor.  As an author, he has published multiple books on hormone management and healthy aging. His commitment is to provide integrative medicine education and resilience-building resources to as many men as possible.

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In Male 2.0™, Dr. Tracy Gapin has turned everything we once thought we knew about men’s health and performance upside down. The old model of how to be “a man” is broken. A man who works himself to death.  Unfortunately, a man who tries to NOT get sick but isn’t really healthy either.  And a man who takes a pill for every ill but is never really cured. That was Male 1.0. Now, imagine being THE MAN ─ owning your performance in the bedroom, the weight room, and the boardroom. Living a fully optimized life. Becoming limitless. This is Male 2.0!

Tracy Gapin, MD, FACS  is a board-certified Urologist,  world-renowned Men’s Health & Performance Expert, Author, and Professional Speaker. Using state-of-the-art biometric monitoring, nutrition, and lifestyle intervention, Dr. Gapin coaches Fortune 500 executives and evolutionary leaders of business, sports medicine, and high performance. He specializes in cutting-edge precision medicine with an emphasis on epigenetics, providing men with a personalized path to optimizing health & performance.

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Anti-Aging Tips For Men


anti aging tips for menClose-up shot of a handsome young man with towel in his neck admiring looking at his face in the bathroom mirror.

Traditional doctors approach aging as something that is imminent, unavoidable, and uncontrollable. Their goal is to merely treat your age-related symptoms as they pop up, like a medical version of whack-a-mole. 

But I view aging VERY differently. 

Science has shown us that there’s a lot we can do to slow, and actually reverse, the course of your aging process. That’s because healthy aging is NOT about hitting the genetic jackpot. Instead, it’s about adopting preventative strategies that slow the cellular processes associated with aging, improve your immune system, prevent disease, and ultimately boost your sense of youth and vitality.

How Inflammation Impacts Aging

There’s one factor that dramatically speeds up the process of aging – inflammation. In fact, chronic inflammation underlies nearly every disease associated with aging, including hypertension, cardiovascular disease, dementia, arthritis, cancer and diabetes, just to name a few.[1]

Chronic inflammation may not directly cause aging per se. Rather, it acts like gasoline, turning the normally smoldering embers of cellular degeneration into a raging fire that causes destruction throughout the body and brain. Inflammation wreaks havoc on your immune system, your gut health, your brain health and your mental wellbeing.

Unfortunately, our modern routines are riddled with factors that increase inflammation—from highly processed diets to a sedentary lifestyle to environmental toxins. But it doesn’t have to be that way. With a few tweaks to your daily regimen, you can smother the flames of inflammation and be on your way to living a long, energetic, disease-free life.

How to Reduce Inflammation and Promote Healthy Aging

1. Eat for Life

If you are like most people, your major source of inflammation comes served on your dinner plate. Eating a typical American diet high in omega-6 poly-unsaturated fats (think canola oil, safflower oil, etc.) , highly-processed oils (think ‘partially hydrogenated’ anything), and refined sugars all directly promote inflammation and increases your risk of disease. Conversely, eating a healthy diet reduces inflammation, boosts your immune system, and protects you against both infectious and chronic diseases.

Let’s break down the three key pillars that form the basis of a healthy, anti-aging diet.

The first pillar involves choosing complex carbohydrates over simple ones.

Simple carbs are found in anything made with sugar, but they are also found in things we don’t consider sweet, like white bread, potatoes, pasta, white rice, pizza dough and pasta.

What makes simple (or refined) carbohydrates unique is that they’ve been stripped of all their fiber, bran, and nutrients. As a result, your body is able to quickly break them down into sugars, which sounds like a good thing but it isn’t. Eating simple carbs floods your system with sugar, resulting in body-wide inflammation

This sugar spike also triggers your pancreas to create a surge in insulin in order to clear the sugar from your bloodstream. But all that insulin makes you feel hungry again, which is why we tend to crave simple carbs rather than vegetables. 

Over time, this dramatic rise and fall in blood sugar causes you to overeat, gain weight (especially dangerous belly fat), and develop insulin resistance (i.e., type-2 diabetes). It also causes unhealthy fluctuations in your mood and energy levels. And if that isn’t bad enough, a diet high in simple carbs puts you at greater risk for high blood pressure, heart disease, cancer, depression and bipolar disorder.[2, 3]

Simple carbs are also dangerous because they produce a particularly nasty substance called Advanced Glycation End Products (AGEs). AGEs are toxic molecules that form when protein or fat combines with the sugar in our bloodstream.[4

When AGEs accumulate, they form a sticky, inflexible substance that clogs our blood vessels and coats our major organs, sometimes resulting in organ failure. AGEs promote oxidative stress, which is a fancy way of saying they make our cells old before their time. Scientists are just starting to discover the ways in which AGEs drive age-related illnesses, but what is clear is that consuming a healthy diet is the main way to keep these toxic molecule levels low.[5]

Now trying to quit anything cold turkey is hard, so instead of just cutting out sugars and simple carbs, think about replacing them with complex carbs. 

  • Swap out sugary desserts with fresh fruit like strawberries or apples. 
  • Switch white bread with wheat or even better, a lettuce leaf. 
  • Opt for brown rice, lentils, or an ancient grain like amaranth or quinoa versus white rice.
  • Switch from regular pizza dough to a cauliflower crust. With a few creative tweaks to your diet, you are less likely to feel deprived and more likely to stick with your new eating habits.

The second pillar in an anti-aging diet is eliminating bad fats and incorporating good fats. In the 1980s, fat got a bad rap. Doctors argued that eating a diet high in fat skyrocketed cholesterol and caused heart disease. 

But experts now recognize this assumption was wrong. In truth, there are good fats and bad fats and a key to anti-aging is knowing the difference.

Generally, fats fall into these broad categories:

  • Trans fats: Trans fats are the worst kind of fats because they raise your LDL (bad cholesterol) and triglycerides and lower your HDL (good cholesterol). For this reason, the FDA started banning trans fats in 2018, but they can still be found in some food sources, including vegetable shortening, fried fast foods, and some brands of microwave popcorn.
  • Omega-6 polyunsaturated fats: These are the fats found in oils such as safflower oil, sunflower oil, canola oil, soybean oil, corn oil, and most other oils that are used for cooking. Unfortunately, when you eat out at a restaurant, almost ALL of the foods are cooked using these oils. These fats stimulate your fat cells to produce cytokines, which are proteins that cause low-level, chronic inflammation. They have been linked to a number of age-related, inflammatory-based illnesses, including diabetes, heart disease, cancer, and arthritis.
  • Omega-3 polyunsaturated fats: These are considered to be “heart-healthy” fats because they raise your HDL and lower your LDL, thereby protecting you against vascular diseases. These fats are found in fish, vegetables such as avocados, and healthy nuts.
  • Monounsaturated fats: These are also considered to be the most “heart-healthy” fats. They reduce inflammation, promote cellular efficiency, and protect you from vascular disease. These fats are found mostly in olive oil, and healthy nuts such as almonds and macadamia nuts.
  • Saturated fats: A diet high in saturated fats can increase your risk for developing heart disease and vascular disease, which is why most nutritionists recommend limiting saturated fats to no more than 10% of your daily fat intake.[6] Saturated fats are found in animal-based foods such as red meat, cheese, and dairy, as well as plant-based oils like coconut and palm oil. These oils are also commonly used in commercially produced baked goods like boxed cookies and crackers.

Both are types of the polyunsaturated fats (omega-3 and omega-6) are considered “essential fats” which means the body requires them for normal functioning. Our body doesn’t naturally produce these fats, which means the only way to get them is through our diet. But an important distinction is that omega-6s are pro-inflammatory and omega-3s are anti-inflammatory.

Omega-6 fats, like soybean oil, are far cheaper which means they are more likely to appear in processed foods. And since processed foods make up a significant proportion of the American diet, we as a nation are consuming too many omega-6s and not enough omega-3s. 

The recommended ratio of omega-6 to omega-3 fatty acids in 4:1, but the Western diet ratio is more like 10:1 or even 50:1![8] This imbalance increases body-wide inflammation and negatively alters cell-membrane health.

To correct this imbalance, try to reduce the amount of omega-6s in your diet and boost the omega-3s. An excellent way to do this is to follow the World Health Organization’s recommendation to consume two servings of oily fish per week. 

In fact, research shows people who eat seafood 1-4 times per week are less likely to die of heart disease or strokes.[9] You can also stock up on flaxseeds, chia seeds, walnuts, avocados, and grass-fed beef, which are all high in omega-3s.

Excessive saturated fats also promote inflammation, weight gain, and ultimately aging. Depending on your genetics (remember how important ‘epigenetics’ is?), some people can tolerate more saturated fats than others. But for some, consuming more than 10% of your fat intake as saturated fat can dramatically increase your risk for early ALzheimer’s Disease and cardiovascular disease.

But here is the good news—the negative impact of these fats can easily and quickly be reversed. One study found that after just two weeks of swapping out saturated fats with monounsaturated fats, cytokines were reduced and as a result, brain functioning was significantly improved.[7] So by making just a few simple swaps to your diet, you can quickly reduce inflammation, prevent disease, and enable your body and brain to age healthier.

The third pillar of an anti-aging diet is to “eat the rainbow,” which means eating a wide range of vegetables and fruits to ensure a wide range of vitamins and minerals.

Focus on incorporating dark greens (broccoli, watercress, kale) and brightly colored vegetables and fruits (red bell peppers, carrots, blueberries).

Supplements can also help you incorporate important nutrients into your diet. Research supports the use of several anti-aging supplements, including CoQ10 and Vitamin C (to learn more, check out my article on the 7 supplements every man should be taking).

2.Keep Moving

What you put into your body is only half of the anti-aging equation; just as important is what you do with your body. Exercise isn’t just a solution for weight loss. It actually equips your body with the tools it needs to successfully navigate the aging process.

With the rise of wearable tech, there has been an emphasis on counting the number of daily steps to improve health, but there is no scientific evidence to support the well-known “10,000 steps a day” rule. Instead, what you should be focusing on are the minutes you spend each day in your target heart rate. 

Heart Rate Matters

Your target heart rate varies depending on your age. First, you need to calculate your maximum heart rate (MHR), which is 220 minus your age. So a 40-year old man would have a MHR of 180.

The key to heart-benefiting exercise is to work out at the proper intensity and duration. In terms of intensity, you want to exercise hard enough to raise your heart rate, but not so much that it reaches all the way up to your MHR. 

Moderate aerobic activity is generally defined as 50-70 percent of your MHR. So in the case of our 40-year old man, that would be a heart rate range of 90-126. 

Vigorous aerobic activity is defined as 70-85 percent of your MHR, which for a 40-year old man would be 126-153. Either way, you should always avoid going over the 85 percent upper limit since it offers no health benefits and can actually strain your heart.

In terms of duration, the Mayo clinic recommends you strive for at least 150 minutes of moderate aerobic activity—brisk walking, swimming, yard work and household chores—per week, but you could go all the way up to 300 minutes for maximum benefit.[10] If instead you prefer vigorous aerobic activity—running, aerobic dancing—strive for at least 75 minutes per week.

Keep in mind that exercise doesn’t just keep your heart young, it keeps your brain young too. Once study published in the Journal of Alzheimer’s Disease found that a lack of exercise in older adults raised their risk of developing dementia to a level that was equivalent to people who were genetically predisposed to the disease.[11]  

Studies like this prove that despite what your genes say, you have a great amount of control over your aging process. This is just one reason why I’m so passionate about epigenetics—the idea that your external environment affects the way our genes behave. And to clarify, your environment is not just chemicals or toxins in your environment, but also what you eat, how you move, how you breathe, how you sleep, etc.. 

In addition to aerobic exercise, the other essential component to an anti-aging workout is strength training. As we age, muscles lose their flexibility and shrink. 

In fact, after the age of 30, you lose 3-5 percent of your muscle mass every decade, and men on average lose 30 percent of their muscle mass over their lifetime.[12] On top of that, ligaments, tendons and connective tissues dehydrate and degrade as we age, further reducing our mobility and increasing risk of injury. 

But as exercise physiologist Dr. Thomas Storer makes clear, “Older men can indeed increase muscle mass lost as a consequence of aging. It takes work, dedication, and a plan, but it is never too late to rebuild muscle and maintain it.”[12]

To kick start muscle gain, focus on high rep workouts rather than heavy weights. A typical program might include 8-10 different exercises that target all major muscle groups, with 2-3 sets of 12-15 reps, performed 2-3 times per week. Once this program is established, you can increase the weights, drop the number of reps down to 10, then eventually work your way up to 15 and repeat the process. 

And don’t forget that muscle building requires protein. According to the American College of Sports Medicine, men engaging in strength training should consume 0.5-0.8 grams of protein per pound of body weight.[13] That means a 165-pound man generally needs around 80-135 grams per day, although remember that your genetics direct specifically how much protein your body needs (epigenetics!!).

Lastly, consider supplementing with things known to prevent muscle loss, including fish oil, vitamin D, and hormone replacement therapy. And don’t forget to fortify your bones too, with calcium and vitamin D (take these together for maximum absorption), as well as vitamin C, B12, and magnesium.[14]

3. Build a Better Brain

Our body isn’t the only thing that degrades as we age. The older we get, the longer our brains have been exposed to inflammatory triggers like toxins, chronic stress, and unhealthy foods. Only now are scientists discovering that conditions we assumed were inevitable as we age, like dementia and Alzheimer’s disease, are actually caused by brain-wide inflammation.[15]

The good news is that most of the things we’ve discussed that prevent the body from age-based decline benefit the brain as well. Exercising, avoiding sugar, keeping your cholesterol in check and maintaining a healthy diet are all excellent ways to protect your brain against aging. Additional strategies include getting 7-8 hours of sleep every night, limiting alcohol, quitting smoking, and reducing stress.

Certain supplements have also been shown to preserve cognitive functioning and prevent neurodegenerative conditions like Alzheimer’s and Parkison’s disease.[16] For example, vitamin D and B12 play vital roles in memory formation and cognitive functioning, which is why a deficiency in these vitamin has been linked to cognitive impairments, depression, and Alzheimer’s disease in older adults.

Fat is another important factor when it comes to brain health. Omega-3s account for 40 percent of the fatty acids found in our brains cells and they are especially concentrated at the synaptic connections where all communication between brains cells occurs.[17] Research shows higher intake of omega-3s is associated with larger brain volume and a decreased risk of developing Alzheimer’s disease, so consider adding a fish oil supplement to your daily routine.

Putting it All Together

Aging isn’t something you have to take lying down. With just a few tweaks to your routine and the addition of a few foods and supplements, you can actively slow down or even reverse the effects of aging. 

To see the power of lifestyle changes in action, look no further than a study published in The Lancet Oncology.[18] In this study, researchers had a group of men start a plant-focused diet, exercise for 30 minutes six days a week, and practice yoga or meditation for three months. After the three months, the researchers examined the men’s telomeres. 

Telomeres are a lot like those plastic endcaps on shoelaces that stop the laces from fraying and falling apart. In each of our cells, we have telomeres that cap off the ends of our chromosomes and keep the DNA strands intact. 

Cells replenish by copying themselves and each time they do, these telomeres get shorter and shorter. Eventually, they become too short to do their job, the DNA becomes damaged and the cell stops working. 

For this reason, the length of our telomeres is considered an indicator of our biological (rather than chronically) age. The shorter our telomeres, the “older” our cells are and the more likely we are to succumb to age-related illnesses.

So what did the study find? After just twelve weeks of adopting these simple lifestyle changes, the men’s telomeres grew by a whopping 10 percent. As lead researcher Dr. Dean Ornish stated, “This study is the first of its kind that scientifically proves you can reverse aging at a cellular level through lifestyle changes.”[19

With some adjustments in your lifestyle, you can turn the clock back on your cells too. If you want to take control of the aging process and feel better, schedule a consultation.  You’ll learn how a personalized health strategy can let you live your life to the fullest.

Men, What is stress doing to your Testosterone?

stress and our testostereone man at desk

Stress is ubiquitous—it affects all of us in one way or another.

Low level stress that you can easily overcome is usually not bad for you. In fact, it can even be good for you. Stress can motivate you, improve your athletic performance, and help you adapt to your environment. 

But long-term or excessive stress can have a profoundly negative effect on your health and even reduce your lifespan. Research shows that stress reduces testosterone levels, which may be one reason why stress is strongly linked with weight gain, poor sleep, and erectile dysfunction (ED)

Getting your stress under control is one of the most important ways to achieve a healthy, satisfying life. In this article, I’ll dive into exactly what stress is and what it is doing to your health, testosterone, and sex life. Then I’ll explain exactly how to beat it. 

What is Stress

We throw the term around all the time, but what exactly is stress?

Stress is a feeling of psychological strain or pressure. It occurs from our own perception of an event or stressor as threatening or challenging to us.

To be clear, stress is not the actual events or stressors in your life.  Your response to those stressors is what triggers your feeling of stress.

Psychologists sometimes classify stressors into four types (1):

  1. Ambient stressors, like noise in a cafe or traffic
  2. Hassles or micro stressors, like not being able to find your keys
  3. Major life events, like getting fired, getting married, or having a child
  4. Crises or catastrophes, like a natural disaster

These have different effects on your overall well-being, but even hassles or micro stressors, when they are constant, can create levels of stress that ultimately affect our health. 

traffic jam - angry stressed businessman driving car

How Stress Affects Health

Stress has a massive physiological effect on our bodies. When we feel stress, our brain sends out a signal to our body and activates a “fight or flight” response. Our pupils dilate, our heart rate increases, and our body releases a number of hormones and chemicals to get us ready to react, such as adrenaline, endorphins, and cortisol.

This response is useful if we’re encountering a situation where we really do need to fight or get away. Athletes, soldiers in combat, or even firefighters benefit from this reaction to stressful situations.

But for most of us, this bodily response is unnecessary. And, when stress is chronic, occurring over a long period of time, these effects can be toxic and dangerous to our health. The amount of stress that you have, and your stress resiliency, can even predict how long you will live.

Risk of disease

One of the most worrying effects of stress on our health is its relationship to disease; research shows that chronic, severe stress vastly increases a person’s risk for several chronic health conditions. 

For example, there’s significant evidence that stress increases the risk of cardiovascular diseases like heart attack, stroke, high blood pressure, and hypertension as well as diabetes and certain types of cancer (2, 3, 4). 

Stress is also clearly associated with mental illness, including depression, schizophrenia, and anxiety (5, 6).

Immune Function

Stress has been found to reduce immune function (7). Research has demonstrated that stress can cause a person to be more susceptible to illnesses like colds (8). Scientists have suggested that stress can affect immune system function at the cellular level, changing the body’s chemical immune response. They’ve found that individuals that report more stress tend to have lower immunity and increased inflammation (7).

Poor lifestyle habits

The way that we cope with stress may also have an impact on our health. When individuals cope with stress by consuming excessive alcohol, smoking, or binge-eating, the result is poorer health. Stress can cause some people to engage in unhealthy habits as a way to cope with the psychological discomfort (9). 

Stress can affect your genes

Epigenetics refers to a process whereby gene expression, or activity, is altered by the environment although the actual genetic sequence is not changed. 

Researchers have found that stress can cause epigenetic changes resulting in negative health outcomes. 

What does all this mean? It means that stress may be able to actually change how your genes are expressed such that you are predisposed to have worse health outcomes. 

How Stress Affects Testosterone and Erectile Dysfunction

Stress has such a powerful effect on us in part because it’s psychological. It affects the hormonal balance in our body, but it also affects our mental health. Both of these things can impact sexual function and performance.

One of the ways that stress impacts sexual function is through testosterone.

What is testosterone?

Testosterone is often called the “male sex hormone”. It plays an important role in several bodily functions for men, including the initial development of the testes and prostate. In adults, testosterone has many surprising effects including being critical to the production of sperm and semen, healthy libido, and even muscular development.

Many men suffer from “low T”. What is low T? It’s a condition where a man’s body does not produce sufficient testosterone for optimal function.

Low testosterone can be caused by various lifestyle factors, including diet, exercise, and poor sleep. Age alone may also be a factor since the production of testosterone tends to decrease with age. Men over the age of 50 tend to experience a 1% decline in testosterone levels every year.

Some of the symptoms of low testosterone include: 

  • Erectile dysfunction
  • Low fertility
  • Loss of muscle mass
  • Anxiety and depression
  • Weight gain
  • Low libido and sex drive
  • Weaker bones
  • Reduced energy
  • Less body hair
  • Foggy brain

Stress has been shown to directly affect testosterone levels. When you’re stressed, your body releases the stress hormone cortisol. And high cortisol levels crush your testosterone. Research has found a clear association between high cortisol levels and low levels of testosterone (13). 

The lower testosterone levels caused by stress, in turn leads to low energy, weight gain, loss of mental focus, and loss of sexual function.

Stress Causes Erectile Dysfunction

Stress is one of the most common causes of ED (14).

Sexual function depends on the complex interaction between physiological and psychological factors. Stress affects both. It causes your body to produce less testosterone, which contributes to difficulty getting an erection. It can also affect the psychological processes associated with sexual arousal. 

Finding ways to effectively cope with stress is an essential part of creating a healthy lifestyle, achieving optimal testosterone levels, and supporting a fulfilling sex life. 

Reduce Stress to Improve your Health, Testosterone, and Sex Life

Great, we need to address stress for better health, more testosterone, and great sex. 

But how?

Develop stress resiliency

This is one of the most important things that you can do to reduce stress: develop ways to cope effectively with stress and create stress resiliency

Stress resiliency refers to your ability to respond to and cope with the stressors that you face in everyday life. Creating resilience to stress can help you experience it less often, for less time, and thus reduce the negative health effects.

To develop stress resiliency, try the following.

  1. Start to think of stress as an opportunity for growth. Ask yourself: What is the stressor? Why am I stressed about it? Where can I feel the stress in my body? What can I do right now to cope and calm myself down? What can I learn to grow from it?
  2. Develop healthy coping habits. These include exercise, meditation, breathing techniques, hobbies you enjoy, and even sex.
  3. Sleep! Sleep is critical for optimal health, but especially when it comes to stress resilience. Good quality sleep allows your body to heal and recover. And good quality sleep lowers cortisol.
  4. Get social support. Engaging with the important people in your life is one of the most effective ways to cope with stress. Even giving social support can improve your stress. 
  5. Focus on eating good quality food. The foods you eat can directly promote or reduce inflammation in your body, and thus affect cortisol production. 


Exercise is one of the most effective ways to beat back stressors (15). Research shows that people who exercise consistently  are better able to develop stress resilience and reduce the health consequence of stress (16). 

man exercising for stress and testosterone levels


Research is increasingly finding the benefits of meditation on everything from cognitive health to physical energy levels. Meditation also turns out to be an effective way to cope with life stressors, even if you do it for just five to ten minutes a day. 

The benefits of meditation include:

  • Stress reduction
  • Better sleep
  • Feeling relaxed
  • Better focus and attention
  • More positive mood
  • Reductions in depression and anxiety. 

Solutions for Erectile Dysfunction and Low T

Do you think your stress is lowering your testosterone? Here are a few ways that you can increase your testosterone naturally

Lose weight

Body fat and testosterone are connected. When guys have higher body fat levels, their bodies create and release less testosterone. And low testosterone causes your body to store more energy as fat. It’s a vicious cycle.

However, you can reverse it and turn it into a positive cycle. When you start to lose weight, you’ll find that your testosterone levels naturally increase. And, as the testosterone in your body increases, you’ll find it easier and easier to lose more weight (17). Losing weight will also help you to stop ED in its tracks

If you are overweight, make this a priority: lose weight to naturally boost your testosterone. improve sexual function, and improve stress. 


It’s not only effective for coping with stress, but also for increasing testosterone. Numerous studies have found that guys that exercise more tend to have more testosterone. 

The best exercise to boost testosterone is strength training and lifting weights. Studies have found that guys of all ages get a boost of T from weight training (18). Moderate cardio exercise is also great. 

And for another added benefit, exercise is an effective way to prevent and help treat ED.

Testosterone replacement therapy (TRT)

Testosterone hormone therapy can be an effective treatment for some guys that suffer from low T. Testosterone therapy can be given topically, by subcutaneous or intramuscular injection, pellets, or more recently oral medication.  Some of the benefits of TRT include (19):

  • Improved energy
  • Better sexual function and sex drive
  • Increased endurance
  • Enhanced ability to gain lean muscle mass
  • Increased mood and energy
  • Improved cognitive function

There can be risks of testosterone replacement therapy, so make sure you consult with a doctor specialized in men’s health and hormone therapy before deciding whether it could be right for you.

Precision Medicine

These recommendations will help the majority of men reduce stress and improve their health. 

But everyone is different. Every man obviously has unique genetics, and thus responds to his environment differently. This is epigenetics.

Why should you care? There may be things that you should be doing to reduce stress and get healthy that wouldn’t work for other men. Whether it be

Precision medicine is a way to get a health plan tailored to your individual genetic makeup. If you’re suffering from stress, low T, or ED, look for solutions designed specifically for you and your genes. 

Optimize your Health with Dr Tracy Gapin. The body is a complex system.

Conclusion: Don’t Let Stress Get You Down

Everyone experiences stress. If stress becomes chronic, and you lose your ability to cope with it, stress can crush your health, leading to weight gain, low testosterone levels, poor energy, and increased risk of erectile dysfunction.

But when you have effective coping mechanisms and view stress as helpful not harmful, you can overcome it and rise to the occasion. Learning to beat stress will help you boost your immune system, lose weight, feel healthier, and enjoy the benefits of higher testosterone.

If you’re concerned about what stress may be doing to your health and testosterone levels, schedule a consultation to learn how to personalized health advice so you can live your life to the fullest. 

In Male 2.0™, Dr. Tracy Gapin has turned everything we once thought we knew about men’s health and performance upside down. The old model of how to be “a man” is broken. A man who works himself to death.  Unfortunately, a man who tries to NOT get sick but isn’t really healthy either.  And a man who takes a pill for every ill but is never really cured. That was Male 1.0. Now, imagine being THE MAN ─ owning your performance in the bedroom, the weight room, and the boardroom. Living a fully optimized life. Becoming limitless. This is Male 2.0!

Tracy Gapin, MD, FACS  is a board-certified Urologist,  world renowned Men’s Health & Performance Expert, Author, and Professional Speaker. Using state-of-the-art biometric monitoring, nutrition and lifestyle intervention, Dr. Gapin coaches Fortune 500 executives and evolutionary leaders of business, sports medicine, and high performance. He specializes in cutting-edge precision medicine with an emphasis on epigenetics, providing men with a personalized path to optimizing health & performance.

Want more tips to optimize your health?  Listen to the latest podcasts. Click HERE


  1. Wheaton, B., & Montazer, S. (2010). Stressors, stress, and distress. A handbook for the study of mental health: Social contexts, theories, and systems, 171-199.
  2. Dimsdale, J. E. (2008). Psychological stress and cardiovascular disease. Journal of the American College of Cardiology, 51(13), 1237-1246.
  3. Harris, M. L., Oldmeadow, C., Hure, A., Luu, J., Loxton, D., & Attia, J. (2017). Stress increases the risk of type 2 diabetes onset in women: A 12-year longitudinal study using causal modelling. PloS one, 12(2), e0172126.
  4. Moreno-Smith, M., Lutgendorf, S. K., & Sood, A. K. (2010). Impact of stress on cancer metastasis. Future Oncology, 6(12), 1863-1881.
  5. Bartolomucci, A., & Leopardi, R. (2009). Stress and depression: preclinical research and clinical implications. PloS one, 4(1), e4265.
  6. Corcoran, C., Mujica-Parodi, L., Yale, S., Leitman, D., & Malaspina, D. (2002). Could stress cause psychosis in individuals vulnerable to schizophrenia?. CNS Spectrums, 7(1), 33.
  7. Segerstrom, S. C., & Miller, G. E. (2004). Psychological stress and the human immune system: A meta-analytic study of 30 years of inquiry. Psychological Bulletin, 130(4), 601.
  8. Cohen, S., Doyle, W. J., Skoner, D. P., Rabin, B. S., & Gwaltney, J. M. (1997). Social ties and susceptibility to the common cold. JAMA, 277(24), 1940-1944.
  9. Steptoe, A., Wardle, J., Pollard, T. M., Canaan, L., & Davies, G. J. (1996). Stress, social support and health-related behavior: a study of smoking, alcohol consumption and physical exercise. Journal of Psychosomatic Research, 41(2), 171-180.
  10. Mulligan, C. J. (2016). Early environments, stress, and the epigenetics of human health. Annual Review of Anthropology, 45, 233-249.
  11. Glad, C. A., Andersson-Assarsson, J. C., Berglund, P., Bergthorsdottir, R., Ragnarsson, O., & Johannsson, G. (2017). Reduced DNA methylation and psychopathology following endogenous hypercortisolism–a genome-wide study. Nature: Scientific Reports, 7, 44445.
  12. Wein, H. (2010). Stress Hormone Causes Epigenetic Changes. NIH Research Matters.
  13. Rubinow, D. R., Roca, C. A., Schmidt, P. J., Danaceau, M. A., Putnam, K., Cizza, G., … & Nieman, L. (2005). Testosterone suppression of CRH-stimulated cortisol in men. Neuropsychopharmacology, 30(10), 1906-1912.
  14. Rosen, R. C. (2001). Psychogenic erectile dysfunction: classification and management. Urologic Clinics of North America, 28(2), 269-278.
  15. Bond, D. S., Lyle, R. M., Tappe, M. K., Seehafer, R. S., & D’Zurilla, T. J. (2002). Moderate aerobic exercise, T’ai Chi, and social problem-solving ability in relation to psychological stress. International Journal of Stress Management, 9(4), 329-343.
  16. Hsu, Y. C., Tsai, S. F., Yu, L., Chuang, J. I., Wu, F. S., Jen, C. J., & Kuo, Y. M. (2016). Long-term moderate exercise accelerates the recovery of stress-evoked cardiovascular responses. Stress, 19(1), 125-132.
  17. Yassin, A. A., & Doros, G. (2013). Testosterone therapy in hypogonadal men results in sustained and clinically meaningful weight loss. Clinical Obesity, 3(3-4), 73-83.
  18. Craig, B. W., Brown, R., & Everhart, J. (1989). Effects of progressive resistance training on growth hormone and testosterone levels in young and elderly subjects. Mechanisms of Ageing and Development, 49(2), 159-169.
  19. Osterberg, E. C., Bernie, A. M., & Ramasamy, R. (2014). Risks of testosterone replacement therapy in men. Indian journal of urology: IJU: journal of the Urological Society of India, 30(1), 2.


What to Ask Your Doctor Before Starting Testosterone

Man working on laptop at determining questions to ask his doctor about testosterone

Men everywhere are suffering with plummeting testosterone levels. A recent study showed that testosterone levels have declined over 30% in the last 30 years.[1] It has become such a problem that research now indicates that 1 in 4 men over the age of 30 has low levels of testosterone.[2

And declining testosterone levels are associated with significant health issues. Here are just a few symptoms men experience with low testosterone:

  • Low sex drive
  • Erectile dysfunction
  • Weight gain, especially around the midsection
  • Loss of muscle mass 
  • Fatigue and irritability
  • Loss of mental focus
  • Hair loss
  • Loss of bone density
  • Anxiety and depression

Does any of this sound familiar? 

Man with low energy and low testosterone

When my patients complain that they don’t quite feel like themselves, I find they often have low testosterone. One reason men fail to recognize the issue is because the symptoms of low testosterone will often develop slowly over time.  

Men will often come to see their doctor when they struggle with erectile dysfunction, but low testosterone goes far beyond the bedroom. Having a good level of testosterone is vital for all aspects of a man’s health and well-being. 

If you suffer from any of the aforementioned symptoms, it’s time to get your testosterone levels checked by a doctor. In preparation for this visit, here are some key questions you should consider.

How Do I Know if I’m Low in Testosterone?

Testosterone is a hormone produced primarily in the testes for men (and at lower levels, in the ovaries for women), but small amounts are also produced by the adrenal glands. Testosterone is part of the endocrine system and its release and regulation is controlled by the brain’s pituitary gland and hypothalamus.

To test your testosterone levels, your doctor will run some blood work, usually in the morning since that is when your hormone levels are at their highest. “Low testosterone”, or hypogonadism, occurs when a man’s level falls below optimal levels. 

This brings up a critical question: “What is optimal?!”

Most labs define the lower limit of “normal” testosterone levels to be anywhere from 250 to 350 ng/dL, depending on the lab. The problem with this is there is a massive difference between what is considered clinically “normal” and what is optimal – i.e. what men need to actually experience the benefits of healthy testosterone levels. We’ll cover this huge topic in another blog post, but suffice it to say that men typically need much higher serum testosterone levels than what the clinically “normal” range suggests.

Go Beyond Testosterone with Tracy Gapin, MD Free eBook

What Causes Low Testosterone?

A man’s testosterone peaks in early adulthood and naturally reduces as he ages. Once he enters his 30s, his levels begin to decline about 1 to 2 percent each year. Some men don’t start noticing the effects of this decrease until they hit the age of 50, but there are others who start to show symptoms even a decade or two earlier. 

In addition to age, there are a number of potential causes for low testosterone. Injury or infection to the testes and malfunction of the pituitary gland can cause low testosterone, and diseases like obesity, diabetes and cardiovascular disease are all strongly linked to testosterone deficiency. Endocrine disruptors – chemicals and toxicants in our environment – are clearly a major culprit as well. 

Low levels of vital nutrients like zinc or Vitamin D have also been found to correlate with low testosterone. Certain medications can lower testosterone, including asthma inhalers, antidepressants, and antihistamines, as well as chemotherapy.[3] And a number of lifestyle factors, such as smoking, drug abuse, poor sleep, poor diet, and obesity, can lead to low hormone levels.

How is Low Testosterone Treated?

There are a few important concepts to understand before diving into treatment options for men with testosterone deficiency. First it’s key to recognize that treatment requires a comprehensive approach. It’s never as simple as just getting testosterone therapy. It’s critical to be aware that there’s no magical one-size-fits-all solution that works for every man. Treatment varies depending on each man’s underlying health issues, genetics, symptoms, and goals. 

A key aspect of addressing low testosterone is to address underlying health issues and develop healthy lifestyle habits. Losing weight has been shown to directly improve testosterone levels. Research shows that exercise, especially weight training or high-interval training, naturally boosts testosterone.[4] Proper nutrition and sleep are critical aspects of a comprehensive approach to overcoming low testosterone and its associated symptoms. Check out the MALE 2.0 Blueprint to learn how to start incorporating healthy habits into your daily life.

Another common approach is hormone replacement therapy (HRT). Hormone replacement therapy involves artificially raising your testosterone levels via a gel, skin patch, injection or hormone pellet implants.

What Are the Benefits of Hormone Replacement Therapy?

A number of studies back up the claim that testosterone replacement therapy can provide men with real benefits. Here are just a few examples, according to a recent academic review:[5]

  • Muscle gain and improved strength: Several studies found testosterone replacement therapy improves men’s body composition, decreases fat, and increases lean body mass and muscle strength.
  • Increased bone density: Testosterone therapy has been shown to increase bone density, especially among elderly men, which puts them at a reduced risk of injury. 
  • Improved sex drive: Testosterone replacement therapy increases men’s self-reported libido, as well as the frequency of sexual acts. 
  • Improved cognitive functioning: One study found older men’s risk for Alzheimer’s disease decreased by 26% for each 10-unit increase in free testosterone. Additional studies found testosterone improves men’s spatial, mathematical, and verbal reasoning, as well as their memory. 
  • Improved mood and quality of life: Men who receive testosterone therapy report an increase in mood and well-being and a decrease in fatigue and irritability. 

What Are the Risks of Hormone Replacement Therapy?

Clearly testosterone replacement therapy has its benefits, but it is important to realize it is not a panacea. Such therapy is considered most beneficial when used short-term to help your body get back on track or to treat an underlying issue like hypogonadism. But know that like all treatments, this hormone therapy comes with a number of risks and side effects that must be considered. 

Some side effects may include:

  • Acne and oily skin
  • Breast enlargement or tenderness (rare if treated properly)
  • Shrinkage of the testicles
  • Hair loss (rare)

Questions to ask about testosterone and HRT hormone replacement therapy

Additional Questions To Ask Your Doctor Before Starting HRT

 So you’ve decided to proceed with testosterone therapy. First, be aware that you should never attempt testosterone therapy alone –  it should always be done under a doctor’s supervision. But before you start, here are some key questions you should ask your doctor before embarking on a testosterone treatment plan:

  1. What Are Your Doctor’s Qualifications?
  • What expertise and experience does the doctor have in treating men’s health issues generally, and testosterone replacement therapy more specifically? 
  • How long have they been practicing this approach? 
  • Given that the science of HRT (hormone replacement therapy) is consistently evolving, how does the doctor stay up-to-date on the topic?
  • Do they attend conferences, read scientific journal articles, take training courses?
  1. Am I a Good Candidate for HRT?
  • What evidence is there that I need testosterone replacement therapy? 
  • If there is evidence, what potential causes does your doctor suspect?
  • Do I have certain medical conditions (like sleep apnea or an enlarged prostate) that make me a bad candidate for HRT?
  1. Can I Boost My Testosterone Naturally?
  • Are there things in my medical history or lifestyle that could be changed to improve my testosterone naturally?
  • Are there certain foods the doctor recommends to boost testosterone?
  • Are there certain supplements the doctor recommends?
  • How does sleep quality affect testosterone?
  • How does alcohol affect testosterone?
  • What changes in my exercise routine can I make to boost my testosterone?
  1. What Type of Treatment Does the Doctor Prefer?
  • What type of HRT does the doctor prefer (e.g., gel, injection, implant) and why?
  • How will the doctor determine which hormone dose is right for me?
  • How do they track results?
  1. What is the Expected Cost of HRT?
  • Does insurance typically cover the cost of the treatment?
  • What will my out of pocket expenses be? 
  • How long will treatment take?
  1. What Side Effects Are Expected?
  • Will there be pain or inflammation at the injection or implant site?
  • What adverse reactions should I look out for?
  1. What Improvements Can I Expect to See?
  • What symptoms should I expect to see improvements on after starting treatment?
  • How long will it take before I see results?
  • How often will I follow up with my doctor?
  • Will the doctor monitor my progress through routine blood tests or other means?


If you’re struggling with weight gain, low energy, fatigue, diminished sex-drive, or performance issues in the bedroom, know that it doesn’t have to be that way. You can overcome these issues and become unstoppable TODAY!

It’s time to get empowered to take control of your health. Unlock the code to peak performance with the Male Method™ to regain your energy, focus and confidence to feel like a man again. 

We take a whole-body, epigenetic approach to health, focusing on all inputs and how they affect the human system. With the Male 2.0 Method, we utilize science-based precision medicine, personalizing your health based on your unique genetic blueprint. No more guessing!

We utilize cutting-edge age management protocols to reverse the aging process and expand longevity. And we track and leverage your biometric data using state-of-the-art wearable technology to truly optimize your health.

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In Male 2.0™, Dr. Tracy Gapin has turned everything we once thought we knew about men’s health and performance upside down. The old model of how to be “a man” is broken. A man who works himself to death.  Unfortunately, a man who tries to NOT get sick but isn’t really healthy either.  And a man who takes a pill for every ill but is never really cured. That was Male 1.0. Now, imagine being THE MAN ─ owning your performance in the bedroom, the weight room, and the boardroom. Living a fully optimized life. Becoming limitless. This is Male 2.0!

Tracy Gapin, MD, FACS  is a board-certified Urologist,  world renowned Men’s Health & Performance Expert, Author, and Professional Speaker. Using state-of-the-art biometric monitoring, nutrition and lifestyle intervention, Dr. Gapin coaches Fortune 500 executives and evolutionary leaders of business, sports medicine, and high performance. He specializes in cutting-edge precision medicine with an emphasis on epigenetics, providing men with a personalized path to optimizing health & performance.

Want more tips to optimize your health?  Listen to the latest podcasts. Click HERE