Peptide Series: What are the Best Peptides for Weight Loss and Fat Loss? 

There’s a whole new way to add the icing on the cake when it comes to maximizing your fitness and nutrition, and it’s pretty exciting. What are we talking about? Peptides.  You might have even heard some buzz around Peptides for Weight loss.

If you’re looking to lose weight, burn fat, or upgrade your health to the next level, you’re probably starting to hear some discussion surrounding peptides, so let’s dive right in. 

We’re now developing a whole new understanding of exactly what peptides can do and how they can be used for strength, longevity and whole list of other benefits. In fact, it’s so recent that we are still on the frontier – and it’s worth learning even more. 

 Let’s take a look at what all the hype is about.

What are peptides?

Peptides are naturally occurring biological molecules, found in all living organisms. They play an essential role in all types of biological activity. Simply put, they’re a smaller version of protein. Peptides have different jobs within the cellular tissue, therefore we are able to pinpoint targeted uses for each type of peptide. 

There are 20 naturally-occurring amino acids which we can combine into an immense variety of different molecules – a lot like alphabet letters that then combine into various words. How many of these molecules create a particular chain determine whether it’s a peptide, a polypeptide, or a protein; all of which have their identifying properties. 

Peptides are molecules composed of 2-50 amino acids. Polypeptides are made of 50-100 amino acids and proteins are made of more than 100 amino acids. Peptides are signaling agents or hormones, and have very precise, specific functions. 

The way we apply those functions to supplement or amplify the body’s internal processes is what makes peptide therapy such an exciting new development throughout the course of optimizing health. 

Of the 7000 naturally occurring peptides, over 500 of them have therapeutic benefit. Scientist are identifying and developing more every month. Peptides have a wide range of functions, including:

  • Weight loss
  • Muscle building
  • Immune function
  • Wound healing
  • Cognitive function and memory
  • Gut health
  • Sexual performance and libido
  • Skin rejuvenation
  • Hair growth
  • Bone and joint health
  • Cancer
  • Longevity

Today we’ll focus on peptides that have the greatest effect on weight loss.

Growth Hormone-Releasing Hormones

Here is a bit more needed information about Growth Hormone (GH). The pituitary gland secretes GH. The hypothalamus makes GH Releasing Hormone (GHRH) that controls release. 

GH has a profound effect on fat breakdown, muscle building, blood sugar regulation, sleep, and immune function. It works directly, but also works through stimulating production of IGF-1. 

What makes it even more complicated is that GHRH has an effect on weight loss directly as well. It works peripherally just like GH to improve lipolysis (fat breakdown) and muscle development.

People previously took GH itself to achieve these benefits, but this actually suppresses GHRH release, thereby reducing its effect. So the new generation of peptides overcome that to have a much better effect.

As we age, the hypothalamus produces a hormone called somatostatin, which blocks the pituitary from releasing GH. As somatostatin levels rise, GH levels decrease. Anything we can do to reduce somatostatin levels will help GH levels.

GH-releasing peptides (GHRPs for short); also called ghrelin mimetics, which stimulate weight loss by directly improving your body’s process for breaking down fat (lipolysis). They also increase GH release which helps build muscle and burn fat through 2 mechanisms – direct stimulation of GH release as well as inhibition of somatostatin, which again blocks GH release.   

Are peptides similar to steroids?

Peptides have become the frontier of biohacking, with peptide supplements offered via injection, sprays, creams, and pills by medical professionals.  Although 100% legal, authorities have banned the use of peptides in competitive athletic sports due to the possibility of unfair advantage.  

To be clear, peptides are not steroids or testosterone.  

If you are interested in the relationship between testosterone and weight, read my article “How To Lose Weight For Healthy T Levels”.

Compared to steroids and testosterone, touted for their fast benefits (and potential side effects), peptides won’t turn you into the Hulk overnight. Peptides are more of a “slow burn” supplement to enhance your existing healthy lifestyle but not meant to replace time at the gym.  While peptides can help you burn fat while you eat, socialize and even sleep, you must combine them with other lifestyle factors over several months to see the best results. In other words, you still have to eat right and get proper exercise! 

Which Peptides for Weight Loss are the Best?

In the world of health and fitness, peptides have become a popular supplement for burning fat, building muscle, increasing energy and improving athletic ability.  The National Institute of Health is even recognizing peptides as a possible supplement therapy for obesity. 

Some peptide supplements (the ones considered performance-enhancing drugs, for example) are often more experimental than others.  Here are a few different peptide hormones that help with weight loss and enhance your performance. I’ve arranged them from most-studied to more experimental. 


CJC 1295 is a synthetic GHRH chain constructed with 30 amino acids. Through increased protein synthesis, science has shown this peptide chain to have benefits including increased fat loss, increased cellular repair, cellular regeneration, and increased muscle growth. Interestingly, researchers have also shown it to promote the type of deep, slow-wave sleep that facilitates muscle growth and memory retention.  

As with any GHRH-based peptide, careful calculation of dosage and timing cycles – along with cycle breaks – stave off the body’s natural tendency to adapt or “get used to” the therapy, thus reducing its overall effect. One dose of CJC-1295 raises GH levels for 6 days, but in a nice pulsatile fashion, which is what you want. 

Tesamorelin (GHRH peptide)

Tesamorelin is another GHRH (Growth Hormone-Releasing Hormone) peptide, that stimulates the pituitary gland to increase growth hormone secretion.  Tesamorelin is much more potent than CJC-1295 and can raise IGF-1 levels by as much as 150 points. 

This peptide is FDA-approved for lipodystrophy (when the body is unable to produce and maintain healthy fat tissue) and for men who have HIV who get lipodystrophy from some of the medicines that they take and that increases their abdominal fat.  Tesamorelin is the most highly researched peptide for fat loss, however it is not normally prescribed as a weight loss medication.


Ipamorelin is a growth hormone releasing peptide (GHRP) that works a little bit differently than the GHRH peptides.  Ipamorelin works by inhibiting somatostatin, thus taking the ‘breaks’ off GH production. Unlike other GHRPs, Ipamorelin will not increase your sense of hunger. Peptides such as GHRP-2 and GHRP-6 do increase hunger, so they need to be administered at night right before bed otherwise you’d be raiding the fridge and have the opposite effect if you’re trying to lose weight!  

A lot of people have moved to Ipamorelin because it increases fat metabolism with less side effects and because it can be combined with other peptides as well.  Also known for its anti-aging properties and improvements in energy, this can be used long term, up to a year. In the past, many peptides required in-office or self-administered injections.  You can now take Ipamorelin as a sublingual tablet taken under the tongue, before bed to coincide with your body’s natural growth hormone spike. 

The combination of CJC-1295 + Ipamorelin (“CJC/IPA”) delivers a more powerful response than either one alone because Ipamorelin is blocking somatostatin.

The key is nighttime dosing to boost overnight GH release, and avoid carbs or fat intake within 2 hours of dosing to ensure max effect.


Amlexanox is an anti-inflammatory compound that has the benefit of appetite suppression. Combined with Tetradecylthioacetic Acid (a fatty acid, TTA for short) can help regulate how much fat the body stores by influencing the genes that control metabolism. TTA can help people feel full more quickly while the fatty acid decreases overall hunger and burns fat. In addition to regulating fat metabolism, this fatty acid has antioxidant, anti-inflammatory and immunity-enhancing properties. 


First, a warning.  If you’re a competitive athlete, this compound is likely classed as a performance-enhancing drug, and you could get disqualified if you take it.

BPC stands for Body Protecting Compound, and it lives up to its name. 

It’s a newer peptide with less human research, but the studies using this on rats are pretty amazing.  Dubbed a ‘healing peptide’, the research has shown this peptide can heal Achilles tendons, torn knee ligaments and even repair leaky gut in our furry friends.  There were no discernible side effects in any of these studies, and anecdotal reports suggest that BPC-157 could help you heal like a Marvel mutant.  

Although its benefits are more focused on healing, when it comes to the life of an athlete, fast healing from injuries means shorter recovery times and less time for the weight to creep back on!

How Fast Can I See Results from Peptides?


Your results are dependent on many factors.  First, you truly only want to take peptides under the supervision of a medical practitioner as a part of a larger weight management plan. The number one thing to do is to really manage your diet and cook your own food so you can control what you’re eating. It’s been said that great abs are made in the kitchen, and the same is true of our overall health: it all starts with what’s on your fork. As exciting and effective as peptide therapy can be, it’s no magic wand.  

Balancing your other hormone levels is important, too.   When you optimize your testosterone and thyroid levels, you will experience a lot of synergistic effects. If you have all that dialed in, you’re eating well and you’re sleeping eight hours per night, you could see results within a few weeks, especially with Tesamorelin. Ipamorelin is a more gentle peptide that may take 3-6 months to begin to show its effect. 

Speak to your doctor about specific dosing and the right peptide for your goals.

We’ve discussed some of the benefits of peptides and some of them seem miraculous.  Outside of weight loss and muscle gain, studies show faster healing, more energy, improved sleep and even increased libido.  The growth hormone levels we produce decreases as we age (30% by age 50, and 50% by age 70), so peptides may even help with neurological function, possibly preventing Alzheimers.  

Used incorrectly though, peptides have the potential to cause side effects of varying degrees. 

Side Effects of Peptides

For healthy individuals, peptide supplements are unlikely to cause serious side effects because they are similar to the peptides present in everyday foods. That said, as with any treatment it’s always wise to exercise caution in tandem with your doctor. 

No studies have shown peptides to have any carcinogenic effects, however if you have any pre-existing medical conditions you could be at risk of adverse effects or interactions with other medications. 

How to Purchase Peptides

You may be wondering if you can just purchase peptides from a store or the internet.  

You can, but it’s really important to remember that there can be some questionable manufacturers that make it tough to sort out which are good and which are not. 

The purity of products is a critical aspect to peptide therapy – and that means that without knowing for sure, you could run the risk of sub-par or ineffective compounds. 

Quality control can be an issue for the every day buyer, therefore you could potentially purchase contaminated or dangerous compounds manufacturers have created without regulation.   

In the United States, only a few compound pharmacies actually create these peptide supplements due to state restrictions.  The FDA does not currently regulate supplements in the same way as with traditional medications, so it’s important that you apply awareness to that and exercise caution by running it past your doctor in advance. 

At the Gapin Institute we  prescribe peptide therapy and can create a well-balanced treatment plan for you. Remember, peptides are not a fix-all. They don’t replace good nutrition, sleep, stress management, fitness, etc.. In a sense, peptides are the icing on the cake.

Want the Ultimate Peptide Guide? Click HERE.


Peptides and peptide therapy are cutting-edge tools. You can use them to optimize your health, slow the aging process, and reduce inflammation. Learning new ways to target and use peptides, polypeptides and proteins helps you move away from disease and towards better health. 

If you’re interested in radically upgrading your health, you’ll want to keep a close eye on the power of peptides and consider adding these therapies to your regimen. After all, when it comes to living a better life for a longer span of time, we’re looking at brand new ways to do just that – and the sky’s the limit. 

The best place to start if you want a hormonal optimization or peptide program is by seeing a physician first.  

Gapin Institute is currently accepting new clients. If you are tired of being tired… or you have tried everything to lose that unwanted weight but nothing seems to be working, our Peptide therapy might be the piece to the puzzle that you are missing. Call us today to schedule your consultation. (941) 263-0212.

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With the Male 2.0 Method, I test your DNA, interpret the results, and create a customized strategy just for you. This plan is specific to YOUR individual genes and lifestyle.  It will improve every area of your life, from your health and professional productivity to your overall longevity and total wellbeing. 

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In Male 2.0, Dr. Tracy Gapin has turned everything we once thought we knew about men’s health and performance upside down. The old model of how to be “a man” is broken. A man who works himself to death. A man who tries to NOT get sick but isn’t really healthy either. A man who takes a pill for every ill but is never really cured. That was Male 1.0. Now, imagine being THE MAN ─ owning your performance in the bedroom, the weight room, and the boardroom. Living a fully optimized life. Becoming limitless. This is Male 2.0!

Tracy Gapin, MD, FACS  is a board-certified Urologist, Men’s Health Expert, Author, and Professional Speaker. Using state-of-the-art biometric monitoring, nutrition and lifestyle intervention, Dr. Gapin coaches Fortune 500 executives and evolutionary leaders of business, sports medicine, and high performance. He specializes in cutting-edge precision medicine with an emphasis on epigenetics, providing men with a personalized path to optimizing health & performance.

Men’s Health: Reverse Aging with NAD+

Aging is inevitable – but there’s a whole new frontier for optimizing our health through the latest genetic science and biohacking that can help you to slow down the aging process and maybe even reverse aging with NAD+.  NAD (short for nicotinamide adenine dinucleotide and also known as NAD+) has recently been getting a lot of attention as a cutting-edge tool to promote longevity.  

We’re taking it all the way down the cellular level here.

Properly functioning cellular metabolism is essential to health. The sum of every chemical reaction that happens inside the body, along with its molecular interactions, keeps the body in a state of balance. This is all made possible by coenzymes (“helper molecules”) and specific proteins acting as metabolic sensors that respond to conditions in the cells and body. NAD is a tiny coenzyme that plays an important role in this delicate dance. As you age, NAD+ decreases and with it goes cellular function that prevents disease and maintains vitality.

What is NAD+ and why is it important?

NAD+ is vital to cellular metabolism because it turns nutrients into cellular energy. It also activates a set of proteins called sirtuins that regulate cellular health. NAD+ creates the cellular energy that helps us to retain our youthful function, muscle strength, and physical stamina. When sirtuins were discovered they were quickly nicknamed “the longevity genes.” 

A fascinating aspect of NAD+ is its dual role in protecting against the factors that age us. This includes inflammation, DNA damage, and failing mitochondria (cell respiration). NAD+ promotes longevity by facilitating DNA repair and protecting mitochondria from early death. As a result, NAD lowers the risks for age-related brain diseases like Alzheimers or Parkinson’s and cardiovascular diseases (a leading cause of death for men). 

NAD is the building block for ALL of our systems such as the lymphatic, cardiovascular and nervous systems. It is responsible for our immune function, insulin regulation, and fatty acid oxidation. Without it, we would literally die!

Improving Health Through NAD+ Boosting Photo Credit: The Sinclair Lab

NAD+ and Aging

A NAD+ molecule isn’t consumed alone to create energy like fuel in a car. Instead, it works with proteins to carry out essential biological processes like cellular energy creation and maintaining healthy DNA. Sirtuins are some of the proteins that play a key role in these processes. They only function in the presence of NAD+ and this means that the body needs to constantly synthesize it to maintain cellular function. However, NAD levels markedly decline with age, creating an energy deficit that decreases the body’s ability to retain optimal health.

Sirtuins and NAD+ work together to help promote overall health.

For example, at age 50 a typical person may have only half the NAD+ they did in their younger years but by age 80, NAD+ levels drop to only 1-10 percent of the levels measured in youth. But recent studies have now shown that increasing NAD+ in the body can restore the body’s cellular function as though turning back time – actually slowing down the aging process. Essentially, men can reverse aging by restoring healthy levels of NAD+.

One study done on mice, showed an average 5 percent increase in their lifespan —even though supplementation did not begin until the mice were nearing the end of their natural lifespan of 24 months. That would be the equivalent of gaining nearly an additional four years of life to today’s average human expectancy of 79 years!

Another side effect of decreased NAD+ is that muscles begin to shrivel and grow weaker due to vascular aging (thinning and aging of blood vessels, reducing cellular health). Vascular aging is responsible for many disorders for men.  These may include cardiac and neurologic conditions, muscle loss, and impaired wound healing. The process can be slowed down with regular exercise, but gradually even exercise becomes less effective at holding off this weakening.  In further research findings, mice with NAD+ supplementation showed between 56 and 80 percent greater exercise capacity. This points to a reversal in vascular aging and an ability to maintain a youthful physical stamina. 

Furthermore, in two different animal models of neurodegenerative disease, increasing cellular NAD+ reduced the severity of the disorder, normalized neuromuscular function, and delayed memory loss.  Most studies started on mice, but more recently clinical studies have shown positive effects on humans. You can begin to see how crucial NAD+ is to a vital life – and how its depletion can rob you of this vitality as you age.

Reversing Aging with NAD+ Precursors

Most of the ways of increasing NAD+ do not include supplementing with NAD+ itself, but rather precursors to NAD+. There are 5 precursors to NAD+:

  • tryptophan
  • nicotinic acid (pyridine-3-carboxylic acid)
  • nicotinamide (nicotinic acid amide)
  • nicotinamide mononucleotide (NMN)
  • and nicotinamide riboside (NR).

We can get NAD+ in our bodies through diet.  This is done by consuming foods with NAD+ precursors in them – like fish, crimini mushrooms, and raw green vegetables. However, you can’t really eat enough of anything to significantly boost NAD+ levels. Taking a NAD+ precursor supplement can help mitigate the decline, improve cellular health, and even mitigate loss of telomeres.

NMN and NR are the most popular precursors found in the latest anti-aging supplements. However, NR (a unique member of the vitamin B3 family) has been found to be the most efficient. If you’re a wine fan, you may be familiar with another famous anti-aging compound: resveratrol. NR is 4x more bioavailable than resveratrol, quickly kicking the red-wine derivative to the curb.

It has a positive impact on Metabolism

NR doesn’t just have anti-aging effects, it has a positive impact on metabolism. Mice on high-fat diets with NR supplementation gained 60 percent less weight than they did on the same diet without NR. In addition, none of the mice on NR showed signs of diabetes. Instead, their energy levels improved. 

Nicotinamide adenine dinucleotide (NAD+) is an important target to extend lifespan and health span.

NAD+ Supplements

Renowned Harvard University geneticist David Sinclair is the pioneer in the supplementation business of NAD+ with Elysium Health. Although his anti-aging claims were first met with controversy because most studies had been done on mice (, the study arena has since been expanded to human trials done at the Mayo Clinic and the University of Washington.  Gaining support of researchers at the top of their field, these human studies point to the same benefits found in our small furry friends.

Dr. Sinclair has conducted a study to show the effectiveness of his supported supplement, Basis.  Previous studies had shown an increase in NAD+ over a 24 hour period. His study sought to determine whether cellular NAD+ levels could be sustained over the entire study period of eight weeks, and it did.

In a placebo-controlled trial of 120 healthy adults between the ages of 60-80, participants taking the recommended dose of Basis saw cellular NAD+ levels increase by an average of 40 percent over baseline after 30 days, sustained at this number to 60 days. Participants taking twice the recommended dose saw those levels increase by 90 percent after 30 days and 55 percent at 60 days. 

ChromaDex, another leading anti-aging company has taken the running lead in scientific support for their supplement TruNiagen. With over 100 preclinical trials, 5 published studies and 3 FDA safety reviews, the evidence surrounding NAD+ supplementation is overwhelming.

It was previously thought that NAD+ could not be given in oral form and only intravenously due to poor bioavailability and low intestinal absorption.  Newer research shows that oral forms of NAD+ supplementation do have positive effects.  NADOVIM is one of the first and earliest supplements on the market to contain actual NAD+ instead of NAD+ precursors in its formulation.

Researchers are still willing to explore the value of IV infusions of NAD+. This is a new area for further, detailed study and could potentially be an effective delivery method in some ways. Preliminary animal study evidence suggests that intravenously administered NAD+ may hold some interesting promise. Currently, there are no pre-clinical or clinical human studies, but this is a fast-moving advancement in what we are learning about the way NAD+ and NAD+ precursors are processed in tissues and across the blood-brain barrier. Stay tuned.

How to Increase NAD+ Levels Naturally

Before you go out and buy a Vitamin B3 or NR supplement, remember that reversing aging requires a systems-based, holistic approach. There is no such thing as a magic anti-aging pill. NAD+ treatment in addition to other lifestyle changes and structures is what ultimately adds more years to your life. It is important to take a high quality NAD+ supplement.  Also, here are additional recommendations to ensure you increase NAD+ and its anti-aging effects.


Fasting, or reducing your calorie intake for extended periods, is an excellent method for indirectly boosting the body’s NAD+ levels. It has been shown that, fasting is effective in increasing NAD+ levels.  However, a drastic reduction in calorie intake or fasting long term can have a counterproductive effect. Consider intermittent fasting or adopting a low carb-ketogenic diet to provide similar positive results.


Exercise is one of the easiest and most cost-effective methods for boosting NAD+ levels. In a nutshell, exercise forces our body muscles to produce more mitochondria. The increased production of mitochondria results in a natural boost in NAD+ levels in the body.


Research has shown that too much direct sunlight exposure can deplete the body of NAD+ because our body uses NAD+ to repair sun damaged cells from over exposure to UV rays. Reduce exposure to strong sunlight and wear sunscreen.

Healthy Diet

Eating a well balanced whole foods diet full of NAD+ precursor rich foods is a one-way ticket to reversing aging. Be sure to add more of the following into your diet: 

  • Fish – Varieties of fish like tuna, salmon and sardines are rich sources of NAD+ for the body. Be sure to source your fish from sustainable, wild-caught sources.
  • Green Vegetables – green vegetables contain all sorts of nutrients in them which are beneficial in a variety of ways including NAD+ precursors. Of these vegetables peas and asparagus have the highest amount.
  • Whole Grains – high in Vitamin B3 which also contains RN. Remember that vegetables and grains that are cooked or processed lose their nutrition as well as the vitamin source. Therefore, it is recommended that you should also eat raw vegetables and choose whole grains (rice, quinoa, etc) over processed foods such as chips and cereals.
Reduce Alcohol Intake

Alcohol interferes with healthy cellular processes and reduces the efficacy of NAD+. In fact, alcohol consumption has been shown to directly reduce levels of NAD+ (and testosterone) in the body. 

NAD+ precursors, exercise and caloric restriction can increase NAD+ levels.
NAD+ helps you get energy out of the food you eat, it protects cells from stress, it maintains healthy sleep cycles and it helps your cells repair damaged DNA.


If you are looking for supplements that reverse aging, the NAD+ research is very promising.  It should be considered as a part of a holistic health plan for every aging male.  Without exercise and a whole foods diet, NAD+ supplementation will have minimal effects. For men who are looking to take their performance and health to the next level, NAD+ can give you that extra edge.

Upgrade to Male™ 2.0 – Schedule a Consult! 

You’ll get access to a genetic-based report and analysis, along with a private consultation that will put you on track to your ultimate health. 

With the Male 2.0 Method, I test your DNA, interpret the results, and create a customized strategy just for you. This plan is specific to YOUR individual genes and lifestyle.  It will improve every area of your life, from your health and professional productivity to your overall longevity and total wellbeing. Male 2.0 gives you the actionable tools you need right now.  It reveals what you need to customize and design your future limitless self.

Click here to learn more about the lifelong benefits of a personalized genetics consultation and epigenetic coaching program. 

Want more tips to optimize your health?  Listen to the latest podcasts. Click HERE 

I look forward to working with you to take your health goals to the next level. 

Ready to take the steps to the next level?

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In Male 2.0, Dr. Tracy Gapin has turned everything we once thought we knew about men’s health and performance upside down. The old model of how to be “a man” is broken. A man who works himself to death. A man who tries to NOT get sick but isn’t really healthy either. A man who takes a pill for every ill but is never really cured. That was Male 1.0. Now, imagine being THE MAN ─ owning your performance in the bedroom, the weight room, and the boardroom. Living a fully optimized life. Becoming limitless. This is Male 2.0!

Tracy Gapin, MD, FACS  is a board-certified Urologist, Men’s Health Expert, Author, and Professional Speaker. Using state-of-the-art biometric monitoring, nutrition and lifestyle intervention, Dr. Gapin coaches Fortune 500 executives and evolutionary leaders of business, sports medicine, and high performance. He specializes in cutting-edge precision medicine with an emphasis on epigenetics, providing men with a personalized path to optimizing health & performance. 

What’s The Deal With Weight Gain And Low Testosterone?

If you’re struggling to see the results you want in your weight loss program, you may be dealing with a testosterone imbalance.

Have you been noticing that the number on the scale keeps increasing recently?

Is your midsection growing at a faster rate than the rest of your body?

Are you struggling to lose those pesky pounds?

Are you dieting and exercising but still not seeing the results you want?

Weight gain is a primary symptom of low testosterone.

If you have low testosterone, you’re more likely to have increased body fat.

And if you have increased body fat, you’re more likely to suffer from low testosterone.

This becomes a vicious cycle that can cause weight gain and prevent weight loss—no matter how hard you diet and exercise. This cycle can also impact other areas of your health, including stress, libido, fertility, energy, and risk for disease.

Let’s go through the basics of testosterone, how T is related to weight, and what you can do about breaking the cycle this week.

What is testosterone?

Testosterone is the “male sex hormone.” It’s the primary hormone that makes a male “manly.” Testosterone is necessary for the initial development of the testes and prostate as well as the ongoing production of sperm and semen.

Along with its sexual function, testosterone has other important purposes in the body as well. It plays a role in everything from libido to muscle development and brain health. Check out these 10 crazy and surprising effects of testosterone here.

A number of factors can cause low testosterone. This includes lifestyle, diet, and exercise. Age also plays a role, as testosterone levels naturally decline with age especially after age 50.

Because testosterone is so critical for sexual and overall health, low levels of testosterone can cause serious health concerns. Symptoms of low testosterone include:

  • Weight gain
  • Minimized libido (sex drive)
  • Low fertility
  • Loss of muscle mass
  • Weak bones
  • Lowered energy
  • Brain fog
  • Moodiness
  • Depression
  • Anxiety
  • Low self-esteem
  • Less body hair

In this post, we’re going to focus on the first symptom: weight gain.

Testosterone has a direct impact on your weight. Higher testosterone means less fat and more muscle. Lower testosterone means more fat and less muscle.

That means that testosterone not only impacts the way we look and feel, but it’s also an important aspect of overall health. Testosterone affects our weight, and weight is a proven indicator of future wellness. Being overweight is directly linked to a number of health problems, including high cholesterol, high blood sugar, type 2 diabetes, heart disease, stroke, and more.

So how does this work?

What is the relationship between weight gain and low testosterone?

A number of studies have proven that weight and testosterone are intimately linked.

Research has shown that low testosterone can cause weight gain. Thus, improving testosterone levels can help with weight loss. A 2013 study found that men taking testosterone supplements saw weight loss as a side effect. Over five years, they each lost an average of 36 pounds and 3.5 inches off the waist. Similar results were iterated in a 2016 study as well.The reverse is also true. Obesity or holding extra weight can actually reduce testosterone levels. One study found that 75% of men who qualified as obese also had hypogonadism, which is when the body produces lower amounts of testosterone.

Losing weight, then, actually shows an increase in testosterone levels—even without testosterone replacement therapy.  

So where does this link between weight gain and testosterone come from?

Below are the five primary ways testosterone impacts your weight.

  1. Testosterone plays a role in metabolism.

Testosterone plays a key role in your metabolism, which is the process that turns your carbs, fats, and proteins into energy and fuel.

This is likely because testosterone interacts with insulin and glucose. High levels of testosterone can “eat up” extra glucose. Otherwise, that glucose would be stored as fat cells in the body.

Higher levels of testosterone eat up more of your free-floating sugar to prevent weight gain.

In fact, one study found that men undergoing testosterone treatment showed a significant increase in basal metabolic rate, which is associated with a decrease in lean body mass.

In opposition, fat cells actually metabolize testosterone at a fast rate. The more fat you carry around, the faster you burn through your free testosterone.

So low testosterone causes weight gain… and then that extra fat actually minimizes your free testosterone even more.

  1. Testosterone builds muscle.

Muscle is an important part of weight loss. Your body has to burn up its fat stores in order to build the muscle that you’re creating. Plus, muscle actually burns more calories throughout the day than fatty tissue does.

Having more muscle on your body puts you in a positive cycle of maintained weight.

And testosterone is a key hormone in the process of muscle construction and protein synthesis.

Studies show that testosterone levels increase muscle mass by boosting the body’s ability to produce protein.

This means that higher testosterone can help increase muscle, which minimizes fat storage.

Testosterone also boosts HGH, the human growth hormone. This hormone is used to build or “grow” your muscle.

Studies have shown that men with low testosterone are more likely to have less muscle mass than men with normal T levels. Similarly, men with less muscle mass are at a greater risk for low testosterone levels.

If you want healthy and attractive muscles, you need testosterone.

  1. Testosterone regulates fat-storing estrogen.

Body fat contains an enzyme called aromatase. Aromatase converts testosterone to estradiol, which is a type of estrogen. Aromatase turns T into estrogen, which increases estrogen levels. This then signals the endocrine system to slow the production of testosterone.

Basically, fat tissue creates estrogen. Estrogen stops the production of testosterone.

Thus, reducing fat tissue helps minimize the extra estrogen caused by stored belly fat.

The reverse is also true. When testosterone is low, it increases the production of estrogen.

Estrogen then signals your body to store fat. That’s why women tend to have “softer” features and extra weight, especially around their midsection. The goal of this in females is to store fat so women have extra reserves in case they need to care for a fetus or baby.

Estrogen works the same way in a male. It tells your body to hold on to your fat “in case of emergency.” But in most cases, you’re not all that interested in holding on to extra fat tissue in case the apocalypse hits.

Body fat increases estrogen and lowers T.

And low T increases body fat storage.

Talk about a cycle of weight gain!

Thus, boosting testosterone levels can help minimize fat-storing estrogen. And losing weight can help reduce estradiol, allowing for more free-floating testosterone.

Find out more about the relationship between testosterone and estrogen, especially with regards to the estrogen in your food.

  1. Testosterone reduces cortisol levels.

Cortisol, the “stress hormone,” is proven to increase weight gain. You’ve likely found that during stressful periods of your life, you hold on to a little more poundage than you typically would.

This is because cortisol is released in response to stress and low blood sugar. The goal of cortisol is to suppress inflammation and raise blood sugar levels. This increase in blood sugar actually promotes fat storage, especially around the abdomen.

Cortisol also causes gluconeogenesis, which is when your body transforms its protein reserves into glucose. This basically transforms the protein within your muscles into fatty tissue. You’ll start losing muscle mass and gaining fat—which links back to #2 on this list.  

Testosterone and cortisol have an inverse relationship. High cortisol levels cause low levels of testosterone, and high testosterone levels cause low levels of cortisol. Low testosterone allows cortisol to run free, causing an increase in fat storage and gluconeogenesis.

Raising your testosterone levels reduces cortisol, which then minimizes the risk of extra fat storage.

You want high T and low cortisol for optimal health.

  1. Testosterone impacts energy and stamina.

Low energy is a symptom of low testosterone. Fatigue and sluggishness are common indicators of a hormonal imbalance.

Energy is an important part of losing weight. Men with low testosterone often find they don’t have the energy or motivation to workout. When they do exercise, their stamina is so low that the workout isn’t as productive or effective as it could be.

Plus, low energy tends to lead to a more stagnant lifestyle. This means fewer calories burned throughout the day—often accompanied by an increase in the consumption of calories.

This creates a discouraging effect for men looking to lose weight. They can’t bring themselves to the gym no matter how much they want to lose the weight.

Stagnation causes a quick uptick in poundage.

How can you lose weight and increase testosterone?

Because the relationship between weight and testosterone goes both ways, it can be challenging to answer the chicken or the egg question:

Am I gaining weight because of low testosterone or do I have low testosterone because I’m gaining weight?

But the answer to this question ultimately doesn’t matter.

You don’t want weight gain or low testosterone.

So how can you break the cycle?

You have to start by boosting your testosterone.

Whether your weight gain was the cause or effect of low testosterone, losing weight starts by increasing testosterone.

Click here to discover the 13 ways to increase testosterone naturally. You’ll also want to learn about the 7 testosterone boosting myths, so you can make sure your training regimen is on the right track.

Testosterone replacement therapy might be a solution for some men, but it can also have a number of associated risks. There are other healthier ways to try increasing testosterone while losing fat.

Below are a few of the best ways to increase testosterone while losing weight—kill two birds with one stone!

  1. Lift weights. Resistance exercise builds muscle faster than cardio. As discussed, lean muscle burns fat faster and triggers testosterone production.
  2. Use high-intensity interval training. Studies show that interval training boosts testosterone better than steady endurance exercise. Interval workouts also tap into fat reserves to eat away at the pounds you’re struggling to lose.
  3. Stress less. The more you stress, the more cortisol you have in your body. More cortisol means less testosterone. Minimizing your stress is crucial to maintaining a healthy hormone balance. I recommend yoga, because it helps reduce stress while growing muscle mass.
  4. Maintain a consistent routine. You need to be exercising regularly in order to have a long-term impact on your testosterone levels. The most effective routines include both cardio and weightlifting to boost muscle mass and burn fat simultaneously.
  5. Don’t shy away from fats. Healthy fats are actually an important part of testosterone production. Study after study shows that low-fat, high-protein diets kill testosterone, minimize muscle mass, and increase fat storage. A balance of fats, carbs, and protein is critical for hormonal health and balance.


Learn more about the Carnivore Diet and Fat Loss here

Learn other testosterone boosting methods here.


If you’re struggling to get rid of those pesky pounds, low testosterone may have something to do with it. The intimate relationship between testosterone and weight gain can create a vicious cycle that can be hard to break.

But if you boost your testosterone, you’ll increase muscle mass and strength, encourage weight loss, improve energy and stamina… and enrich your overall health and vitality!

I have the ultimate solution to breaking the cycle.

Because I’ve done it myself.

During a routine physical exam, I found out I was 25 pounds overweight. My cholesterol was 245. My doctor showed me my life expectancy chart based on my medical history and health… and it scared the crap out of me.

So I decided to make a change.

I decided to break the cycle.

And I’ve been helping men lose weight and boost testosterone ever since.

Now it’s your turn.

Ready to take the next steps?

Schedule a Call


In Male 2.0™, Dr. Tracy Gapin has turned everything we once thought we knew about men’s health and performance upside down. The old model of how to be “a man” is broken. A man who works himself to death.  Unfortunately, a man who tries to NOT get sick but isn’t really healthy either.  And a man who takes a pill for every ill but is never really cured. That was Male 1.0. Now, imagine being THE MAN ─ owning your performance in the bedroom, the weight room, and the boardroom. Living a fully optimized life. Becoming limitless. This is Male 2.0!

Tracy Gapin, MD, FACS  is a board-certified Urologist,  world renowned Men’s Health & Performance Expert, Author, and Professional Speaker. Using state-of-the-art biometric monitoring, nutrition and lifestyle intervention, Dr. Gapin coaches Fortune 500 executives and evolutionary leaders of business, sports medicine, and high performance. He specializes in cutting-edge precision medicine with an emphasis on epigenetics, providing men with a personalized path to optimizing health & performance.

Want more tips to optimize your health?  Listen to the latest podcasts. Click HERE